The Airway Colonization by Opportunistic Filamentous Fungi in Patients with Cystic Fibrosis: Recent Updates

2014 ◽  
Vol 8 (4) ◽  
pp. 302-311 ◽  
Author(s):  
Kada Touati ◽  
Do Ngoc Linh Nguyen ◽  
Laurence Delhaes
Keyword(s):  
Cystic Fibrosis ◽  
Filamentous Fungi ◽  
Airway Colonization

scholarly journals Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France

2010 ◽  
Vol 48 (O1) ◽  
pp. S32-S36 ◽  
Author(s):  
André Paugam ◽  
Marie-Thérèse Baixench ◽  
Nadine Demazes-Dufeu ◽  
Pierre-Régis Burgel ◽  
Elise Sauter ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Filamentous Fungi ◽  
Adult Patients ◽  
Airway Colonization

Chronic airway colonization by Penicillium emersonii in a patient with cystic fibrosis

1999 ◽  
Vol 37 (4) ◽  
pp. 291-293 ◽  
Author(s):  
B. Cimon ◽  
J. Carrere ◽  
J. P. Chazalette ◽  
J. F. Vinatier ◽  
D. Chabasse ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Airway Colonization ◽  
Chronic Airway

Filamentous fungi in the airway of patients with cystic fibrosis: Just spectators?

2021 ◽  
Author(s):  
Clara Viñado ◽  
Rosa María Girón ◽  
Elisa Ibáñez ◽  
Alberto García-Ortega ◽  
Inés Pérez ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Filamentous Fungi

scholarly journals Chronic Airway Colonization byAchromobacter xylosoxidansin Cystic Fibrosis Patients Is Not Sustained by Their Domestic Environment

2018 ◽  
Vol 84 (23) ◽  
Author(s):  
Chloé Dupont ◽  
Estelle Jumas-Bilak ◽  
Clara Doisy ◽  
Fabien Aujoulat ◽  
Raphaël Chiron ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Tract ◽  
Antimicrobial Agents ◽  
Patient Specific ◽  
Achromobacter Xylosoxidans ◽  
Opportunistic Pathogens ◽  
Domestic Environment ◽  
Content Type ◽  
Domestic Environments ◽  
Airway Colonization

ABSTRACTAchromobacterspp. are nonfermentative Gram-negative bacilli considered emergent pathogens in cystic fibrosis (CF). Although some cross-transmission events between CF patients have been described,Achromobacterstrains were mostly patient specific, suggesting sporadic acquisitions from nonhuman reservoirs. However, sources of these emergent CF pathogens remain unknown. A large collection of specimens (n= 273) was sampled in the homes of 3 CF patients chronically colonized byAchromobacter xylosoxidanswith the aim of evaluating the potential role of domestic reservoirs in sustaining airway colonization of the patients. Samples were screened for the presence ofAchromobacterby using genus-specific molecular detection. Species identification, multilocus genotypes, and antimicrobial susceptibility patterns observed for environmental isolates were compared with those of clinical strains. Patient homes hosted a high diversity ofAchromobacterspecies (n= 7), includingAchromobacter mucicolensandA. animicus, two species previously isolated from human samples only, and genotypes (n= 15), all showing an overall susceptibility to antimicrobial agents.Achromobacterstrains were mostly isolated from indoor moist environments and siphons, which are potential reservoirs for several CF emerging pathogens.A. xylosoxidans, the worldwide prevalent species colonizing CF patients, was not the majorAchromobacterspecies inhabiting domestic environments.A. xylosoxidansgenotypes chronically colonizing the patients were not detected in their household environments. These results support the notions that the domestic environment could not be incriminated in sustained patient colonization and that after initial colonization, the environmental survival ofA. xylosoxidansclones adapted to the CF airways is probably impaired.IMPORTANCEAchromobacterspp. are worldwide emerging opportunistic pathogens in CF patients, able to chronically colonize the respiratory tract. Apart from regular consultations at the hospital CF center, patients spend most of their time at home. Colonization from nonhuman sources has been suggested, but the presence ofAchromobacterspp. in CF patients' homes has not been explored. The domestic environments of CF patients chronically colonized byAchromobacter, especially wet environments, host several opportunistic pathogens, including a large diversity ofAchromobacterspecies and genotypes. However,Achromobactergenotypes colonizing the patients were not detected in their domestic environments, making it unlikely that a shuttle between environment and CF airways is involved in persisting colonization. This also suggests that once the bacteria have adapted to the respiratory tract, their survival in the domestic environment is presumably impaired. Nevertheless, measures for reducing domestic patient exposure should be targeted on evacuation drains, which are frequently contaminated by CF opportunistic pathogens.

Chronic airway colonization by Penicillium emersonii in a patient with cystic fibrosis

2008 ◽  
Vol 37 (4) ◽  
pp. 291-293
Author(s):  
B. Cimon ◽  
J. Carrere ◽  
J. P. Chazalette ◽  
J. F. Vinatier ◽  
D. Chabasse ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Airway Colonization ◽  
Chronic Airway

scholarly journals Draft Genome Sequence of a blaNDM-1- and blaPME-1-Harboring Pseudomonas aeruginosa Clinical Isolate from Pakistan

2019 ◽  
Vol 8 (17) ◽  
Author(s):  
Sidra Irum ◽  
Robert F. Potter ◽  
Rubina Kamran ◽  
Zeeshan Mustafa ◽  
Meghan A. Wallace ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Genome Sequencing ◽  
Draft Genome ◽  
Whole Genome ◽  
Beta Lactamase ◽  
Content Type ◽  
Extended Spectrum Beta Lactamase ◽  
Carbapenem Resistant ◽  
Airway Colonization

We performed Illumina whole-genome sequencing on a carbapenem-resistant Pseudomonas aeruginosa strain isolated from a cystic fibrosis patient with chronic airway colonization. The draft genome comprises 6,770,411 bp, including the carbapenemase bla NDM-1 and the extended-spectrum beta-lactamase bla PME-1.

scholarly journals Local innate host response and filamentous fungi in patients with cystic fibrosis

2010 ◽  
Vol 48 (O1) ◽  
pp. S22-S31 ◽  
Author(s):  
Emmanuel Roilides ◽  
Maria Simitsopoulou
Keyword(s):  
Cystic Fibrosis ◽  
Filamentous Fungi ◽  
Host Response

scholarly journals Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis – a review

2009 ◽  
Vol 47 (4) ◽  
pp. 387-397 ◽  
Author(s):  
Marc Pihet ◽  
Jacqueline Carrere ◽  
Bernard Cimon ◽  
Dominique Chabasse ◽  
Laurence Delhaes ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Filamentous Fungi
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