Cardioprotective effects of the novel Na+/H+ exchanger-1 inhibitor KR-32560 in a perfused rat heart model of global ischemia and reperfusion: Involvement of the Akt-GSK-3β cell survival pathway and antioxidant enzyme

2010 ◽  
Vol 33 (8) ◽  
pp. 1241-1251 ◽  
Author(s):  
In-Sang Jung ◽  
Sung-Hun Lee ◽  
Min-Kyu Yang ◽  
Jung-Woo Park ◽  
Kyu-Yang Yi ◽  
...  
Keyword(s):  
Cell Survival ◽  
Antioxidant Enzyme ◽  
Rat Heart ◽  
Ischemia And Reperfusion ◽  
The Novel ◽  
Heart Model ◽  
Perfused Rat Heart ◽  
Survival Pathway ◽  
Cardioprotective Effects ◽  
Gsk 3Β

Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart

1991 ◽  
Vol 204 (2) ◽  
pp. 171-177 ◽  
Author(s):  
Ohta Hideo ◽  
Jinno Yasuhiro ◽  
Harada Katsuhiko ◽  
Ogawa Nobuyuki ◽  
Fukushima Hideaki ◽  
...  
Keyword(s):  
Rat Heart ◽  
Perfused Rat Heart ◽  
Cardioprotective Effects

scholarly journals Cardioprotective Effects of 9-Hydroxyellipticine on Ischemia and Reperfusion in Isolated Rat Heart

2002 ◽  
Vol 89 (1) ◽  
pp. 21-28 ◽  
Author(s):  
Kazuhiko Saeki ◽  
Ichiro Obi ◽  
Noriko Ogiku ◽  
Munekazu Shigekawa ◽  
Toshiaki Imagawa ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Ischemia And Reperfusion ◽  
Cardioprotective Effects ◽  
Isolated Rat

scholarly journals Use of the Isolated Perfused Heart for Evaluation of Cardiac Toxicity

1990 ◽  
Vol 18 (4a) ◽  
pp. 497-510 ◽  
Author(s):  
Peter G. Anderson ◽  
Stanley B. Digerness ◽  
Jerald L. Sklar ◽  
Paul J. Boor
Keyword(s):  
Rat Heart ◽  
Coronary Flow ◽  
Systolic Pressure ◽  
Left Ventricular ◽  
Heart Weight ◽  
Isolated Perfused Heart ◽  
Heart Model ◽  
Perfused Heart ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart

The isolated perfused rat heart model can be used to evaluate cardiotoxicity, and is especially useful in distinguishing direct vs indirect cardiac injury. Various perfusion systems can be used to characterize the pathophysiologic as well as morphologic changes induced by drugs or chemicals of interest. The isolated perfused heart was used in the studies described herein to characterize the mechanism of allylamine cardiotoxicity. Rat hearts were perfused with Krebs-Henseleit buffer containing 10 mm allylamine and a latex balloon was inserted into the left ventricle to monitor pressure. Coronary flow in hearts perfused with 10 mm allylamine was similar to control hearts at 5, 10, and 30 min, but was reduced by 1 hr (11.5 ± 0.6 ml/min/g wet heart weight vs 16.0 ± 0.7, p < 0.01). Peak left ventricular systolic pressure increased in hearts perfused with allylamine for 5 min (156 ± 8 mm Hg vs 103 ± 9, p < 0.01), but by 2 hr was decreased compared to controls (89 ± 6 vs 105 ± 5, p < 0.05). End diastolic pressure was markedly increased at 2 hr (58 ± 3 vs 4 ± 0.8, p < 0.01). Morphologically, allylamine perfused hearts exhibited significant contraction band changes as well as numerous cells with marked swelling of the sarcoplasmic reticulum. The findings in this study suggest that allylamine produces direct myocardial damage that appears to be independent of coronary flow. These studies demonstrate that the isolated perfused rat heart model can be used to evaluate mechanisms of acute cardiotoxicity.

Cardioprotective Effect of Zofenopril in Perfused Rat Heart Subjected to Ischemia and Reperfusion

2004 ◽  
Vol 43 (2) ◽  
pp. 294-299 ◽  
Author(s):  
Sabina Frascarelli ◽  
Sandra Ghelardoni ◽  
Simonetta Ronca-Testoni ◽  
Riccardo Zucchi
Keyword(s):  
Rat Heart ◽  
Cardioprotective Effect ◽  
Ischemia And Reperfusion ◽  
Perfused Rat Heart
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