DNAH17 is essential for rat spermatogenesis and fertility

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MRS Rao

1985 ◽  
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Dieter Passia ◽  
Ke-Quan Chen ◽  
Walter E. Stumpf
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2009 ◽  
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A. V. Pahomova ◽  
A. V. Perova ◽  
...  

2016 ◽  
Vol 428 ◽  
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Anita Kumar ◽  
Sharvari Deshpande ◽  
Shobha Sonawane ◽  
N.H. Balasinor

1992 ◽  
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pp. R45-R49 ◽  
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P.T.k. Saunders ◽  
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Takako Gotohda

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Munekazu Naito ◽  
Jun Li ◽  
Hayato Terayama ◽  
Shuichi Hirai ◽  
...  

Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and are characterised by their ability to self-renew and to produce differentiated progeny that form spermatozoa. It has been demonstrated that rat spermatogenesis can occur in the seminiferous tubules of congenitally immunodeficient recipient mice after transplantation of rat SSCs. However, the testis is often viewed as an immune-privileged site in that autoimmunogenic antigens on germ cells do not normally elicit an immune response in situ. In the present study, we tried to transplant rat SSCs into immunocompetent mice after depletion of their own germ cells by means of busulfan. The results showed that some transplanted SSCs could undergo complete spermatogenesis in recipient mouse testes, the rat spermatozoa being detected in 7 of 28 recipient epididymides. A significant increase in mouse spermatozoa was also noted in all 28 epididymides of recipient mice regardless of whether rat spermatozoa were concurrently present or not. These results suggest that transplanted rat SSCs can be tolerated in the testes of immunocompetent mice and that the transplantation of rat SSCs stimulates endogenous spermatogenesis in the recipient mice.


1989 ◽  
Vol 28 (1) ◽  
pp. 81-98 ◽  
Author(s):  
Donald P. Evenson ◽  
Frank C. Janca ◽  
Lorna K. Jost ◽  
Rebecca K. Baer ◽  
David S. Karabinus

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