Role of Xenobiotic-Metabolizing Enzyme Gene Polymorphisms and Interactions with Environmental Factors in Susceptibility to Gastric Cancer in Kashmir Valley

2009 ◽  
Vol 40 (1-2) ◽  
pp. 26-32 ◽  
Author(s):  
Manzoor A. Malik ◽  
Rohit Upadhyay ◽  
Rama D. Mittal ◽  
Showket A. Zargar ◽  
Dinesh R. Modi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Environmental Factors ◽  
Gene Polymorphisms ◽  
Kashmir Valley ◽  
Enzyme Gene ◽  
Metabolizing Enzyme

scholarly journals The role of diet and other environmental factors in the causation of gastric cancer in Iran-A population based study

2009 ◽  
Vol 125 (8) ◽  
pp. 1953-1960 ◽  
Author(s):  
Farhad Pourfarzi ◽  
Anna Whelan ◽  
John Kaldor ◽  
Reza Malekzadeh
Keyword(s):  
Gastric Cancer ◽  
Environmental Factors ◽  
Population Based ◽  
Population Based Study

Role of NQO1 609C>T and NQO2-3423G>A Polymorphisms in Susceptibility to Gastric Cancer in Kashmir Valley

2011 ◽  
Vol 30 (5) ◽  
pp. 297-303 ◽  
Author(s):  
Manzoor Ahmad Malik ◽  
Showkat Ali Zargar ◽  
Balraj Mittal
Keyword(s):  
Gastric Cancer ◽  
Kashmir Valley

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

2000 ◽  
Vol 10 (8) ◽  
pp. 705-713 ◽  
Author(s):  
M. Pirmohamed ◽  
A. Alfirevic ◽  
J. Vilar ◽  
A. Stalford ◽  
E. G. L. Wilkins ◽  
...  
Keyword(s):  
Association Analysis ◽  
Gene Polymorphisms ◽  
Hiv Positive ◽  
Enzyme Gene ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals Los genes como marcadores de riesgo en cáncer gástrico: revisión de estudios en población colombiana

Respuestas ◽  
2013 ◽  
Vol 18 (2) ◽  
pp. 61-73
Author(s):  
Claudia Marcela Yáñez-Gutiérrez
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gene Polymorphisms ◽  
Genetic Factors ◽  
Human Gene ◽  
Risk Markers ◽  
Different Populations ◽  
H Pylori ◽  
Cáncer Gástrico

 El objetivo de esta revisión, fue identificar el rol de los genes como marcadores de riesgo en cáncer gástrico (CG) en población colombiana. Se revisaron publicaciones de investigaciones realizadas en los últimos diez años, utilizando las bases MEDLINE y LILACS y complementando  la pesquisa con la bibliografía relevante de los artículos. Se encontraron estudios en busca de asociación de CG con polimorfismos de varios genes humanos involucrados en la respuesta inmune, la desintoxicación y el supresor p53. En Colombia al igual que en otros países, las evidencias de asociación de polimorfismos genéticos con CG son aún controversiales, debido a la variación de los resultados que arrojan los estudios en las diferentes poblaciones. El genoma de las cepas de Helicobacter pylori que infectan población colombiana también ha sido investigado en búsqueda de polimorfismos de virulencia. El genotipo cagA/vacAs1m1 identificado como citotóxico en esta bacteria, mostró en la mayoría de las investigaciones, asociación con CG. La evidencia de asociación de CG con factores genéticos en población colombiana no es concluyente. Está lejos aún, la identificación de marcadores genéticos que permitan predecir el riesgo a desarrollar CG. A pesar de ello, algunos polimorfismos de genes humanos como los de IL-1 o los de algunas enzimas desintoxicantes, así como los genes cagA y vacA de Helicobacter pylori podrían ser candidatos a futuros marcadores de riesgo en esta neoplasia.Palabras clave: cáncer gástrico, riesgo, genotipo, Colombia. ABSTRACT  The objective of this review was to identify the role of genes as risk markers in gastric cancer (GC) in Colombian population studies. The study reviewed research publications in the last ten years, using the MEDLINE and LILACS, as well as various literature research of relevant articles. Searching studies found GC association with several human gene polymorphisms involved in the immune response, detoxification and suppressor p53. In Colombia, as in other countries, the evidence of the association of genetic polymorphisms with GC are still controversial because of the variation in results that studies in different populations. The genome of Helicobacter pylori strains that infect Colombian population has also been investigated in search of polymorphisms of virulence. cagA/ vacAs1m1 genotype identified as cytotoxic in this bacterium, demonstrated most of the research associated with GC. Evidence of association of GC with Colombian population genetic factors was inconclusive. It is yet to be determined the exact identification of genetic markers that can predict the risk of developing GC. However, some human gene polymorphisms as IL-1 or some detoxifying enzymes and the vacA and cagA of H. pylori could be candidates for future risk markers in these tumors.Keywords: gastric cancer, risk, genotype, Colombia

scholarly journals The Relationship between Toll-like Receptors andHelicobacter pylori-Related Gastropathies: Still a Controversial Topic

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Lorena Elena Meliț ◽  
Cristina Oana Mărginean ◽  
Cristian Dan Mărginean ◽  
Maria Oana Mărginean
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphisms ◽  
Experimental Studies ◽  
Large Family ◽  
Bacterial Invasion ◽  
Toll Like Receptors ◽  
Controversial Topic ◽  
H Pylori ◽  
Antigen Presenting

Innate immunity represents the first barrier against bacterial invasion. Toll-like receptors (TLRs) belong to the large family of pattern recognition receptors (PRRs), and their activation leads to the induction of inflammatory cytokines, chemokines, antigen-presenting molecules, and costimulatory molecules. Recent studies have focused on identifying the association between TLRs andHelicobacter pylori- (H. pylori-) related diseases. Therefore, this minireview focuses on assessing the role of these TLRs in the development ofH. pylori-related gastropathies. Both TLR2 and TLR were found to be involved inH. pyloriLPS recognition, with contradictory results most likely due to both the inability to obtain pure LPS in experimental studies and the heterogeneity of the bacterial LPS. In addition,TLR2was found to be the most extensively expressed gene among all the TLRs in gastric tumors. High levels of TLR4 were also associated with a higher risk of gastric cancer. TLR5 was initially associated with the recognition ofH. pyloriflagellin, but it seems that this bacterium has developed mechanisms to escape this recognition representing an important factor involved in the persistence of this infection and subsequent carcinogenesis. TLR9, the only TLR with both anti- and proinflammatory roles, was involved in the recognition ofH. pyloriDNA. The dichotomous role of TLR9, promoting or suppressing the infection, depends on the gastric environment. Recently, TLR7 and TLR8 were shown to recognize purifiedH. pyloriRNA, thereby inducing proinflammatory cytokines.TLR1andTLR10gene polymorphisms were associated with a higher risk for gastric cancer inH. pylori-infected individuals. Different gene polymorphisms of these TLRs were found to be associated with gastric cancer depending mostly on ethnicity. Further studies are required in order to develop preventive and therapeutic strategies againstH. pyloriinfections based on the functions of TLRs.

Frequencies of Xenobiotic-Metabolizing Enzyme Gene Polymorphisms CYP3A4, GSTM1 and GSTT1 in a Filipino Population

2014 ◽  
Vol 12 (1) ◽  
pp. 51-55
Author(s):  
Roldan M. De Guia ◽  
Ariana Anne P. Baluyot ◽  
Emmanuel Austin A. Banzon ◽  
Marice R. Bernal ◽  
Ralph Rayman B. Bio ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Enzyme Gene ◽  
Metabolizing Enzyme

scholarly journals Association Analysis of Drug Metabolizing Enzyme Gene Polymorphisms in AIDS Patients with Cutaneous Reactions to Sulfonamides

2005 ◽  
Vol 125 (5) ◽  
pp. 1080-1082 ◽  
Author(s):  
Pierre Wolkenstein ◽  
Marie-Anne Loriot ◽  
Antoine Flahault ◽  
Michel Cadilhac ◽  
Eric Caumes ◽  
...  
Keyword(s):  
Association Analysis ◽  
Gene Polymorphisms ◽  
Aids Patients ◽  
Enzyme Gene ◽  
Drug Metabolizing Enzyme ◽  
Cutaneous Reactions ◽  
Metabolizing Enzyme

scholarly journals Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis

2018 ◽  
Vol 69 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Aylin Elkama ◽  
Bensu Karahalil
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Environmental Factors ◽  
Gene Polymorphisms ◽  
Neurological Impairment ◽  
Vitamin D Metabolism ◽  
Vitamin D Levels ◽  
The Central Nervous System ◽  
Genetic And Environmental Factors

Abstract Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) resulting in neurological impairment and disability. There is evidence that adequate vitamin D levels may lower the risk of MS development. The aetiology of MS is complex and involves both genetic and environmental factors. In fact, not one but several genes are believed to lead to the disease. As for environmental factors, one of the most important risk factors is vitamin D deficiency, which, in turn, is closely related to gene polymorphisms that play a role in vitamin D metabolism and regulation. However, information about these gene polymorphisms is quite contradictory. The aim of this review is to discuss the association between some of the vitamin D-related gene variants and MS.

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