scholarly journals A design of forceps-type coincidence radiation detector for intraoperative LN diagnosis: clinical impact estimated from LNs data of 20 esophageal cancer patients

2021 ◽  
Author(s):  
Miwako Takahashi ◽  
Shuntaro Yoshimura ◽  
Sodai Takyu ◽  
Susumu Aikou ◽  
Yasuhiro Okumura ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Detector ◽  
Radiation Detection ◽  
Statistical Error ◽  
Clinical Impact ◽  
Coincidence Detection ◽  
Detection Sensitivity ◽  
Scintillation Crystals ◽  
Positron Emission ◽  
Better Than

Abstract Purpose To reduce postoperative complications, intraoperative lymph node (LN) diagnosis with 18F-fluoro-2-deoxy-D-glucose (FDG) is expected to optimize the extent of LN dissection, leading to less invasive surgery. However, such a diagnostic device has not yet been realized. We proposed the concept of coincidence detection wherein a pair of scintillation crystals formed the head of the forceps. To estimate the clinical impact of this detector, we determined the cut-off value using FDG as a marker for intraoperative LN diagnosis in patients with esophageal cancer, the specifications needed for the detector, and its feasibility using numerical simulation. Methods We investigated the dataset including pathological diagnosis and radioactivity of 1073 LNs resected from 20 patients who underwent FDG-positron emission tomography followed by surgery for esophageal cancer on the same day. The specifications for the detector were determined assuming that it should measure 100 counts (less than 10% statistical error) or more within the intraoperative measurement time of 30 s. The detector sensitivity was estimated using GEANT4 simulation and the expected diagnostic ability was calculated. Results The cut-off value was 620 Bq for intraoperative LN diagnosis. The simulation study showed that the detector had a radiation detection sensitivity of 0.96%, which was better than the estimated specification needed for the detector. Among the 1035 non-metastatic LNs, 815 were below the cut-off value. Conclusion The forceps-type coincidence detector can provide sufficient sensitivity for intraoperative LN diagnosis. Approximately 80% of the prophylactic LN dissections in esophageal cancer can be avoided using this detector.

Modern Staging and Utility of PET Imaging in Esophageal Cancer Management

2008 ◽  
Vol 6 (9) ◽  
pp. 862-869 ◽  
Author(s):  
Kwang-Yu Chang ◽  
Jang-Yang Chang ◽  
Joseph Chao ◽  
Yun Yen
Keyword(s):  
Esophageal Cancer ◽  
Neoadjuvant Therapy ◽  
Imaging System ◽  
False Negative ◽  
Lymph Node Involvement ◽  
Cancer Management ◽  
Positron Emission ◽  
Node Involvement ◽  
Positive Results ◽  
Locoregional Lymph Node

Esophageal cancer is the eighth most common cancer worldwide, and one of the most fatal diseases despite modern medical treatment. Because correct staging and surveillance of neoadjuvant therapy for esophageal cancer is mandatory for further treatment planning, choosing a modern imaging system is important. The development of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) has provided alternate means of tumor detection distinct from more conventional methods. This modality has extraordinary performance in detecting locoregional lymph node involvement and distant metastatic disease, and has been introduced as a powerful tool in many guidelines. However, some factors still lead to false-negative or -positive results, raising questions of its accuracy. This article discusses the clinical efficacy of PET in staging and surveillance of neoadjuvant therapy in esophageal cancer, comparing its accuracy with conventional imaging modalities.

Clinical impact of FDG-PET on the management of esophageal cancer

2004 ◽  
Vol 11 (S2) ◽  
pp. S53-S54 ◽  
Author(s):  
C. P. Duong ◽  
H. Demitriou ◽  
A. Thompson ◽  
L. Weih ◽  
W. A. Phillips ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Fdg Pet ◽  
Clinical Impact

Scheme design and key technology verification of Narrow Angle Sensor for small body mission

2021 ◽  
Author(s):  
Fenzhi Wu ◽  
Xiao Liang ◽  
Yanpeng Wu ◽  
Yunfang Zhang ◽  
Yuan Zhao ◽  
...  
Keyword(s):  
Autonomous Navigation ◽  
Measurement Accuracy ◽  
Small Body ◽  
Spectral Observation ◽  
Detection Sensitivity ◽  
Composition Analysis ◽  
Processing Unit ◽  
Scientific Observation ◽  
Exploration Mission ◽  
Better Than

<p>   In small body exploration mission, the uncertainty of the target characteristics and the special weak gravitational environment put forward higher requirements for the optical autonomous navigation accuracy of the probe and the detection ability of the navigation sensor. Narrow Angel Sensor(Hereinafter referred to as NAS), as the key instrument of China’s first small body exploration mission, has both optical autonomous navigation function and scientific observation ability, and it must give consideration to both near and far, and achieve breakthroughs in dynamic range, detection sensitivity, pointing measurement accuracy, angular resolution and spectral observation ability. The specific performance is as follows: To capture and track Near Earth Asteroids 2016HO3 from tens of thousands of kilometers, NAS is required to have the ability of point target detection, and the detection sensitivity is better than MV10, and  the accuracy of pointing measurement is better than 1 ″. As the probe approaches the target, NAS must be able to clearly image the shape and surface texture of 2016HO3, so as to obtain the motion parameters such as the spin axis and rotation period of the target. In remote sensing and descending stage, the mission requires NAS to be able to carry out global centimeter scale and landing area millimeter scale multi-spectral observation of the target, and optical navigation uses high-resolution images to construct landmark feature library, so as to realize terrain relative navigation; meanwhile, the image is used to provide data support for the scientific research of the target topography, spectral characteristics and surface material composition analysis.</p> <p>   NAS adopts split design, and the detector part is composed of front door, baffle, focusing optical system, filter wheel, image processing circuit, and motor drive circuit, the algorithm is implemented in the image navigation processing unit. The prototype of the instruments has been developed, and the function and performances such as MTF, detection sensitivity, pointing measurement accuracy etc were verified. The instrument achieved expected design objectives,  and can meet the requirements of optical autonomous navigation and scientific observation for China’s small body exploration mission.</p>

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