(−)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse model of Alzheimer’s disease

Neuroreport ◽  
2017 ◽  
Vol 28 (10) ◽  
pp. 590-597 ◽  
Author(s):  
Yufang Guo ◽  
Yan Zhao ◽  
Ying Nan ◽  
Xiang Wang ◽  
Yulong Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Frontal Cortex ◽  
Memory Impairment ◽  
Synaptic Protein ◽  
Protein Levels ◽  
Model Of Alzheimer’S Disease

scholarly journals Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Toshihiko Toda ◽  
Yoshihiro Noda ◽  
Genzo Ito ◽  
Masahiro Maeda ◽  
Takahiko Shimizu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Memory Impairment ◽  
Amyloid Β Protein ◽  
Model Of Alzheimer’S Disease ◽  
Amyloid Accumulation ◽  
Presenilin 2 ◽  
Tg2576 Mice

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice. Here, we demonstrate that the PS2 mutation induced the early deposition of amyloid β-protein (Aβ) at 2-3 months of age and progressive accumulation at 4-5 months of age in the brains of the mutant mice. The PS2 mutation also accelerated learning and memory impairment associated with Aβ accumulation at 4-5 months of age in Tg2576 mice. These results suggest that the PS2 mutation causes early cerebral amyloid accumulation and memory dysfunction. PS2Tg2576 mice are a suitable mouse model for studying amyloid-lowering therapies.

Clozapine Improves Memory Impairment and Reduces Aβ Level in the Tg-APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

2016 ◽  
Vol 54 (1) ◽  
pp. 450-460 ◽  
Author(s):  
Yura Choi ◽  
Ha Jin Jeong ◽  
Quan Feng Liu ◽  
Seung Tack Oh ◽  
Byung-Soo Koo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Model Of Alzheimer’S Disease
Sign in / Sign up

Export Citation Format

Share Document