scholarly journals 18F-FDG-PET/CT for Evaluation of treatment response in high grade lymphoma

2017 ◽  
Vol 1 (1) ◽  
pp. 42-52
Author(s):  
Yadav Ajay Kumar ◽  
Kumar Rakesh ◽  
Malhotra Arun ◽  
Sharma Atul
Keyword(s):  
Treatment Response ◽  
Fdg Pet ◽  
High Grade ◽  
Predictive Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Ct Data ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct ◽  
Post Therapy

18F-FDG PET is highly sensitive and specific for evaluation of the treatment response of high-grade lymphomas. The molecular information provided by 18F-FDG-PET identifies the functional content of anatomic finding and helps to categorize their nature as malignant or benign. On the other hand, the CT data obtained in the same setting provides anatomical localization of the 18F-FDG-PET data while also improving the FDG-PET image quality as it is utilized for attenuation correction. Previously, most of the studies were done on this topic by using 18F-FDG-PET alone. Present study was planning to assess the role of 18F-FDG-PET/CT in evaluation of treatment response in patient of HD and NHL. Results showed that 43 patients out of 52 showed no pathologic FDG uptakes, whereas 9 showed persistent uptakes. Among the 43 patients who had negative PET scans, only three relapsed, whereas among the 9 patients who had persistent abnormal 18F-FDG uptakes on post therapy PET/CT scans, two recovered. The sensitivity, specificity, positive and negative predictive values and accuracy of post therapy PET/CT scan was 70%, 95%, 78%, 93%, and 90% respectively.

scholarly journals Advantages of 18F-FDG PET/CT Imaging over Modified Duke Criteria and Clinical Presumption in Patients with Challenging Suspicion of Infective Endocarditis

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 720
Author(s):  
Valentin Pretet ◽  
Cyrille Blondet ◽  
Yvon Ruch ◽  
Matias Martinez ◽  
Soraya El Ghannudi ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Predictive Value ◽  
Fdg Pet ◽  
Clinical Suspicion ◽  
Duke Criteria ◽  
High Clinical Suspicion ◽  
Pet Ct ◽  
18F Fdg ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct

According to European Society of Cardiology guidelines (ESC2015) for infective endocarditis (IE) management, modified Duke criteria (mDC) are implemented with a degree of clinical suspicion degree, leading to grades such as “possible” or “rejected” IE despite a persisting high level of clinical suspicion. Herein, we evaluate the 18F-FDG PET/CT diagnostic and therapeutic impact in IE suspicion, with emphasis on possible/rejected IE with a high clinical suspicion. Excluding cases of definite IE diagnosis, 53 patients who underwent 18F-FDG PET/CT for IE suspicion were selected and afterwards classified according to both mDC (possible IE/Duke 1, rejected IE/Duke 0) and clinical suspicion degree (high and low IE suspicion). The final status regarding IE diagnosis (gold standard) was based on the multidisciplinary decision of the Endocarditis Team, including the ‘imaging specialist’. PET/CT images of the cardiac area were qualitatively interpreted and the intensity of each focus of extra-physiologic 18F-FDG uptake was evaluated by a maximum standardized uptake value (SUVmax) measurement. Extra-cardiac 18F-FDG PET/CT pathological findings were considered to be a possible embolic event, a possible source of IE, or even a concomitant infection. Based on the Endocarditis Team consensus, final diagnosis of IE was retained in 19 (36%) patients and excluded in 34 (64%). With a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and global accuracy of 79%, 100%, 100%, 89%, and 92%, respectively, PET/CT performed significantly better than mDC (p = 0.003), clinical suspicion degree (p = 0.001), and a combination of both (p = 0.001) for IE diagnosis. In 41 patients with possible/rejected IE but high clinical suspicion, sensitivity, specificity, PPV, NPV, and global accuracies were 78%, 100%, 100%, 85%, and 90%, respectively. Moreover, PET/CT contributed to patient management in 24 out of 53 (45%) cases. 18F-FDG PET/CT represents a valuable diagnostic tool that could be proposed for challenging IE cases with significant differences between mDC and clinical suspicion degree. 18F-FDG PET/CT allows a binary diagnosis (definite or rejected IE) by removing uncertain diagnostic situations, thus improving patient therapeutic management.

scholarly journals Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Stephanus T. Malherbe ◽  
Ray Y. Chen ◽  
Patrick Dupont ◽  
Ilse Kant ◽  
Magdalena Kriel ◽  
...  
Keyword(s):  
Ct Scan ◽  
Treatment Response ◽  
Fdg Pet ◽  
Tuberculosis Treatment ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

scholarly journals Value of fourth and subsequent post-therapy follow-up 18F-FDG PET/CT scans in patients with breast cancer

2016 ◽  
Vol 37 (6) ◽  
pp. 602-608
Author(s):  
Mehdi Taghipour ◽  
Sara Sheikhbahaei ◽  
Tyler J. Trahan ◽  
Rathan M. Subramaniam
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Ct Scans ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Post Therapy

Diagnosis and assessment of the treatment response in a case of giant cell arteritis using 18F-FDG PET/CT

2012 ◽  
Vol 31 (4) ◽  
pp. 233-235
Author(s):  
I. Martínez-Rodríguez ◽  
R. Del Castillo-Matos ◽  
A. Rubio-Vassallo ◽  
F. Ortega-Nava ◽  
N.A. Martínez-Amador ◽  
...  
Keyword(s):  
Giant Cell Arteritis ◽  
Treatment Response ◽  
Giant Cell ◽  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Role of 18F-FDG PET/CT in Management of High-Grade Salivary Gland Malignancies

2007 ◽  
Vol 48 (8) ◽  
pp. 1237-1244 ◽  
Author(s):  
H.-S. Jeong ◽  
M. K. Chung ◽  
Y.-I. Son ◽  
J. Y. Choi ◽  
H. J. Kim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fdg Pet ◽  
High Grade ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Comparison of the Diagnostic Value of MRI and Whole Body 18F-FDG PET/CT in Diagnosis of Spondylodiscitis

2020 ◽  
Vol 9 (5) ◽  
pp. 1581
Author(s):  
Corinna Altini ◽  
Valentina Lavelli ◽  
Artor Niccoli-Asabella ◽  
Angela Sardaro ◽  
Alessia Branca ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Diagnostic Value ◽  
Whole Body ◽  
Spine Infection ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct ◽  
Ct And Mri

Spondylodiscitis is a spine infection for which a diagnosis by a magnetic resonance imaging (MRI) is considered the most appropriate imaging technique. The aim of this study was to compare the role of an 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and an MRI in this field. For 56 patients with suspected spondylodiscitis for whom MRI and 18F-FDG PET/CT were performed, we retrospectively analyzed the results. Cohen’s κ was applied to evaluate the agreement between the two techniques in all patients and in subgroups with a different number of spinal districts analyzed by the MRI. Sensitivity, specificity, and accuracy were also evaluated. The agreements of the 18F-FDG PET/CT and MRI in the evaluation of the entire population, whole-spine MRI, and two-districts MRI were moderate (κ = 0.456, κ = 0.432, and κ = 0.429, respectively). In patients for whom one-district MRI was performed, 18F-FDG PET/CT and MRI were both positive and completely concordant (κ = 1). We also separately evaluated patients with suspected spondylodiscitis caused by Mycobacterium tuberculosis for whom the MRI and 18F-FDG PET/CT were always concordant excepting in 2 of the 18 (11%) patients. Sensitivity, specificity, and accuracy of the MRI and 18F-FDG PET/CT were 100%, 60%, 97%, and 92%, 100%, and 94%, respectively. Our results confirmed the 18F-FDG PET/CT diagnostic value in the diagnosis of spondylodiscitis is comparable to that of MRI for the entire spine evaluation. This could be considered a complementary technique or a valid alternative to MRI.

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