The relationship between Bmi-1 and the epithelial–mesenchymal transition in lung squamous cell carcinoma

2011 ◽  
Vol 29 (3) ◽  
pp. 1606-1613 ◽  
Author(s):  
Jun Huang ◽  
Yuan Qiu ◽  
Guoqin Chen ◽  
Liyan Huang ◽  
Jianxing He
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Lung Squamous Cell Carcinoma ◽  
Mesenchymal Transition ◽  
The Relationship

scholarly journals Klotho expression is correlated to molecules associated with epithelial‑mesenchymal transition in lung squamous cell carcinoma

2017 ◽  
Author(s):  
Takayuki Ibi ◽  
Jitsuo Usuda ◽  
Tatsuya Inoue ◽  
Akira Sato ◽  
Kyoshiro Takegahara
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Lung Squamous Cell Carcinoma ◽  
Mesenchymal Transition

scholarly journals P3.01-046 Klotho Regulates Epithelial-Mesenchymal Transition in Lung Squamous Cell Carcinoma

2017 ◽  
Vol 12 (1) ◽  
pp. S1147-S1148
Author(s):  
Takayuki Ibi ◽  
Jitsuo Usuda ◽  
Inoue Tatsuya ◽  
Kenta Hasumi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Lung Squamous Cell Carcinoma ◽  
Mesenchymal Transition

scholarly journals The Oncogenic Activity of miR-29b-1-5p Induces the Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma

2019 ◽  
Vol 8 (2) ◽  
pp. 273 ◽  
Author(s):  
Miyako Kurihara-Shimomura ◽  
Tomonori Sasahira ◽  
Hiroyuki Shimomura ◽  
Chie Nakashima ◽  
Tadaaki Kirita
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Histological Grade ◽  
Oral Epithelium ◽  
Mesenchymal Transition ◽  
The Relationship

Background: The relationship between miR-29b-1-5p and c-Met proto-oncogene in oral squamous cell carcinoma (OSCC) remains to be investigated. This study aimed to reveal the role of miR-29b-1-5p in the pathogenesis of OSCC using molecular and biological analyses. Methods: We investigated the expression of miR-29b-1-5p, c-Met, and markers of the epithelial-mesenchymal transition (EMT) in the tissues of 49 patients with OSCC and in human OSCC cells with different tumorigenicity. Further, we determined the effects of miR-29b-1-5p on the phenotypes of OSCC cell lines. Results: The expression levels of miR-29b-1-5p in most patients with OSCC were higher than those of the normal oral epithelium. In OSCC, upregulation of miR-29b-1-5p significantly correlated with histological grade, the EMT, and the immunohistochemical grade, indicated by c-Met expression. The prognosis was poor for patients with miR-29b-1-5p expression and coexpression of miR-29b-1-5p and c-Met. In OSCC cells exhibiting the EMT phenotype, knockdown of miR-29b-1-5p suppressed the EMT, which was recovered by enforced expression of c-Met. Further, the mRNA encoding cadherin 1 (CDH1) was a direct target of miR-29b-1-5p. Conclusions: Our results suggest that miR-29b-1-5p acts as an oncogenic miRNA that synergizes with c-Met to induce the EMT of OSCC cells.

CMTM4 regulates epithelial–mesenchymal transition and PD‐L1 expression in head and neck squamous cell carcinoma

2021 ◽  
Author(s):  
Hao Li ◽  
Yuan‐Tong Liu ◽  
Lei Chen ◽  
Jun‐Jie Zhou ◽  
De‐Run Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Epithelial Mesenchymal Transition ◽  
Neck Squamous Cell Carcinoma ◽  
Mesenchymal Transition
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