scholarly journals Regulation des Angstverhaltens — zur Rolle neuronaler Netzwerke

BIOspektrum ◽  
2019 ◽  
Vol 25 (7) ◽  
pp. 711-714
Author(s):  
Nina Dedic ◽  
Jan M. Deussing
Keyword(s):  
Stress Response ◽  
Ventral Tegmental Area ◽  
Long Range ◽  
Dopamine Release ◽  
Receptor Type ◽  
Projection Neurons ◽  
Neuronal Circuit ◽  
Brain Reward ◽  
Crh Receptor Type 1

AbstractThe corticotropin-releasing hormone (CRH) system orchestrates the organism’s stress response including the regulation of adaptive be haviours. Here we describe a novel neuronal circuit, which acts anxiety suppressing and positively modulates dopamine release. This anxiolytic circuit comprises inhibitory CRH-expressing, long-range projection neurons within the extended amygdala. These neurons innervate the ventral tegmental area, a prominent brain reward center that expresses high levels of CRH receptor type 1.

Chronic alcoholism influences the mRNA level of the orexin receptor type 1 (OX1R) in emotiogenic structures of the rat brain

2018 ◽  
Vol 64 (5) ◽  
pp. 451-454 ◽  
Author(s):  
M.I. Airapetov ◽  
E.A. Sekste ◽  
S.O. Eresko ◽  
E.R. Bychkov ◽  
A.A. Lebedev ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ventral Tegmental Area ◽  
Alcohol Withdrawal ◽  
Alcohol Intoxication ◽  
Mrna Level ◽  
Receptor Type ◽  
Intact Control ◽  
Chronic Alcoholization ◽  
Ventral Tegmental

Orexin and its receptors were shown to be involved into mechanisms of pathological craving to alcohol. This paper demonstrates that the orexin receptor type 1 (OX1R) mRNA level significantly decreased in the prefrontal cortex of rats chronically (during 6 months) consuming ethanol compared with intact control. The same results were observed on day 1 and day 7 of alcohol withdrawal after chronic alcoholization. On the contrary, in the hippocampus, the OX1R mRNA level increased on day 1 and day 7 of alcohol withdrawal. In the ventral tegmental area, the OX1R mRNA level did not change on the day 1 and day 7 of alcohol withdrawal compared with the groups of chronic alcoholization and intact control. These findings point out involvement of the prefrontal cortex and hippocampus first of all in mechanisms mediating chronic alcohol intoxication. The ventral tegmental area is described as a typical dopaminergic structure providing the executive mechanism of emotion reactions connected with alcohol abuse in particular. It is possibe, that the modulating action of orexins on dopaminergic neurons in this structure does not provide a significant effect on control of emotion reactions in alcoholism.

Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1β and response to PKC phosphorylation

2008 ◽  
Vol 20 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Thalia Teli ◽  
Danijela Markovic ◽  
Margaret E. Hewitt ◽  
Michael A. Levine ◽  
Edward W. Hillhouse ◽  
...  
Keyword(s):  
Receptor Type ◽  
Structural Domains ◽  
Crh Receptor Type 1

scholarly journals Reduced expression of CRH receptor type 1 in upper segment human myometrium during labour

2009 ◽  
Vol 7 (1) ◽  
pp. 43 ◽  
Author(s):  
Binhai Cong ◽  
Lanmei Zhang ◽  
Lu Gao ◽  
Xin Ni
Keyword(s):  
Receptor Type ◽  
Human Myometrium ◽  
Crh Receptor Type 1

scholarly journals Consolidation of Remote Fear Memories Involves Corticotropin-Releasing Hormone (CRH) Receptor Type 1-Mediated Enhancement of AMPA Receptor GluR1 Signaling in the Dentate Gyrus

2011 ◽  
Vol 37 (3) ◽  
pp. 787-796 ◽  
Author(s):  
Christoph K Thoeringer ◽  
Kathrin Henes ◽  
Matthias Eder ◽  
Maik Dahlhoff ◽  
Wolfgang Wurst ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Ampa Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Crh Receptor Type 1

scholarly journals CRH Acts on CRH-R1 and -R2 to Differentially Modulate the Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Pregnant Myometrium

Endocrinology ◽  
2011 ◽  
Vol 152 (11) ◽  
pp. 4406-4417 ◽  
Author(s):  
Chen Xu ◽  
Lu Gao ◽  
Xingji You ◽  
Ling Dai ◽  
Yuan Li ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Receptor Type ◽  
Uterine Contractility ◽  
Myometrial Cells ◽  
Calcium Activated Potassium Channels ◽  
Spontaneous Contractions ◽  
Crh Receptor Type 1 ◽  
Interfering Rna

CRH has been implicated to play a key role in the control of human pregnancy and parturition. Large-conductance potassium channels (BKCa) play a pivotal role in the modulation of uterine contractility during pregnancy. The objectives of the present study were to investigate the effect of CRH on BKCa expression in human pregnant myometrial cells. Myometrial tissues were collected at cesarean section from pregnant women not-in-labor (TNL) or in-labor (TL) at term, and myocytes were isolated and cultured. CRH was identified in human pregnant myometrium and mainly expressed in myometrial myocytes. Cultured myometrial cells were able to secrete CRH. In TNL myometrial cells, CRH treatment increased the expression of BKCa α- and β-subunits. CRH receptor type 1 (CRH-R1) antagonist, antalarmin, decreased whereas CRH receptor type 2 (CRH-R2) antagonist, astressin2b, increased the expression of BKCa. CRH-R2 small interfering RNA (siRNA) caused an increase, but CRH-R1 siRNA resulted in a decrease, in BKCa expression. In contrast to TNL cells, CRH exhibited an opposite effect on BKCa expression in TL myometrial cells, i.e. decreased BKCa expression. Antalarmin enhanced but astressin2b reduced BKCa expression. CRH-R2 siRNA decreased whereas CRH-R1 siRNA increased BKCa expression. 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one significantly inhibited the frequency of spontaneous contractions of myometrial strips, and this effect was significantly decreased in TL strips compared with TNL ones. Our data suggest that CRH-R1 and CRH-R2 show differential regulation of BKCa expression. These effects mediated by CRH-R1 and CRH-R2 are changed after the onset of labor. This leads us to suggest that CRH may fine-tune myometrial contractility by modulating the expression of BKCa during pregnancy and labor.

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