scholarly journals Value of 18-F-FDG PET/CT and CT in the Diagnosis of Indeterminate Adrenal Masses

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Nathalie Launay ◽  
Stéphane Silvera ◽  
Florence Tenenbaum ◽  
Lionel Groussin ◽  
Frédérique Tissier ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Malignant Tumors ◽  
Apparent Diffusion Coefficient Values ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
Adrenal Masses ◽  
18F Fdg ◽  
Ct Data ◽  
Adrenocortical Carcinomas ◽  
Fdg Pet Ct

The purpose of this paper was to study the value of 18-FDG PET/CT and reassess the value of CT for the characterization of indeterminate adrenal masses. 66 patients with 67 indeterminate adrenal masses were included in our study. CT/MRI images and 18F-FDG PET/CT data were evaluated blindly for tumor morphology, enhancement features, apparent diffusion coefficient values, maximum standardized uptake values, and adrenal-to-liver maxSUV ratio. The study population comprised pathologically confirmed 16 adenomas, 19 metastases, and 32 adrenocortical carcinomas. Macroscopic fat was observed in 62.5% of the atypical adenomas at CT but not in malignant masses. On 18F-FDG PET/CT, SUVmax and adrenal-to-liver maxSUV ratio were significantly lower in adenomas than in malignant tumors. An SUVmax value of less than 3.7 or an adrenal-to-liver maxSUV ratio of less than 1.29 is highly predictive of benignity.

scholarly journals Usefulness of 18F-FDG PET/CT in Patients with Cardiac Implantable Electronic Device Suspected of Late Infection

2020 ◽  
Vol 9 (7) ◽  
pp. 2246
Author(s):  
Giuseppe Rubini ◽  
Cristina Ferrari ◽  
Domenico Carretta ◽  
Luigi Santacroce ◽  
Rossella Ruta ◽  
...  
Keyword(s):  
Predictive Value ◽  
Fdg Pet ◽  
Large Scale ◽  
Electronic Device ◽  
High Sensitivity ◽  
Roc Curves ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

The presence of a cardiovascular implantable electronic device (CIED) can be burdened by complications such as late infections that are associated with significant morbidity and mortality and require immediate and effective treatment. The aim of this study was to evaluate the role of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) in patients with suspected CIED infection. Fifteen patients who performed a 18F-FDG PET/CT for suspicion of CIED infection were retrospectively analyzed; 15 patients, with CIED, that underwent 18F-FDG PET/CT for oncological reasons, were also evaluated. Visual qualitative analysis and semi-quantitative analysis were performed. All patients underwent standard clinical management regardless 18F-FDG PET/CT results. Sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) resulted as 90.91%, 75%, 86.67%, 90.91% and 75% respectively. Maximum standardized uptake values (SUVmax) and semi-quantitative ratio (SQR) were collected and showed differences statistically significant between CIED infected patients and those who were not. Exploratory cut-off values were derived from receiver operating characteristic (ROC) curves for SUVmax (2.56) and SQR (4.15). This study suggests the clinical usefulness of 18F-FDG PET/CT in patients with CIED infection due to its high sensitivity, repeatability and non-invasiveness. It can help the clinicians in decision making, especially in patients with doubtful clinical presentation. Future large-scale and multicentric studies should be conducted to establish precise protocols about 18F-FDG PET/CT performance.

Large adrenal mass heralding the diagnosis of occult extra-adrenal malignancy in two patients

2021 ◽  
Vol 14 (2) ◽  
pp. e239463
Author(s):  
James Anderton ◽  
Marios Ghobrial ◽  
Vasilis Kosmoliaptsis ◽  
Ruth Casey
Keyword(s):  
Fdg Pet ◽  
Adrenal Mass ◽  
Metastatic Carcinoma ◽  
High Avidity ◽  
Positron Emission ◽  
Pet Ct ◽  
Suprarenal Mass ◽  
Adrenal Masses ◽  
18F Fdg ◽  
Fdg Pet Ct

We report two cases highlighting the role of fluorine-18-fluorodeoxyglucose positron emission tomography/computerised tomography (18F FDG PET/CT) in the diagnostic and preoperative workup of indeterminate adrenal masses. Case 1: a 60-year-old man was diagnosed with a large left-sided adrenal mass with indeterminate radiological characteristics on CT. Biochemical investigations ruled out tumour hypersecretion. 18F FDG PET/CT was performed to exclude metastases and identified a pulmonary nodule in the left upper lobe. Histology of the resected adrenal tumour demonstrated a secondary metastasis from an adenocarcinoma of the lung. Case 2: an 88-year-old male was found to have a heterogeneous and vascular left-sided suprarenal mass and a smaller right-sided adrenal nodule. Both adrenal nodules had indeterminate radiological characteristics. Biochemical investigations were negative. PET/CT demonstrated high avidity in the bilateral adrenal nodules but no extra-adrenal FDG avid disease. Histology demonstrated a metastatic carcinoma of pulmonary origin.

18F-FDG PET/CT in the evaluation of adrenal masses in lung cancer patients

Neoplasma ◽  
2010 ◽  
Vol 57 (2) ◽  
pp. 129-134 ◽  
Author(s):  
Y. Lu ◽  
D. Xie ◽  
W. Huang ◽  
H. Gong ◽  
J. Yu
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Fdg Pet ◽  
Lung Cancer Patients ◽  
Pet Ct ◽  
Adrenal Masses ◽  
18F Fdg ◽  
Fdg Pet Ct

Inter-comparison of 18F-FDG PET/CT standardized uptake values in Korea

2011 ◽  
Vol 69 (1) ◽  
pp. 241-246 ◽  
Author(s):  
Hoon Hee Park ◽  
Dae Sung Park ◽  
Dae Cheol Kweon ◽  
Sang Bock Lee ◽  
Ki Baek Oh ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals 18F-FDG-PET/CT for Evaluation of treatment response in high grade lymphoma

2017 ◽  
Vol 1 (1) ◽  
pp. 42-52
Author(s):  
Yadav Ajay Kumar ◽  
Kumar Rakesh ◽  
Malhotra Arun ◽  
Sharma Atul
Keyword(s):  
Treatment Response ◽  
Fdg Pet ◽  
High Grade ◽  
Predictive Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Ct Data ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct ◽  
Post Therapy

18F-FDG PET is highly sensitive and specific for evaluation of the treatment response of high-grade lymphomas. The molecular information provided by 18F-FDG-PET identifies the functional content of anatomic finding and helps to categorize their nature as malignant or benign. On the other hand, the CT data obtained in the same setting provides anatomical localization of the 18F-FDG-PET data while also improving the FDG-PET image quality as it is utilized for attenuation correction. Previously, most of the studies were done on this topic by using 18F-FDG-PET alone. Present study was planning to assess the role of 18F-FDG-PET/CT in evaluation of treatment response in patient of HD and NHL. Results showed that 43 patients out of 52 showed no pathologic FDG uptakes, whereas 9 showed persistent uptakes. Among the 43 patients who had negative PET scans, only three relapsed, whereas among the 9 patients who had persistent abnormal 18F-FDG uptakes on post therapy PET/CT scans, two recovered. The sensitivity, specificity, positive and negative predictive values and accuracy of post therapy PET/CT scan was 70%, 95%, 78%, 93%, and 90% respectively.

Whole-body MR-DWIBS vs. [18F]-FDG-PET/CT in the study of malignant tumors: a retrospective study

2011 ◽  
Vol 117 (2) ◽  
pp. 293-311 ◽  
Author(s):  
D. Cafagna ◽  
G. Rubini ◽  
F. Iuele ◽  
N. Maggialetti ◽  
A. Notaristefano ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Fdg Pet ◽  
Malignant Tumors ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on 18F-FDG PET/CT

2013 ◽  
Vol 40 (2) ◽  
pp. 206-213 ◽  
Author(s):  
Karen A. Büsing ◽  
Stefan O. Schönberg ◽  
Joachim Brade ◽  
Klaus Wasser
Keyword(s):  
Blood Glucose ◽  
Fdg Pet ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals CXCR4-Directed PET/CT in Patients with Newly Diagnosed Neuroendocrine Carcinomas

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 605
Author(s):  
Alexander Weich ◽  
Rudolf A. Werner ◽  
Andreas K. Buck ◽  
Philipp E. Hartrampf ◽  
Sebastian E. Serfling ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Cxcr4 Expression ◽  
Reference Standard ◽  
Diagnostic Potential ◽  
Pet Tracer ◽  
Standardized Uptake Values ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Neuroendocrine Carcinomas

We aimed to elucidate the diagnostic potential of the C-X-C motif chemokine receptor 4 (CXCR4)-directed positron emission tomography (PET) tracer 68Ga-Pentixafor in patients with poorly differentiated neuroendocrine carcinomas (NEC), relative to the established reference standard 18F-FDG PET/computed tomography (CT). In our database, we retrospectively identified 11 treatment-naïve patients with histologically proven NEC, who underwent 18F-FDG and CXCR4-directed PET/CT for staging and therapy planning. The images were analyzed on a per-patient and per-lesion basis and compared to immunohistochemical staining (IHC) of CXCR4 from PET-guided biopsies. 68Ga-Pentixafor visualized tumor lesions in 10/11 subjects, while18F-FDG revealed sites of disease in all 11 patients. Although weak to moderate CXCR4 expression could be corroborated by IHC in 10/11 cases, 18F-FDG PET/CT detected significantly more tumor lesions (102 vs. 42; total lesions, n = 107; p < 0.001). Semi-quantitative analysis revealed markedly higher 18F-FDG uptake as compared to 68Ga-Pentixafor (maximum and mean standardized uptake values (SUV) and tumor-to-background ratios (TBR) of cancerous lesions, SUVmax: 12.8 ± 9.8 vs. 5.2 ± 3.7; SUVmean: 7.4 ± 5.4 vs. 3.1 ± 3.2, p < 0.001; and, TBR 7.2 ± 7.9 vs. 3.4 ± 3.0, p < 0.001). Non-invasive imaging of CXCR4 expression in NEC is inferior to the reference standard 18F-FDG PET/CT.

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