scholarly journals Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis

2019 ◽  
Vol 14 (1) ◽  
pp. 115-126 ◽  
Author(s):  
Changzhou Cai ◽  
Xin Song ◽  
Yishu Chen ◽  
Xueyang Chen ◽  
Chaohui Yu
Keyword(s):  
Systematic Review ◽  
Skeletal Muscle ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Skeletal Muscle Mass ◽  
Meta Analysis ◽  
Nonalcoholic Fatty Liver

scholarly journals Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths

2020 ◽  
Vol 8 ◽  
Author(s):  
Lucia Pacifico ◽  
Francesco Massimo Perla ◽  
Gianmarco Andreoli ◽  
Rosangela Grieco ◽  
Pasquale Pierimarchi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Skeletal Muscle Mass ◽  
Nonalcoholic Fatty Liver

scholarly journals Relationship Between Nonalcoholic Fatty Liver Disease and Low Skeletal Muscle Mass in Obese Youth

2021 ◽  
Vol 2 (2) ◽  
pp. 35-39
Author(s):  
David Silas ◽  
Jeremy Park ◽  
Joon Young Kim
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Skeletal Muscle Mass ◽  
Nonalcoholic Fatty Liver ◽  
Obese Youth

Previous studies in adults have found a correlation between nonalcoholic fatty liver disease (NAFLD) and sarcopenia. The present study evaluated the relationship between NFALD and skeletal muscle mass in overweight/obese youth. A total of 234 children and adolescents (age 8-16) was stratified into tertiles based on relative muscle mass (RMM). Total, regional lean body mass, and total fat mass were obtained by dual-energy X-ray absorptiometry. RMM was defined as the percent of muscle mass (kg) relative to the sum of muscle and fat mass (kg). NAFLD was diagnosed via ultrasononography and a subset of participants with NAFLD (n=40) underwent a liver biopsy. The lowest tertile had a significantly higher risk for obesity, dyslipidemia, insulin resistance, metabolic syndrome, NAFLD, and nonalcoholic steatohepatitis (NASH). The present study demonstrated an association between low muscle mass, NAFLD, and NASH in overweight/obese youth. Despite the strong scientific merits of the present study, a lack of race/ethnic description could be a major critique as different ethnic background (specifically in the minorities) may be disproportionately impacted by fat distribution and relative muscle mass. Even though there is a clear relationship between sarcopenia and NAFLD in the elderly, this association may not stem from the same origin in the pediatric population. Lastly, but not least, future studies should evaluate NAFLD in obese youth with varying degrees of metabolic disorders (i.e., metabolic syndrome).

scholarly journals The Association between Nonalcoholic Fatty Liver Disease and CT-Measured Skeletal Muscle Mass

2018 ◽  
Vol 7 (10) ◽  
pp. 310 ◽  
Author(s):  
Eun Choe ◽  
Hae Kang ◽  
Boram Park ◽  
Jong Yang ◽  
Joo Kim
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Skeletal Muscle Mass ◽  
Skeletal Muscle Index ◽  
Nonalcoholic Fatty Liver ◽  
Clinical Records

A relationship between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. The aim of this study was to evaluate the association between NAFLD and skeletal muscle mass measured by computed tomography (CT). The clinical records of individuals visiting our center for a routine health check-up who underwent abdominal ultrasonography and abdominal CT scanning were retrospectively reviewed. Sarcopenia was diagnosed according to body mass index (BMI)-adjusted skeletal muscle mass, which was measured by CT (CT-measured skeletal muscle index (SMICT)). Of the 1828 subjects (1121 males; mean age 54.9 ± 9.5 years), 487 (26.6%) were obese (BMI ≥ 25 kg/m2), and 454 (24.8%) had low muscle mass. Sarcopenic subjects had a significantly higher prevalence of NAFLD than nonsarcopenic subjects, regardless of obesity (35.9% vs. 26.8%, p = 0.004 in the nonobese group; 76.6% vs. 63.0%, p = 0.003 in the obese group). Sarcopenia was significantly associated with the risk of NAFLD (adjusted odds ratio (OR) (95% confidence interval (CI)), 1.51 (1.15–1.99)), and the risk of NAFLD increased with increasing severity of sarcopenia (adjusted OR (95% CI), 1.45 (1.09–1.92) vs. 2.51 (1.16–5.56), mild vs. severe sarcopenia, respectively). When the risk of NAFLD was analyzed according to the SMICT quartiles, the adjusted OR and 95% CI for the lowest muscle mass quartile compared to the highest were 1.78 (1.17–2.72) in males and 2.39 (1.13–5.37) in females. Low skeletal muscle mass, which was precisely measured by CT, is independently associated with NAFLD, suggesting that sarcopenia is a risk factor for NAFLD.

Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study

Hepatology ◽  
2018 ◽  
Vol 68 (5) ◽  
pp. 1755-1768 ◽  
Author(s):  
Gyuri Kim ◽  
Seung‐Eun Lee ◽  
You‐Bin Lee ◽  
Ji Eun Jun ◽  
Jiyeon Ahn ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Longitudinal Study ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Muscle Mass ◽  
Fatty Liver Disease ◽  
Skeletal Muscle Mass ◽  
Nonalcoholic Fatty Liver
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