Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

2018 ◽  
Vol 55 (12) ◽  
pp. 8936-8952 ◽  
Author(s):  
Chia-Chia Lee ◽  
Ching-Pang Chang ◽  
Chun-Jung Lin ◽  
Hsing-Lin Lai ◽  
Yu-Han Kao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Neuronal Plasticity ◽  
Memory Impairment ◽  
Model Of Alzheimer’S Disease

scholarly journals Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Toshihiko Toda ◽  
Yoshihiro Noda ◽  
Genzo Ito ◽  
Masahiro Maeda ◽  
Takahiko Shimizu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Memory Impairment ◽  
Amyloid Β Protein ◽  
Model Of Alzheimer’S Disease ◽  
Amyloid Accumulation ◽  
Presenilin 2 ◽  
Tg2576 Mice

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice. Here, we demonstrate that the PS2 mutation induced the early deposition of amyloid β-protein (Aβ) at 2-3 months of age and progressive accumulation at 4-5 months of age in the brains of the mutant mice. The PS2 mutation also accelerated learning and memory impairment associated with Aβ accumulation at 4-5 months of age in Tg2576 mice. These results suggest that the PS2 mutation causes early cerebral amyloid accumulation and memory dysfunction. PS2Tg2576 mice are a suitable mouse model for studying amyloid-lowering therapies.

Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

2016 ◽  
Vol 54 (1) ◽  
pp. 450-460 ◽  
Author(s):  
Yura Choi ◽  
Ha Jin Jeong ◽  
Quan Feng Liu ◽  
Seung Tack Oh ◽  
Byung-Soo Koo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Model Of Alzheimer’S Disease

Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden

2013 ◽  
Vol 536 ◽  
pp. 74-79 ◽  
Author(s):  
Takuya Watanabe ◽  
Kotaro Takasaki ◽  
Norito Yamagata ◽  
Michihiro Fujiwara ◽  
Katsunori Iwasaki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Model Of Alzheimer’S Disease
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