Push-Pull Osmotic Pumps Using Crosslinked Hard Gelatin Capsule as a Structural Assembly for Delivery of Drugs with Different Water Solubilities

2021 ◽  
Author(s):  
Chaowalit Monton ◽  
Poj Kulvanich
Keyword(s):  
Gelatin Capsule ◽  
Osmotic Pumps ◽  
Hard Gelatin Capsule ◽  
Structural Assembly

Capsule-related dysphagia and the use of netupitant/palonosetron (Akynzeo™) capsules – A report of two cases and a solution

2020 ◽  
pp. 107815522096567
Author(s):  
Kevin Behbahany ◽  
Joseph Bubalo
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Fixed Combination ◽  
Nausea And Vomiting ◽  
Gelatin Capsule ◽  
Hard Gelatin Capsule ◽  
Experienced Difficulty

Netupitant/palonestron (NEPA, Akynzeo™) is a fixed combination of netupitant 300 mg and palonosetron 0.5 mg that is indicated for the prevention of chemotherapy-induced nausea and vomiting (CINV). NEPA is supplied as a hard gelatin capsule and indicated to be administered whole with or without food. The efficacy of NEPA was maintained when administered as an oral dose of netupitant given concomitantly (in separate formulations after removal from the hard gelatin capsule) with a single oral dose of palonosetron. At our institution, two patients experienced difficulty swallowing the capsule leading to opening the capsule and individual administration of the medications. We observed that the efficacy was maintained when the opened NEPA capsule was administered as individual medications. We report the details of these two patient cases.

Method for Monitoring Hard Gelatin Capsule Disintegration Times in Humans Using External Scintigraphy

1976 ◽  
Vol 65 (9) ◽  
pp. 1412-1413 ◽  
Author(s):  
Dennis L. Casey ◽  
Robert M. Beihn ◽  
George A. Digenis ◽  
Manvendra B. Shambhu
Keyword(s):  
Gelatin Capsule ◽  
Hard Gelatin Capsule
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