Usefulness of Pulsed Wave Tissue Doppler Imaging in Assessment of Left Ventricular Functions in Children with Beta-Thalassemia Major

2013 ◽  
Vol 80 (9) ◽  
pp. 721-725 ◽  
Author(s):  
Ahmed Mahmoud Abdelmoktader ◽  
Hany Younan Azer
Keyword(s):  
Tissue Doppler Imaging ◽  
Thalassemia Major ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Ventricular Functions

scholarly journals THE DIAGNOSTIC VALUE OF PULSED WAVE TISSUE DOPPLER IMAGING IN ASYMPTOMATIC BETA- THALASSEMIA MAJOR CHILDREN AND YOUNG ADULTS ; RELATION TO CHEMICAL BIOMARKERS OF LEFT VENTRICULAR FUNCTION AND IRON OVERLOAD .

2015 ◽  
Vol 7 ◽  
pp. e2015051 ◽  
Author(s):  
Seham Ragab
Keyword(s):  
Iron Overload ◽  
Serum Ferritin ◽  
Tissue Doppler Imaging ◽  
Mitral Annulus ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Beta Thalassemia ◽  
Ejection Time ◽  
Diastolic Velocity

Background: Cardiac iron toxicity is the leading cause of death among  β-halassaemia major (TM)  patients.  Once  heart failure becomes overt , it will be  difficult to reverse . Objectives: To investigate non overt cardiac dysfunctions  in TM patients using  pulsed wave Tissue Doppler  Imaging (TD I) and its relation to the iron overload and brain natruritic peptide (BNP). Methods: Thorough  clinical , conventional echo and  pulsed  wave TDI  parameters were compared between  asymtomatic 25 β-TM  patients  and 20 age and gender matched individuals. Serum ferritin and plasma BNP  levels were assayed by  ELISA .  Results: TM patients had significant higher mitral inflow early diastolic (E) wave and  non significant other conventional echo  parameters. Pulsed wave TDI revealed systolic and diastolic dysfunctions in the form of significant higher  isovolumetric contraction time (ICT) , ejection time ( E T) and  isovolumetric relaxation time (IRT) with significantly lower  mitral annulus  early diastolic velocity E` (12.07 ±2.06 vs 15.04±2.65 ,P= 0.003)  in patients compared to  controls. Plasma BNP was higher in patients compared to the controls.  Plasma BNP and serum ferritin had significant correlation with each other and with pulsed wave conventional and TDI indices of systolic and diastolic functions.  Patients with E/E` ≥ 8 had  significant higher  serum ferritin  and plasma BNP levels compared to those with E/E` ratio < 8 without difference in Hb levels .Conclusion:  Pulsed wave TDI  is an  important diagnostic tool for latent cardiac dysfunction in iron loaded TM patients and is related to iron overload and BNP .    

Assessment of Left Ventricular Functions in Patients With Isolated Coronary Artery Ectasia by Conventional and Tissue Doppler Imaging

Angiology ◽  
2008 ◽  
Vol 59 (3) ◽  
pp. 306-311 ◽  
Author(s):  
Mustafa Saglam ◽  
Irfan Barutcu ◽  
Osman Karakaya ◽  
Ali Metin Esen ◽  
Taylan Akgun ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Tissue Doppler Imaging ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Coronary Artery Ectasia ◽  
Ventricular Functions

scholarly journals TO STUDY RIGHT VENTRICLE (RV) AND LEFT VENTRICLE ( LV) DYSFUNCTION IN TRANSFUSION DEPENDENT BETA THALASSEMIA CHILDREN AT TERTIARY CARE HOSPITAL IN NORTH WEST RAJASTHAN

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Sandeep Kulhari ◽  
Dinesh Choudhary ◽  
Himanshu Gupta ◽  
Rajneesh Patel ◽  
Jaipal Bugalia ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Tissue Doppler Imaging ◽  
Thalassemia Major ◽  
Tissue Doppler ◽  
Doppler Imaging ◽  
Beta Thalassemia ◽  
Blood Transfusions ◽  
Care Hospital ◽  
Lv Dysfunction

Background- Regular blood transfusions used for long term survival in  ß-thalassemia major patients cause a secondary state of tissue iron overload. Myocardial iron deposition can result in cardiomyopathy, and heart failure remains the leading cause of death. This study was planned to see the Right Ventricle (RV) and Left Ventricle(LV)dysfunction in beta thalassemia  transfused patients. Method- Patients of ß thalassemia major above 2 years of age received regular blood transfusions at least for 1 year duration, attending OPD in the Department of Pediatrics, S P Medical College, Bikaner were included.Echo  was  correlated with serum ferritin Level(SFL). Results- Tissue Doppler imaging(TDI) parameters of 50 patients at mitral annulus e.g. Em septal, Em Lateral, Am septal, Am lateral, Sm Septal and Sm Lateral were abnormal(<2SD and >2SD)in 70% & 0%, 50% & 4%, 10% & 46%, 34% & 24%, 40% & 22% and 60% & 10% patients respectively.TDI parameters at tricuspid valvee.g. Et, At and St were abnormal(<2SD)in 98%, 96% and 98% patients respectively. The differences in mean values of Et, At and St, when compared in the SFL groups <2500,2500-5000 and>5000, was non significant(p>0.05). Conclusion- TDI is superior to conventional echocardiography in giving an early evidence of diastolic myocardial dysfunction in asymtopmatic and normal LV function patients.TDI can be applied as an integrated part of assessment of children & adolescents with ß-thalassemia. Septal Sm, Em & lateral Em, Sm, Am and RV Et, At, St were reduced early in majority of patients. Our study showed early involvement of septum and RV in thalassemic patients. Key Words: ß-thalassemia major ;Right Ventricle (RV) and Left Ventricle ( LV) dysfunction; Echocardiogram ;Tissue Doppler Imaging

Left ventricular functions in patients with beta-thalassemia major: a speckle tracking imaging study

2020 ◽  
Vol 33 (1) ◽  
pp. 138
Author(s):  
AmirI Lashin ◽  
AhmedA Khattab ◽  
MohamedF Elnoamany ◽  
NaglaaF Ahmed ◽  
DoaaM Elian
Keyword(s):  
Speckle Tracking ◽  
Imaging Study ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
Beta Thalassemia ◽  
Speckle Tracking Imaging ◽  
Beta Thalassemia Major ◽  
Ventricular Functions
Sign in / Sign up

Export Citation Format

Share Document