scholarly journals Clinical Utility of Tc-99m MIBI SPECT/CT for Preoperative Localization of Parathyroid Lesions

2016 ◽  
Vol 79 (4) ◽  
pp. 312-318 ◽  
Author(s):  
Zeynep Gozde Ozkan ◽  
Seher Nilgun Unal ◽  
Serkan Kuyumcu ◽  
Yasemin Sanli ◽  
Mehmet Fatih Gecer ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Preoperative Localization ◽  
Parathyroid Lesions ◽  
Mibi Spect

Efficacy of Ultrasonography and Tc-99m MIBI SPECT/CT in Preoperative Localization of Parathyroid Adenomas Causing Primary Hyperthyroidism

2021 ◽  
Author(s):  
Ruigang Lu ◽  
Wei Zhao ◽  
Li Yin ◽  
Ruijun Guo ◽  
Bojun Wei ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Diagnostic Performance ◽  
Preoperative Localization ◽  
Clinical Value ◽  
Parathyroid Adenomas ◽  
Significant Difference ◽  
Parathyroid Lesions ◽  
The Difference ◽  
Primary Hyperthyroidism ◽  
Mibi Spect

Abstract Background: Primary hyperparathyroidism (PHPT) results from an excess of parathyroid hormone (PTH) produced from an overactive parathyroid gland. The study aimed to explore the sonographic features of parathyroid adenomas and assess the diagnostic performance of ultrasonography (US) and Tc-99m MIBI SPECT/CT for preoperative localization of parathyroid adenomas. Methods: A total of 107 patients were enrolled in this retrospective study who had PHPT and underwent parathyroidectomy. Of the 107 patients, 97 performed US and Tc-99m MIBI SPECT/CT examinations for preoperative localization of parathyroid nodules. The sensitivity and accuracy of each modality were calculated. Results: In this study, residual parathyroid sign and polar vascular sign were identified as characteristic US features of parathyroid adenomas and these manifestations are closely related to the size of the abnormal parathyroid lesions. Using 108 parathyroid nodules from 97 patients with PHPT, the sensitivity and accuracy of US in locating parathyroid nodules were significantly higher than those of Tc-99m MIBI SPECT/CT (93.0% vs. 63.0% and 88.0% vs. 63.0%), and the difference was statistically significant (c²=26.224, 18.227, P<0.001). The difference between US combined with Tc-99m MIBI SPECT/CT and Tc-99m MIBI SPECT/CT-alone was statistically significant (c²=33.410, 21.587, P<0.001), yet there was no significant difference compared with US alone (c²=0.866, 0.187, P=0.352 and 0.665). Conclusions: US shows significantly better sensitivity and accuracy for localization of parathyroid adenomas than Tc-99m MIBI SPECT/CT. However, US combined with Tc-99m MIBI SPECT/CT is of great clinical value in the preoperative localization of parathyroid nodules in patients with PHPT.

scholarly journals Factors That Affect the Sensitivity of Imaging Modalities in Primary Hyperparathyroidism

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Minting Zhu ◽  
Yang He ◽  
Tingting Liu ◽  
Bei Tao ◽  
Weiwei Zhan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Primary Hyperparathyroidism ◽  
Preoperative Localization ◽  
Imaging Modalities ◽  
Emission Computed Tomography ◽  
Imaging Results ◽  
Parathyroid Lesions ◽  
99Mtc Mibi ◽  
Serum Pth ◽  
Mibi Spect

Background. Cervical ultrasound, 99mTc-sestamibi single-photon emission computed tomography/computed tomography (99mTc-MIBI SPECT/CT), and cervical CT are routinely used in preoperative localization of primary hyperparathyroidism (PHPT). However, false-negative imaging results are also frequently encountered in clinical practice. Exploring the factors that affect the sensitivity of these imaging modalities is important for the surgical management of PHPT patients. Methods. Clinical data of 352 PHPT patients hospitalized in our center from January 2011 to December 2015 were retrospectively collected to evaluate the sensitivity of 3 imaging modalities in the preoperative localization of parathyroid lesions. The ROC curve analysis was used to explore the clinical factors affecting the sensitivity of localization, and the cut-point(s) of related factors were determined. Results. 99mTc-MIBI SPECT/CT has the highest sensitivity among the localization modalities commonly used, reaching 91.1% (86.0%–94.8%). When the lengths of parathyroid lesions were ≤1.3 cm, the sensitivity of neck ultrasonography significantly decreased, while the sensitivity of 99mTc-MIBI SPECT/CT decreased with parathyroid lesions ≤1.3 cm or serum PTH≤252 pg/ml. 99mTc-MIBI SPECT/CT was less effective in localizing the hyperplasia lesions. Neck ultrasonography combined with 99mTc-MIBI SPECT/CT can effectively improve the accuracy of preoperative localization of parathyroid lesions to 96.2% (92.7%–98.1%). Conclusions. Small parathyroid lesion and mild elevation of serum PTH would reduce the accuracy of parathyroid localization in PHPT patients.

scholarly journals Efficacy of ultrasonography and Tc-99m MIBI SPECT/CT in preoperative localization of parathyroid adenomas causing primary hyperthyroidism

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruigang Lu ◽  
Wei Zhao ◽  
Li Yin ◽  
Ruijun Guo ◽  
Bojun Wei ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Retrospective Study ◽  
Primary Hyperparathyroidism ◽  
Diagnostic Performance ◽  
Preoperative Localization ◽  
Clinical Value ◽  
Parathyroid Adenomas ◽  
Parathyroid Lesions ◽  
Primary Hyperthyroidism ◽  
Mibi Spect

Abstract Background Primary hyperparathyroidism (PHPT) results from an excess of parathyroid hormone (PTH) produced from an overactive parathyroid gland. The study aimed to explore the sonographic features of parathyroid adenomas and assess the diagnostic performance of ultrasonography (US) and Tc-99m MIBI SPECT/CT for preoperative localization of parathyroid adenomas. Methods A total of 107 patients were enrolled in this retrospective study who had PHPT and underwent parathyroidectomy. Of the 107 patients, 97 performed US and Tc-99m MIBI SPECT/CT examinations for preoperative localization of parathyroid nodules. The sensitivity and accuracy of each modality were calculated. Results In this study, residual parathyroid sign and polar vascular sign were identified as characteristic US features of parathyroid adenomas. These manifestations were closely related to the size of the abnormal parathyroid lesions. Among the 108 parathyroid nodules from 97 patients with PHPT, the sensitivity and accuracy of US for locating the parathyroid nodules were significantly higher than those of Tc-99m MIBI SPECT/CT (93.0% vs. 63.0% and 88.0% vs. 63.0% respectively; χ2 = 26.224, 18.227 respectively, P < 0.001). The differences between US + Tc-99m MIBI SPECT/CT and Tc-99m MIBI SPECT/CT-alone were statistically significant (χ2 = 33.410, 21.587 respectively, P < 0.001), yet there were no significant differences in the sensitivity or accuracy between US + Tc-99m MIBI SPECT/CT and US-alone (χ2 = 0.866, 0.187 respectively, P = 0.352 and 0.665). Conclusions US shows significantly better sensitivity and accuracy for localization of parathyroid adenomas than Tc-99m MIBI SPECT/CT. However, US combined with Tc-99m MIBI SPECT/CT is of great clinical value in the preoperative localization of parathyroid nodules in patients with PHPT.

The value of parathyroid hormone determination in ultrasound-guided fine-needle aspirates (FNA-PTH) for preoperative localization of parathyroid lesions.

2014 ◽  
Author(s):  
Magdalena Kochman ◽  
Waldemar Misiorowski ◽  
Lucyna Papierska ◽  
Elzbieta Stachlewska-Nasfeter ◽  
Witold Chudzinski ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Preoperative Localization ◽  
Ultrasound Guided ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Parathyroid Lesions

Mid-mediastinal parathyroid lesions: Preoperative localization and surgical approach in two cases

1990 ◽  
Vol 20 (4) ◽  
pp. 481-486 ◽  
Author(s):  
Takao Obara ◽  
Yoshihide Fujimoto ◽  
Reiko Tanaka ◽  
Yukio Ito ◽  
Takaya Kodama ◽  
...  
Keyword(s):  
Surgical Approach ◽  
Preoperative Localization ◽  
Parathyroid Lesions ◽  
Mediastinal Parathyroid

The role of ultrasound elastography in preoperative localization of parathyroid lesions: a new assisting method to preoperative parathyroid ultrasonography

2012 ◽  
Vol 76 (4) ◽  
pp. 492-498 ◽  
Author(s):  
Uğur Ünlütürk ◽  
Murat Faik Erdoğan ◽  
Özgür Demir ◽  
Cavit Çulha ◽  
Sevim Güllü ◽  
...  
Keyword(s):  
Ultrasound Elastography ◽  
Preoperative Localization ◽  
Parathyroid Lesions

scholarly journals Diagnostic value of Sestamibi Scan in the preoperative localization of parathyroid lesions in patients with primary hyperparathyroidism.

2020 ◽  
Vol 8 (1) ◽  
pp. 47-47
Author(s):  
Babak Mahmoudian ◽  
Mitra Tootoonchian ◽  
Amir Bahrami ◽  
Zhila Khamnian
Keyword(s):  
Primary Hyperparathyroidism ◽  
Predictive Value ◽  
Clinical Decision Making ◽  
High Sensitivity ◽  
Diagnostic Value ◽  
Preoperative Localization ◽  
Preoperative Imaging ◽  
Cross Sectional ◽  
Sestamibi Scan ◽  
Parathyroid Lesions

Abstract Introduction: Preoperative localization modalities for patients with primary hyperparathyroidism today play an important role in clinical decision making, surgical procedure, and the prognosis of patients. One of the most common preoperative imaging modalities is the sestamibi scan labeled with Technetium-99m, which is capable of determining the location of parathyroid lesions in primary hyperparathyroidism patients with high sensitivity. Methods: In this cross-sectional study, 25 patients with primary hyperparathyroidism, referred to endocrine clinic of Tabriz University of Medical Siences during 2016-2018 were enrolled. All patients underwent a preoperative Sestamibi scan. Comparing the results of the scan with the surgical findings as a standard gold method for diagnosis, the diagnostic value of the scan was evaluated for the localization of parathyroid lesions. Results: According to the items observed in surgery and pathologic findings, the sensitivity of Sestamibi scan for the localization of parathyroid lesions was 84.6%. Specificity and positive predictive value and negative predictive value were 95.6%, 89.6%, and 94.8%, respectively. A significant relationship was observed between the type of lesion and the sensitivity of Sestamibi scan (p=0.002). Conclusion: Sestamibi scan has high sensitivity and diagnostic and therapeutic value for patients with primary hyperparathyroidism. However, the existence of other pre- and intraoperative localization modalities, at the request of surgeons, is useful and warranted to reduce the rate of recurrent surgery as well as to minimize false negatives.

Sign in / Sign up

Export Citation Format

Share Document