scholarly journals A common variant in chromosome 9p21 associated with coronary artery disease in Asian Indians

2009 ◽  
Vol 88 (1) ◽  
pp. 113-118 ◽  
Author(s):  
Arindam Maitra ◽  
Debabrata Dash ◽  
Shibu John ◽  
Prathima R. Sannappa ◽  
Anupam P. Das ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Asian Indians ◽  
Common Variant ◽  
Chromosome 9P21 ◽  
Artery Disease

A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease

2008 ◽  
Vol 36 (5) ◽  
pp. 889-893 ◽  
Author(s):  
Zhong Chen ◽  
Qi Qian ◽  
Genshan Ma ◽  
Jiahong Wang ◽  
Xiaoli Zhang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Onset ◽  
Common Variant ◽  
Chromosome 9P21 ◽  
Artery Disease

scholarly journals A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry

2011 ◽  
Vol 56 (3) ◽  
pp. 224-229 ◽  
Author(s):  
Brian G Kral ◽  
Rasika A Mathias ◽  
Bhoom Suktitipat ◽  
Ingo Ruczinski ◽  
Dhananjay Vaidya ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
African Ancestry ◽  
Common Variant ◽  
Chromosome 9P21 ◽  
Artery Disease ◽  
Cdkn2b Gene

scholarly journals Common Variant on Chromosome 9p21 Predicts Severity of Coronary Artery Disease

2011 ◽  
Vol 57 (13) ◽  
pp. 1497-1498 ◽  
Author(s):  
Kenneth Chan ◽  
Anna Motterle ◽  
Ross C. Laxton ◽  
Shu Ye
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Common Variant ◽  
Chromosome 9P21 ◽  
Artery Disease

scholarly journals Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden

2013 ◽  
Vol 61 (9) ◽  
pp. 957-970 ◽  
Author(s):  
Kenneth Chan ◽  
Riyaz S. Patel ◽  
Paul Newcombe ◽  
Christopher P. Nelson ◽  
Atif Qasim ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Burden ◽  
Chromosome 9P21 ◽  
Artery Disease ◽  
9P21 Locus

scholarly journals APOC3 genetic variation, serum triglycerides, and risk of coronary artery disease in Asian Indians, Europeans, and other ethnic groups

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Shiwali Goyal ◽  
Yosuke Tanigawa ◽  
Weihua Zhang ◽  
Jin-Fang Chai ◽  
Marcio Almeida ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Genetic Variation ◽  
Coronary Artery ◽  
American Indians ◽  
Asian Indians ◽  
Small Subset ◽  
Serum Triglycerides ◽  
Artery Disease ◽  
Cad Risk

Abstract Background Hypertriglyceridemia has emerged as a critical coronary artery disease (CAD) risk factor. Rare loss-of-function (LoF) variants in apolipoprotein C-III have been reported to reduce triglycerides (TG) and are cardioprotective in American Indians and Europeans. However, there is a lack of data in other Europeans and non-Europeans. Also, whether genetically increased plasma TG due to ApoC-III is causally associated with increased CAD risk is still unclear and inconsistent. The objectives of this study were to verify the cardioprotective role of earlier reported six LoF variants of APOC3 in South Asians and other multi-ethnic cohorts and to evaluate the causal association of TG raising common variants for increasing CAD risk. Methods We performed gene-centric and Mendelian randomization analyses and evaluated the role of genetic variation encompassing APOC3 for affecting circulating TG and the risk for developing CAD. Results One rare LoF variant (rs138326449) with a 37% reduction in TG was associated with lowered risk for CAD in Europeans (p = 0.007), but we could not confirm this association in Asian Indians (p = 0.641). Our data could not validate the cardioprotective role of other five LoF variants analysed. A common variant rs5128 in the APOC3 was strongly associated with elevated TG levels showing a p-value 2.8 × 10− 424. Measures of plasma ApoC-III in a small subset of Sikhs revealed a 37% increase in ApoC-III concentrations among homozygous mutant carriers than the wild-type carriers of rs5128. A genetically instrumented per 1SD increment of plasma TG level of 15 mg/dL would cause a mild increase (3%) in the risk for CAD (p = 0.042). Conclusions Our results highlight the challenges of inclusion of rare variant information in clinical risk assessment and the generalizability of implementation of ApoC-III inhibition for treating atherosclerotic disease. More studies would be needed to confirm whether genetically raised TG and ApoC-III concentrations would increase CAD risk.

scholarly journals The Chromosome 9p21 Variant Not Predicting Long-Term Cardiovascular Mortality in Chinese with Established Coronary Artery Disease: An Eleven-Year Follow-Up Study

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
I-Te Lee ◽  
Mark O. Goodarzi ◽  
Wen-Jane Lee ◽  
Jerome I. Rotter ◽  
Yii-der Ida Chen ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cardiovascular Mortality ◽  
Odds Ratio ◽  
Recessive Model ◽  
Dominant Model ◽  
Chromosome 9P21 ◽  
Artery Disease

Introduction. We examined whether the variant at chromosome 9p21, rs4977574, was associated with long-term cardiovascular mortality in Han Chinese patients with coronary artery disease (CAD).Methodology. Subjects who underwent coronary angiography for chest pain were consecutively enrolled. Fasting blood samples were collected for laboratory and genotype assessments. The information was correlated with data collected from the national death database.Results. There were 925 cases with CAD and 634 without CAD enrolled in the present study. The G allele conferred a significant increase in risk of CAD (odds ratio = 1.47,P=0.003in the dominant model; odds ratio = 1.36,P=0.018in the recessive model). During a median of 11 years (inter-quartile range between 5.2 and 12.5 years) of follow-up, neither the total nor the cardiovascular mortality was different among CAD subjects with different genotypes. Using Cox regression analysis, genotypes of rs4977574 still failed to predict cardiovascular mortality (hazard ratio = 1.25,P=0.138in the dominant model; hazard ratio = 1.05,P=0.729in the recessive model).Conclusions. The rs4977574 at chromosome 9p21 is associated with presence of CAD in Han Chinese. However, rs4977574 could not predict cardiovascular mortality in these CAD subjects during the eleven-year period of the study.

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