scholarly journals Receptor type protein tyrosine phosphatases (RPTPs) – roles in signal transduction and human disease

2012 ◽  
Vol 6 (3) ◽  
pp. 125-138 ◽  
Author(s):  
Yiru Xu ◽  
Gary J. Fisher
Keyword(s):  
Signal Transduction ◽  
Human Disease ◽  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Type Protein

scholarly journals Receptor-type protein tyrosine phosphatases in cancer

2015 ◽  
Vol 34 (2) ◽  
pp. 61-69 ◽  
Author(s):  
Yu Du ◽  
Jennifer R. Grandis
Keyword(s):  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Type Protein

Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains

2016 ◽  
Vol 44 (5) ◽  
pp. 1295-1303 ◽  
Author(s):  
Maayan Barnea ◽  
Tsviya Olender ◽  
Mark T. Bedford ◽  
Ari Elson
Keyword(s):  
Molecular Mechanisms ◽  
Protein Tyrosine Phosphatases ◽  
Cellular Function ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Physiological Regulation ◽  
Protein Tyrosine ◽  
Physiological Conditions ◽  
Type Protein

Protein tyrosine phosphatases (PTPs) perform specific functions in vivo, despite being vastly outnumbered by their substrates. Because of this and due to the central roles PTPs play in regulating cellular function, PTP activity is regulated by a large variety of molecular mechanisms. We review evidence that indicates that the divergent C-terminal tail sequences (C-terminal domains, CTDs) of receptor-type PTPs (RPTPs) help regulate RPTP function by controlling intermolecular associations in a way that is itself subject to physiological regulation. We propose that the CTD of each RPTP defines an ‘interaction code’ that helps determine molecules it will interact with under various physiological conditions, thus helping to regulate and diversify PTP function.

scholarly journals Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity

2008 ◽  
Vol 1783 (2) ◽  
pp. 275-286 ◽  
Author(s):  
Yvet E. Noordman ◽  
Eveline D. Augustus ◽  
Jan T.G. Schepens ◽  
Renato G.S. Chirivi ◽  
Pablo Ríos ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Type Protein

Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals

2010 ◽  
Vol 22 (12) ◽  
pp. 1811-1817 ◽  
Author(s):  
Takashi Matozaki ◽  
Yoji Murata ◽  
Munemasa Mori ◽  
Takenori Kotani ◽  
Hideki Okazawa ◽  
...  
Keyword(s):  
Biological Function ◽  
Protein Tyrosine Phosphatases ◽  
Receptor Type ◽  
Tyrosine Phosphatases ◽  
Protein Tyrosine ◽  
Type Protein
Sign in / Sign up

Export Citation Format

Share Document