Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin Transporter Gene Expression: a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants

2015 ◽  
Vol 53 (8) ◽  
pp. 5510-5526 ◽  
Author(s):  
Sandra Iurescia ◽  
Davide Seripa ◽  
Monica Rinaldi
Keyword(s):  
Gene Expression ◽  
Serotonin Transporter ◽  
Genetic Architecture ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Promoter Polymorphisms ◽  
Allelic Variants ◽  
Functional Studies

scholarly journals Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaonan Lin ◽  
Yanmiao Cao ◽  
Linqin Ji ◽  
Wenxin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Peer Victimization ◽  
Inhibitory Control ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Chinese Han ◽  
Mediating Role ◽  
Adolescent Depressive Symptoms

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

Longitudinal Monitoring of the Serotonin Transporter Gene Expression to Assess Major Depressive Episode Evolution

2014 ◽  
Vol 70 (4) ◽  
pp. 220-227 ◽  
Author(s):  
Raoul Belzeaux ◽  
Anderson Loundou ◽  
Jean-Michel Azorin ◽  
Jean Naudin ◽  
El Chérif Ibrahim
Keyword(s):  
Gene Expression ◽  
Serotonin Transporter ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Major Depressive

Role of the Serotonin Transporter Gene in Temperament and Character

1999 ◽  
Vol 13 (4) ◽  
pp. 312-328 ◽  
Author(s):  
Dean H. Hamer ◽  
Benjamin D. Greenberg ◽  
Sue Z. Sabol ◽  
Dennis L. Murphy
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

scholarly journals Role of the serotonin transporter gene in the behavioral expression of autism

2001 ◽  
Vol 6 (4) ◽  
pp. 434-439 ◽  
Author(s):  
S Tordjman ◽  
L Gutknecht ◽  
M Carlier ◽  
E Spitz ◽  
C Antoine ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Behavioral Expression

A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population

2011 ◽  
Vol 26 (8) ◽  
pp. 471-478 ◽  
Author(s):  
V. Carli ◽  
L. Mandelli ◽  
L. Zaninotto ◽  
A. Roy ◽  
L. Recchia ◽  
...  
Keyword(s):  
High Risk ◽  
Serotonin Transporter ◽  
Well Being ◽  
Serotonin Transporter Gene ◽  
High Risk Population ◽  
Psychological Resilience ◽  
Transporter Gene ◽  
Specific Effects ◽  
Childhood Traumas

AbstractGenetic aspects may influence the effect of early adverse events on psychological well being in adulthood. In particular, a common polymorphism within the serotonin transporter gene (5-HTTLPR short/long) has been associated to the risk for stress-induced psychopathology. In the present study we investigated the role of childhood traumas and 5-HTTLPR on measures of psychological resilience and depression in a sample of individuals at a high risk for psychological distress (763 male prisoners). The 5-HTTLPR genotype did not influence resilience and depressive severity. However, a significant interaction was observed between 5-HTTLPR and childhood traumas on both resilience and depressive severity. In particular, among subjects exposed to severe childhood trauma only, the long-allele was associated to lower resilience scores and increased current depressive severity as compared to short/short homozygous. Sex specific effects, difference in type and duration of stressors and the specific composition of the sample may explain discrepancy with many studies reporting the short-allele as a vulnerability factor for reactivity to stress. We here speculated that in males the long-allele may confer lower resilience and therefore higher vulnerability for depressive symptoms in subjects exposed to early stress and currently living in stressful environments.

Functional Cortical Effects of Novel Allelic Variants of the Serotonin Transporter Gene-linked Polymorphic Region (5-HTTLPR) in Humans

2007 ◽  
Vol 40 (5) ◽  
pp. 191-195 ◽  
Author(s):  
J. Gallinat ◽  
D. Müller ◽  
J. Bierbrauer ◽  
H. Rommelspacher ◽  
G. Juckel ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Polymorphic Region ◽  
Allelic Variants
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