Japanese guideline for the oncology FDG-PET/CT data acquisition protocol: synopsis of Version 1.0

The purpose of this paper was to study the value of 18-FDG PET/CT and reassess the value of CT for the characterization of indeterminate adrenal masses. 66 patients with 67 indeterminate adrenal masses were included in our study. CT/MRI images and 18F-FDG PET/CT data were evaluated blindly for tumor morphology, enhancement features, apparent diffusion coefficient values, maximum standardized uptake values, and adrenal-to-liver maxSUV ratio. The study population comprised pathologically confirmed 16 adenomas, 19 metastases, and 32 adrenocortical carcinomas. Macroscopic fat was observed in 62.5% of the atypical adenomas at CT but not in malignant masses. On 18F-FDG PET/CT, SUVmax and adrenal-to-liver maxSUV ratio were significantly lower in adenomas than in malignant tumors. An SUVmax value of less than 3.7 or an adrenal-to-liver maxSUV ratio of less than 1.29 is highly predictive of benignity.

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Use of 68Ga-PSMA-11 and 18F-FDG PET-CT Dual-Tracer to Differentiate Between Lymph Node Metastases and Ganglia

Frontiers in Oncology ◽

10.3389/fonc.2021.646110 ◽

2021 ◽

Vol 11 ◽

Author(s):

Yiping Shi ◽

Lian Xu ◽

Yinjie Zhu ◽

Yining Wang ◽

Ruohua Chen ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastases ◽

Fdg Pet ◽

Standardized Uptake Value ◽

Fdg Uptake ◽

Positron Emission ◽

Pet Ct ◽

Node Metastases ◽

Ct Data ◽

Fdg Pet Ct

PurposeDifferentiating lymph node metastases (LNM) from peripheral ganglia by physiological prostate-specific membrane antigen (PSMA) uptake is challenging. Two tracers (68Ga-PSMA-11 and 18F-fluorodeoxyglucose [FDG]) metabolic uptake patterns were evaluated by positron emission tomography-computed tomography (PET-CT), searching for differences that could tell ganglia from LNM.MethodsDual 68Ga-PSMA-11 and 18F-FDG PET-CT data of 138 prostate cancer patients acquired from June 2018 to December 2019 were retrospectively evaluated. Ganglia and LNM with PSMA-11 uptake above local background were analyzed by the location and PSMA-11-PET and FDG-PET maximum standardized uptake value (SUVmax).ResultsPSMA-11-positive ganglia (n = 381) and LNM (n = 83) were identified in 138 and 58 patients, respectively. The LNM SUVmax of PSMA-11-PET (16.4 ± 14.8 vs 2.3 ± 0.7, P < 0.001) and FDG-PET (3.3 ± 3.2 vs 1.5 ± 0.5, P < 0.001) were higher than in ganglia. The probabilities of being an LNM in the low-potential (PSMA-11-PET SUVmax of <4.1 and FDG-PET SUVmax of <2.05), moderate-potential (PSMA-11-PET SUVmax of >4.1 and FDG-PET SUVmax of <2.05, or PSMA-11-PET SUVmax of <4.1 and FDG-PET SUVmax of >2.05), and high-potential (PSMA-11-PET SUVmax of >4.1 and FDG-PET SUVmax of >2.05) groups were 0.9% (3/334), 44.6% (37/83), and 91.5% (43/47), respectively (P < 0.001). The cervical and coeliac ganglia had higher PSMA-11 and FDG uptake than the sacral ganglia (P < 0.001 for all). LNM PSMA-11 and FDG uptake was similar in these three locations.ConclusionThe FDG-PET and PSMA-11-PET SUVmax, especially when combined, could well differentiate LNM from ganglia. The tracers uptake differed between cervical/coeliac and sacral ganglia, so the lesion location should be considered during image assessment.

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18F-FDG-PET/CT for Evaluation of treatment response in high grade lymphoma

Nepalese Journal of Cancer ◽

10.3126/njc.v1i1.25631 ◽

2017 ◽

Vol 1 (1) ◽

pp. 42-52

Author(s):

Yadav Ajay Kumar ◽

Kumar Rakesh ◽

Malhotra Arun ◽

Sharma Atul

Keyword(s):

Treatment Response ◽

Fdg Pet ◽

High Grade ◽

Predictive Values ◽

Pet Ct ◽

18F Fdg ◽

Ct Data ◽

Sensitivity Specificity ◽

Fdg Pet Ct ◽

Post Therapy

18F-FDG PET is highly sensitive and specific for evaluation of the treatment response of high-grade lymphomas. The molecular information provided by 18F-FDG-PET identifies the functional content of anatomic finding and helps to categorize their nature as malignant or benign. On the other hand, the CT data obtained in the same setting provides anatomical localization of the 18F-FDG-PET data while also improving the FDG-PET image quality as it is utilized for attenuation correction. Previously, most of the studies were done on this topic by using 18F-FDG-PET alone. Present study was planning to assess the role of 18F-FDG-PET/CT in evaluation of treatment response in patient of HD and NHL. Results showed that 43 patients out of 52 showed no pathologic FDG uptakes, whereas 9 showed persistent uptakes. Among the 43 patients who had negative PET scans, only three relapsed, whereas among the 9 patients who had persistent abnormal 18F-FDG uptakes on post therapy PET/CT scans, two recovered. The sensitivity, specificity, positive and negative predictive values and accuracy of post therapy PET/CT scan was 70%, 95%, 78%, 93%, and 90% respectively.

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Prone 18F-FDG PET/CT changes diagnostic and surgical intervention in a breast cancer patient: some considerations about PET/CT imaging acquisition protocol

Clinical Imaging ◽

10.1016/j.clinimag.2014.11.005 ◽

2015 ◽

Vol 39 (3) ◽

pp. 506-509 ◽

Cited By ~ 3

Author(s):

Carla Canevari ◽

Francesca Gallivanone ◽

Veronica Zuber ◽

Alberto Marassi ◽

Claudio Losio ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patient ◽

Breast Cancer Patient ◽

Fdg Pet ◽

Surgical Intervention ◽

Ct Imaging ◽

Acquisition Protocol ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Examination of Bed Overlaps in 18F-FDG PET/CT 3D Data Acquisition

Japanese Journal of Radiological Technology ◽

10.6009/jjrt.62.855 ◽

2006 ◽

Vol 62 (6) ◽

pp. 855-862

Author(s):

Hiroki Shishido ◽

Nobuaki Otsuka ◽

Takahiro Tominaga

Keyword(s):

Data Acquisition ◽

Fdg Pet ◽

3D Data ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Evaluation of Malignancy Risk in 18F-FDG PET/CT Thyroid Incidentalomas

Diagnostics ◽

10.3390/diagnostics9030092 ◽

2019 ◽

Vol 9 (3) ◽

pp. 92 ◽

Cited By ~ 1

Author(s):

Larg ◽

Apostu ◽

Peștean ◽

Gabora ◽

Bădulescu ◽

...

Keyword(s):

Fdg Pet ◽

Standard Uptake Value ◽

Needle Aspiration ◽

Malignancy Risk ◽

Positron Emission ◽

Pet Ct ◽

Thyroid Uptake ◽

Risk Of Malignancy ◽

Ct Data ◽

Fdg Pet Ct

Thyroid incidentalomas detected by 18 fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) are a real challenge for nuclear medicine physicians and clinicians. This study aimed to evaluate the risk of malignancy for patients with focal thyroid incidentalomas (TIs) diagnosed through FDG PET/CT. Data from 6900 patients, with a known primary tumor, who had an FDG PET/CT investigation performed were analyzed for the presence of incidental thyroid uptake. The focal TIs were reported, and the patients were referred for further investigation to the endocrinology department. There were 126 patients (1.82%) who presented with focal thyroid uptake, and for 87 of them, investigations were completed with ultrasonography (US), and for 29 with a fine needle aspiration biopsy (FNAB) procedure. Malignancy was detected in 7.93% (10/126) of cases. An arbitrary cutoff value of four was established for the standard uptake value lean body mass (SUVlbm Max) to differentiate the malignant nodules from the benign ones, and this value was significantly associated with malignancy (p = 0.0168). TIs are not so frequent, but they have a potential malignancy risk, and a proper evaluation is required. Even though SUVlbm Max is a predictive factor for malignancy, the FNAB remains the main diagnostic method for the therapeutic management of these patients.

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Can dynamic imaging, using 18F-FDG PET/CT and CT perfusion differentiate between benign and malignant pulmonary nodules?

Radiology and Oncology ◽

10.2478/raon-2021-0024 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Aleksander Marin ◽

John T. Murchison ◽

Kristopher M. Skwarski ◽

Adriana A.S. Tavares ◽

Alison Fletcher ◽

...

Keyword(s):

Blood Volume ◽

Fdg Pet ◽

Pulmonary Nodules ◽

Perfusion Ct ◽

Dynamic Imaging ◽

Lung Nodules ◽

Maximum Slope ◽

Pet Ct ◽

Ct Data ◽

Fdg Pet Ct

Abstract Background The aim of the study was to derive and compare metabolic parameters relating to benign and malignant pulmonary nodules using dynamic 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET/CT, and nodule perfusion parameters derived through perfusion computed tomography (CT). Patients and methods Twenty patients with 21 pulmonary nodules incidentally detected on CT underwent a dynamic 18F-FDG PET/CT and a perfusion CT. The maximum standardized uptake value (SUVmax) was measured on conventional 18F-FDG PET/CT images. The influx constant (Ki ) was calculated from the dynamic 18F-FDG PET/CT data using Patlak model. Arterial flow (AF) using the maximum slope model and blood volume (BV) using the Patlak plot method for each nodule were calculated from the perfusion CT data. All nodules were characterized as malignant or benign based on histopathology or 2 year follow up CT. All parameters were statistically compared between the two groups using the nonparametric Mann-Whitney test. Results Twelve malignant and 9 benign lung nodules were analysed (median size 20.1 mm, 9–29 mm) in 21 patients (male/female = 11/9; mean age ± SD: 65.3 ± 7.4; age range: 50–76 years). The average SUVmax values ± SD of the benign and malignant nodules were 2.2 ± 1.7 vs. 7.0 ± 4.5, respectively (p = 0.0148). Average Ki values in benign and malignant nodules were 0.0057 ± 0.0071 and 0.0230 ± 0.0155 min-1, respectively (p = 0.0311). Average BV for the benign and malignant nodules were 11.6857 ± 6.7347 and 28.3400 ± 15.9672 ml/100 ml, respectively (p = 0.0250). Average AF for the benign and malignant nodules were 74.4571 ± 89.0321 and 89.200 ± 49.8883 ml/100g/min, respectively (p = 0.1613). Conclusions Dynamic 18F-FDG PET/CT and perfusion CT derived blood volume had similar capability to differentiate benign from malignant lung nodules.

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