TO STUDY RIGHT VENTRICLE (RV) AND LEFT VENTRICLE ( LV) DYSFUNCTION IN TRANSFUSION DEPENDENT BETA THALASSEMIA CHILDREN AT TERTIARY CARE HOSPITAL IN NORTH WEST RAJASTHAN

Background- Regular blood transfusions used for long term survival in ß-thalassemia major patients cause a secondary state of tissue iron overload. Myocardial iron deposition can result in cardiomyopathy, and heart failure remains the leading cause of death. This study was planned to see the Right Ventricle (RV) and Left Ventricle(LV)dysfunction in beta thalassemia transfused patients. Method- Patients of ß thalassemia major above 2 years of age received regular blood transfusions at least for 1 year duration, attending OPD in the Department of Pediatrics, S P Medical College, Bikaner were included.Echo was correlated with serum ferritin Level(SFL). Results- Tissue Doppler imaging(TDI) parameters of 50 patients at mitral annulus e.g. Em septal, Em Lateral, Am septal, Am lateral, Sm Septal and Sm Lateral were abnormal(<2SD and >2SD)in 70% & 0%, 50% & 4%, 10% & 46%, 34% & 24%, 40% & 22% and 60% & 10% patients respectively.TDI parameters at tricuspid valvee.g. Et, At and St were abnormal(<2SD)in 98%, 96% and 98% patients respectively. The differences in mean values of Et, At and St, when compared in the SFL groups <2500,2500-5000 and>5000, was non significant(p>0.05). Conclusion- TDI is superior to conventional echocardiography in giving an early evidence of diastolic myocardial dysfunction in asymtopmatic and normal LV function patients.TDI can be applied as an integrated part of assessment of children & adolescents with ß-thalassemia. Septal Sm, Em & lateral Em, Sm, Am and RV Et, At, St were reduced early in majority of patients. Our study showed early involvement of septum and RV in thalassemic patients. Key Words: ß-thalassemia major ;Right Ventricle (RV) and Left Ventricle ( LV) dysfunction; Echocardiogram ;Tissue Doppler Imaging

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The efficacy of tissue Doppler imaging in predicting myocardial iron load in patients with beta-thalassemia major: correlation with T2* cardiovascular magnetic resonance

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-010-9591-6 ◽

2010 ◽

Vol 26 (4) ◽

pp. 413-421 ◽

Cited By ~ 19

Author(s):

Ebru Aypar ◽

Dursun Alehan ◽

Tuncay Hazırolan ◽

Fatma Gümrük

Keyword(s):

Cardiovascular Magnetic Resonance ◽

Magnetic Resonance ◽

Tissue Doppler Imaging ◽

Thalassemia Major ◽

Tissue Doppler ◽

Doppler Imaging ◽

Beta Thalassemia ◽

Myocardial Iron ◽

Beta Thalassemia Major ◽

Iron Load

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Diastolic dysfunction in patients with brucellosis despite the absence of infective endocarditis

Cardiology in the Young ◽

10.1017/s1047951120002930 ◽

2020 ◽

Vol 30 (12) ◽

pp. 1840-1843

Author(s):

İbrahim Ece ◽

Serdar Epçaçan ◽

Gülsüm İclal Bayhan ◽

Mehmet Türe

Keyword(s):

Infective Endocarditis ◽

Left Ventricle ◽

Right Ventricle ◽

Diastolic Dysfunction ◽

Tissue Doppler Imaging ◽

Cardiac Involvement ◽

Peak Velocity ◽

Tissue Doppler ◽

Doppler Imaging ◽

Healthy Children

AbstractBackground:Brucellosis is an important systemic infectious disease, especially in developing countries. Every organ and system of the human body can be affected; however, cardiovascular complications of brucellosis are rare.Aim:To assess cardiac functions in patients with acute brucellosis without overt cardiac involvement and to answer the following question: Is there any cardiac dysfunction despite the absence of endocarditis in these patients?Methods:This cross-sectional study included 67 children with brucellosis and 40 healthy children. We performed a detailed echocardiographic examination in individuals at the beginning of the treatment. Patients with infective endocarditis were excluded from the study.Results:Echocardiography revealed no difference of ejection fraction, mitral and tricuspid annular plane systolic excursion, pulsed-wave Doppler-derived early diastolic peak velocity (E)/late diastolic peak velocity (A) ratios in mitral and tricuspid valves between the two groups. The deceleration time of early mitral inflow was longer in patients with brucellosis. Early diastolic peak velocity of the mitral and tricuspid annuluses obtained by tissue Doppler imaging (Ea) was significantly lower in children with brucellosis. The peak velocity obtained by tissue Doppler imaging during late diastole (Aa), Ea and Ea/Aa ratios in the interventricular septum, left ventricle posterior wall and right ventricle free wall was lower in patients with brucellosis than in the control group. The E/Ea ratio, isovolumic relaxation time, right ventricle and left ventricle myocardial performance indices were higher in patients with brucellosis.Conclusion:Patients with acute brucellosis may have diastolic dysfunction without overt cardiac involvement and infective endocarditis.

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