Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma

2015 ◽  
Vol 22 (3) ◽  
pp. 541-547 ◽  
Author(s):  
Dongfeng Qiao ◽  
Ming Li ◽  
Juan Pu ◽  
Wanwei Wang ◽  
Weiguo Zhu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Tyrosine Phosphatase ◽  
Clinical Course ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Aggressive Clinical Course

The role of protein tyrosine phosphatase non-receptor 11 (PTPN11) mutations in lung squamous cell carcinoma (SQCC).

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e22174-e22174
Author(s):  
Yasir Elamin ◽  
Sinead Toomey ◽  
Aoife Carr ◽  
Kenneth O'Byrne ◽  
Shereen Rafee ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Lung Squamous Cell Carcinoma ◽  
Protein Tyrosine

scholarly journals Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene

2011 ◽  
Vol 131 (3) ◽  
pp. E216-E226 ◽  
Author(s):  
Sally R. Lambert ◽  
Catherine A. Harwood ◽  
Karin J. Purdie ◽  
Abha Gulati ◽  
Rubeta N. Matin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Receptor Type ◽  
Protein Tyrosine ◽  
Type D

Protein tyrosine phosphatase receptor R and Z1 expression as independent prognostic indicators in oral squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 37 (12) ◽  
pp. 1816-1822 ◽  
Author(s):  
Kamila Duś-Szachniewicz ◽  
Marta Woźniak ◽  
Kamil Nelke ◽  
Elżbieta Gamian ◽  
Hanna Gerber ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Prognostic Indicators ◽  
Protein Tyrosine

scholarly journals Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma

2013 ◽  
Vol 104 (8) ◽  
pp. 1120-1126 ◽  
Author(s):  
Won-Sik Shin ◽  
Junhye Kwon ◽  
Hae Won Lee ◽  
Moon Chul Kang ◽  
Hye-Won Na ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
Protein Tyrosine Kinase 7

scholarly journals Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

2010 ◽  
Vol 25 (6) ◽  
pp. 513-517 ◽  
Author(s):  
Roseana de Almeida Freitas ◽  
Ericka Janine Dantas Silveira ◽  
João Paulo Borges da Silveira ◽  
Fabyanne Mazutti da Silva ◽  
Rivadávio Fernandes Batista de Amorim
Keyword(s):  
Squamous Cell Carcinoma ◽  
Quantitative Analysis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tumor Metastasis ◽  
Clinical Course ◽  
Negative Score ◽  
Positive Score ◽  
Aggressive Clinical Course

PURPOSE: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of β-catenin in OSCC of the tongue and its correlation with tumor metastasis. METHODS: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the β-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). RESULTS: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. CONCLUSIONS: Based on these results, it can be concluded that the immunoexpression of β-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue.

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