scholarly journals Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer

Breast Cancer ◽  
2019 ◽  
Vol 26 (5) ◽  
pp. 628-636
Author(s):  
Fumi Kato ◽  
Kohsuke Kudo ◽  
Hiroko Yamashita ◽  
Motoi Baba ◽  
Ai Shimizu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Lymph Nodes ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Luminal A ◽  
Apparent Diffusion Coefficient Value ◽  
Apparent Diffusion

scholarly journals Prediction of Early Response to Chemotherapy in Breast Cancer Liver Metastases by Diffusion-Weighted MR Imaging

2019 ◽  
Vol 18 ◽  
pp. 153303381984294 ◽  
Author(s):  
Genji Bai ◽  
Yating Wang ◽  
Yan Zhu ◽  
Lili Guo
Keyword(s):  
Breast Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Liver Metastases ◽  
Early Response ◽  
Apparent Diffusion Coefficient Values ◽  
Apparent Diffusion Coefficient Value ◽  
Response To Chemotherapy ◽  
Apparent Diffusion ◽  
Breast Cancer Liver Metastases

Objective: To determine whether change in apparent diffusion coefficient value could predict early response to chemotherapy in breast cancer liver metastases. Materials and Methods: We retrospectively studied 42 patients (86 lesions) with breast cancer liver metastases who had undergone conventional magnetic resonance imaging and diffusion-weighted imaging (b = 0.700 s/mm2) before and after chemotherapy. Maximum diameter and mean apparent diffusion coefficient value (×10−3 mm2/s) of liver metastases from breast cancer were evaluated. The grouping reference was based on magnetic resonance imaging according to Response Evaluation Criteria in Solid Tumors (RECIST). Analysis of variance and receiver–operating characteristic analyses were performed. Results: Eighty-six metastases were classified as 40 responders and 46 nonresponders. A statistically significant correlation was found between prechemotherapy and postchemotherapy apparent diffusion coefficient values in responders, which were 0.9 ± 0.16 × 10−3 mm2/s, 1.05 ± 0.12 × 10−3 mm2/s, 1.26 ± 0.12 × 10−3 mm2/s, and 1.33 ± 0.87 × 10−3 mm2/s, respectively. No statistically significant difference was found between prechemotherapy and postchemotherapy apparent diffusion coefficient values in nonresponders. Differences were statistically significant between responders and nonresponders at prechemotherapy, 2 weeks after chemotherapy, and 4 weeks after chemotherapy ( P = 0.014, P = .001, and P = .000, respectively). Receiver operating characteristic curves showed that apparent diffusion coefficient values could predict treatment response early at 2 weeks after chemotherapy with 64.5% sensitivity and 91.8% specificity. Conclusion: The change in apparent diffusion coefficient value may be a sensitive indicator to predict early response to chemotherapy in breast cancer liver metastases.

scholarly journals Differences in the Immune Response of the Nonmetastatic Axillary Lymph Nodes Between Triple-Negative and Luminal A Breast Cancer Surrogate Subtypes

2020 ◽  
Author(s):  
Carlos López ◽  
Albert Gibert-Ramos ◽  
Ramón Bosch ◽  
Anna Korzynska ◽  
Marcial García-Rojo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune Response ◽  
Lymph Nodes ◽  
Triple Negative ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Luminal A
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