scholarly journals Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaonan Lin ◽  
Yanmiao Cao ◽  
Linqin Ji ◽  
Wenxin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Peer Victimization ◽  
Inhibitory Control ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Chinese Han ◽  
Mediating Role ◽  
Adolescent Depressive Symptoms

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

scholarly journals Mood changes after delivery: role of the serotonin transporter gene

2008 ◽  
Vol 193 (5) ◽  
pp. 383-388 ◽  
Author(s):  
J. Sanjuan ◽  
R. Martin-Santos ◽  
L. Garcia-Esteve ◽  
J. M. Carot ◽  
R. Guillamat ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Major Depression ◽  
Serotonin Transporter ◽  
Post Partum ◽  
Serotonin Transporter Gene ◽  
High Expression ◽  
Transporter Gene ◽  
Mood Changes ◽  
Post Partum Period

BackgroundPolymorphic variations in the serotonin transporter gene (5-HTT) moderate the depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction in brain tryptophan availability, thus polymorphic variations in5-HTTmay play a similar role in the post-partum period.AimsTo study the role of5-HTTpolymorphic variations in mood changes after delivery.MethodOne thousand, eight hundred and four depression-free Spanish women were studied post-partum. We evaluated depressive symptoms at 2–3 days, 8 weeks and 32 weeks post-partum. We used diagnostic interview to confirm major depression for all probable cases. Based on two polymorphisms of5-HTT(5-HTTLPR and STin2 VNTR), three genotype combinations were created to reflect different levels of5-HTTexpression.ResultsOne hundred and seventy-three women (12.7%) experienced major depression during the 32-week post-partum period. Depressive symptoms were associated with the high-expression5-HTTgenotypes in a dose–response fashion at 8 weeks post-partum, but not at 32 weeks.ConclusionsHigh-expression5-HTTgenotypes may render women more vulnerable to depressive symptoms after childbirth.

scholarly journals Maternal depressive symptoms and children's academic performance: sex differences in the mediating role of school experiences

2020 ◽  
pp. 1-10
Author(s):  
Marilyn N. Ahun ◽  
Lamprini Psychogiou ◽  
Frédéric Guay ◽  
Michel Boivin ◽  
Richard E. Tremblay ◽  
...  
Keyword(s):  
Sex Differences ◽  
Depressive Symptoms ◽  
Peer Victimization ◽  
School Engagement ◽  
School Experiences ◽  
Maternal Depressive Symptoms ◽  
Reading And Writing ◽  
Mediating Role ◽  
Writing Scores

Abstract Background Maternal depressive symptoms (MDSs) are negatively associated with children's academic performance, with stronger effects sometimes reported in boys. However, few studies have tested the mechanisms of this association. We examined the mediating role of school engagement and peer victimization in this association and tested for sex differences. Methods Participants were 1173 families from a population-based longitudinal Canadian study. MDSs were self-reported annually using the Centre for Epidemiologic Studies Depression Scale (child's age: 5 months to 5 years). Data on mediators (peer victimization, cognitive, behavioral, and emotional school engagement) were reported annually from ages 6–10 by multiple informants including children, parents, and teachers using items from validated scales. Mathematics, reading, and writing exam scores at age 12 were obtained from standardized exams administered by Québec's Ministry of Education and Teaching. Structural equation modeling was used to test mediation by school experiences in boys and girls. Results Exposure to MDSs was negatively associated with mathematics, reading, and writing scores in girls and with mathematics only in boys. Cognitive and behavioral engagement significantly mediated the association between MDSs and mathematics, reading, and writing scores in girls. There were no significant mediators for boys. Conclusions Prevention and intervention strategies aiming to improve school engagement might be beneficial for daughters of mothers experiencing depressive symptoms. Further research is needed to replicate these findings and to identify the mechanisms explaining this association in boys.

Role of the Serotonin Transporter Gene in Temperament and Character

1999 ◽  
Vol 13 (4) ◽  
pp. 312-328 ◽  
Author(s):  
Dean H. Hamer ◽  
Benjamin D. Greenberg ◽  
Sue Z. Sabol ◽  
Dennis L. Murphy
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene

scholarly journals Role of the serotonin transporter gene in the behavioral expression of autism

2001 ◽  
Vol 6 (4) ◽  
pp. 434-439 ◽  
Author(s):  
S Tordjman ◽  
L Gutknecht ◽  
M Carlier ◽  
E Spitz ◽  
C Antoine ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Behavioral Expression

A protective genetic variant for adverse environments? The role of childhood traumas and serotonin transporter gene on resilience and depressive severity in a high-risk population

2011 ◽  
Vol 26 (8) ◽  
pp. 471-478 ◽  
Author(s):  
V. Carli ◽  
L. Mandelli ◽  
L. Zaninotto ◽  
A. Roy ◽  
L. Recchia ◽  
...  
Keyword(s):  
High Risk ◽  
Serotonin Transporter ◽  
Well Being ◽  
Serotonin Transporter Gene ◽  
High Risk Population ◽  
Psychological Resilience ◽  
Transporter Gene ◽  
Specific Effects ◽  
Childhood Traumas

AbstractGenetic aspects may influence the effect of early adverse events on psychological well being in adulthood. In particular, a common polymorphism within the serotonin transporter gene (5-HTTLPR short/long) has been associated to the risk for stress-induced psychopathology. In the present study we investigated the role of childhood traumas and 5-HTTLPR on measures of psychological resilience and depression in a sample of individuals at a high risk for psychological distress (763 male prisoners). The 5-HTTLPR genotype did not influence resilience and depressive severity. However, a significant interaction was observed between 5-HTTLPR and childhood traumas on both resilience and depressive severity. In particular, among subjects exposed to severe childhood trauma only, the long-allele was associated to lower resilience scores and increased current depressive severity as compared to short/short homozygous. Sex specific effects, difference in type and duration of stressors and the specific composition of the sample may explain discrepancy with many studies reporting the short-allele as a vulnerability factor for reactivity to stress. We here speculated that in males the long-allele may confer lower resilience and therefore higher vulnerability for depressive symptoms in subjects exposed to early stress and currently living in stressful environments.

Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life

2015 ◽  
Vol 29 (5) ◽  
pp. 623-633 ◽  
Author(s):  
Davide Seripa ◽  
Andrea Pilotto ◽  
Giulia Paroni ◽  
Andrea Fontana ◽  
Grazia D’Onofrio ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Gene Locus ◽  
Late Life ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Major Depressive ◽  
Ssri Treatment
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