scholarly journals Effect of hemodialysis on circulating cystatin c levels in patients with end stage renal disease

2010 ◽  
Vol 25 (1) ◽  
pp. 43-46 ◽  
Author(s):  
N. Krishnamurthy ◽  
K. Arumugasamy ◽  
U. Anand ◽  
C. V. Anand ◽  
V. Aruna ◽  
...  
Keyword(s):  
Renal Disease ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis

2020 ◽  
Author(s):  
Shaohui Ma ◽  
Ming Zhang ◽  
Yang Liu ◽  
Dun Ding ◽  
Peng Li ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Renal Disease ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Neuropsychological Tests ◽  
Maintenance Hemodialysis ◽  
Rich Club ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Abstract Background End-stage renal disease (ESRD) patients are at substantially higher risk for developing cognitive impairment compared with the healthy population. Dialysis is an essential way to maintain the life of ESRD patients. Based on previous research, there did not provide an uncontested result whether cognition was improved or worsened during dialysis. Methods To explore the impact of dialysis treatment on cognitive performance, we recruited healthy controls (HCs), ESRD patients before dialysis initiation (bESRD) and those undergoing maintenance hemodialysis (mESRD). All ESRD patients performed a serious of blood biochemistry tests (hemoglobin, urea, cystatin C, Na+, K + and parathyroid hormone). Neuropsychological tests were used to measure cognitive function. By using diffusion tensor imaging and graph-theory approaches, the topological organization of the whole-brain structural network was investigated. Generalized linear models (GLMs) were performed to investigate blood biochemistry predictors of the neuropsychological tests and the results of graph analyses in mESRD and bESRD groups. Results Neuropsychological analysis showed mESRD exhibited greater cognitive function than bESRD, but both were worse than HCs. Whole-brain graph analyses revealed that increased global efficiency and normalized shortest path length remained in the bESRD and mESRD than the HCs. Besides, lower normalized clustering coefficient was in bESRD relative to the HCs and mESRD. For the GLMs analysis, only the Cystatin C level was significantly associated with the average fiber length of rich club connections in bESRD. Conclusions Our study revealed that dialysis had a limited effect on cognitive improvement. Cystatin C may be a risk feature of cognitive decline of bESRD.

scholarly journals Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis

2020 ◽  
Author(s):  
Shaohui Ma ◽  
Ming Zhang ◽  
Yang Liu ◽  
Dun Ding ◽  
Peng Li ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Renal Disease ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Neuropsychological Tests ◽  
Maintenance Hemodialysis ◽  
Rich Club ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Abstract Background: End-stage renal disease (ESRD) patients are at a substantially higher risk for developing cognitive impairment compared with the healthy population. Dialysis is an essential way to maintain the life of ESRD patients. Based on previous research, there isn’t an uncontested result whether cognition was improved or worsened during dialysis.Methods: To explore the impact of dialysis treatment on cognitive performance, we recruited healthy controls (HCs), predialysis ESRD patients (predialysis group), and maintenance hemodialysis ESRD patients (HD group). All ESRD patients performed six blood biochemistry tests (hemoglobin, urea, cystatin C, Na+, K+, and parathyroid hormone). Neuropsychological tests were used to measure cognitive function. By using diffusion tensor imaging and graph-theory approaches, the topological organization of the whole-brain structural network was investigated. Generalized linear models (GLMs) were performed to investigate blood biochemistry predictors of the neuropsychological tests and the results of graph analyses in the HD group and predialysis group.Results: Neuropsychological analysis showed the HD group exhibited better cognitive function than the predialysis group, but both were worse than HCs. Whole-brain graph analyses revealed that increased global efficiency and normalized shortest path length remained in the predialysis group and HD group than the HCs. Besides, a lower normalized clustering coefficient was found in the predialysis group relative to the HCs and HD group. For the GLM analysis, only the Cystatin C level was significantly associated with the average fiber length of rich club connections in the predialysis group.Conclusions: Our study revealed that dialysis had a limited effect on cognitive improvement.

Abstract 022: Cystatin C Strengthens the Association of Kidney Function with Mortality and End-Stage Renal Disease

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Michael G Shlipak ◽  
Kunihiro Matsushita ◽  
Johan Ärnlöv ◽  
Lesley A Inker ◽  
Ronit Katz ◽  
...  
Keyword(s):  
General Population ◽  
Renal Disease ◽  
Serum Creatinine ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Diverse Populations ◽  
Net Reclassification Improvement ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Impact

Background: Adding cystatin C to serum creatinine improves accuracy of estimated glomerular filtration rate (eGFR), but the impact on detection, staging and prognosis of chronic kidney disease (CKD) across diverse populations has not been determined. Methods: Meta-analyses including 11 general population cohorts (N=90,750 participants) and 5 CKD cohorts (N=2,960) with standardized serum creatinine and cystatin C at baseline. We compared associations of baseline GFR estimated by CKD-EPI equations using creatinine (eGFR cr ) vs. cystatin C (eGFR cys ) with mortality (13,202 deaths from 15 cohorts) and incident end-stage renal disease (ESRD) (1,654 cases from 7 cohorts) during mean follow-up of 7.7 years and studied prognostic consequences of reclassification. Results: In the general population cohorts, mean eGFRs were 85 ml/min/1.73m 2 for both equations but prevalence of eGFR<60 ml/min/1.73m 2 was higher for eGFR cys vs. eGFR cr (13.7% vs. 9.7% [12,403 vs. 8,833 of 90,750]). Across all eGFR cr categories (≥90, 60-89, 45-59, 30-44, 15-29, and <15 ml/min/1.73m 2 ), upward and downward reclassification by eGFR cys was associated with lower and higher risk, respectively; net reclassification improvement for eGFR cys compared with eGFR cr was 0.23 (0.18-0.28) for mortality and 0.10 (0.00-0.21) for ESRD. Among participants with eGFR cr 45-59 ml/min/1.73m 2 (N=6,358), ~40% were reclassified to higher eGFR cys categories and had lower risks of mortality (adjusted hazard ratio 0.66; 95% CI 0.57-0.77) and ESRD (0.20; 0.08-0.53) compared to those who were not reclassified. Among participants with eGFR cr 60-89 ml/min/1.73m 2 (N=43,630), ~13% were reclassified to lower eGFR cys categories and had higher risk for mortality (1.57; 1.39-1.78) and ESRD (2.66; 1.52-4.67) compared to no reclassification. The results for CKD cohorts were largely similar. Conclusions: Cystatin C strengthens the association of eGFR with risk across diverse populations providing a potentially useful adjunct to eGFR cr for detection and staging of CKD.

scholarly journals Serum Concentration of Cystatin C and Risk of End-Stage Renal Disease in Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 35 (11) ◽  
pp. 2311-2316 ◽  
Author(s):  
A. S. Krolewski ◽  
J. H. Warram ◽  
C. Forsblom ◽  
A. M. Smiles ◽  
L. Thorn ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Renal Disease ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Comparative Study of Serum Cystatin C and Serum Creatinine Level in Before and After Hemodialysis

2021 ◽  
pp. 102-106
Author(s):  
Dattu Hawale ◽  
Ranjit Ambad ◽  
Nandkishor Bankar ◽  
Raunak Kotecha
Keyword(s):  
Renal Disease ◽  
Serum Creatinine ◽  
Comparative Study ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Serum Cystatin C ◽  
Creatinine Concentration ◽  
Serum Cystatin ◽  
Stage Renal Disease ◽  
End Stage

Background: Chronic kidney disease (CKD) is a pathophysiologic process characterised by a decrease in nephron number and function, which often leads to end-stage renal disease (ESRD). Serum plasma cystatin C is a new test for determining kidney function. Its accuracy in determining the efficacy of haemodialysis in patients with end-stage renal disease has yet to be determined. Serum cystatin C, which is formed at a constant rate by all nucleated cells and filtered freely by the glomerulus, is neither secreted nor reabsorbed, and is unaffected by non-renal influences. Materials and Methods: This study was a comparative study, conducted in the nephrology Department at DMMC & SMHRC, Nagpur in collaboration with ABVRH and JNMC Wardha, Sawangi (Meghe) during September 2020 to March 2021. Total 25 patient (End stage renal disease) included for the present study, the age group 30-60 years with 17 male patients and 08 female patients. Result: Serum creatinine concentration in the before hemodialysis with 8.72±3.00 and for the after hemodialysis 3.20±1.18(P < 0.0001). The serum cystatin C concentration in the before hemodialysis 5.50±2.09 and for the after hemodialysis 8.7±1.75(P < 0.0001). the process of hemodialysis leads to a significantly low in a serum creatinine concentration as compared to before hemodialysis. The serum cystatin C concentration significantly increase in the after hemodialysis patient as compared to before hemodialysis. Conclusion: Hemodialysis adequacy cannot be determined using serum cystatin C. It does, however, serve as a surrogate marker of dialysis inadequacy, particularly when low flux membranes are used. Routine examination of serum cystatin C in hemodialysis patients will help in the monitoring of the patient's overall clinical condition.

Levels of cystatin C in low- and high-flux hemodialysis in children with end-stage renal disease

2017 ◽  
Vol 32 (9) ◽  
pp. 1603-1609
Author(s):  
Fatina I. Fadel ◽  
Abbass A. Mourad ◽  
Azza M. O. Abdel Rahman ◽  
Hafez M. Bazaraa ◽  
Mohamed Farouk Mohamed ◽  
...  
Keyword(s):  
Renal Disease ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
High Flux ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Abnormal rich club organization in end-stage renal disease patients before dialysis initiation and undergoing maintenance hemodialysis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Shaohui Ma ◽  
Ming Zhang ◽  
Yang Liu ◽  
Dun Ding ◽  
Peng Li ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Renal Disease ◽  
Cystatin C ◽  
End Stage Renal Disease ◽  
Neuropsychological Tests ◽  
Maintenance Hemodialysis ◽  
Rich Club ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients

Abstract Background End-stage renal disease (ESRD) patients are at a substantially higher risk for developing cognitive impairment compared with the healthy population. Dialysis is an essential way to maintain the life of ESRD patients. Based on previous research, there isn’t an uncontested result whether cognition was improved or worsened during dialysis. Methods To explore the impact of dialysis treatment on cognitive performance, we recruited healthy controls (HCs), predialysis ESRD patients (predialysis group), and maintenance hemodialysis ESRD patients (HD group). All ESRD patients performed six blood biochemistry tests (hemoglobin, urea, cystatin C, Na+, K+, and parathyroid hormone). Neuropsychological tests were used to measure cognitive function. By using diffusion tensor imaging and graph-theory approaches, the topological organization of the whole-brain structural network was investigated. Generalized linear models (GLMs) were performed to investigate blood biochemistry predictors of the neuropsychological tests and the results of graph analyses in the HD group and predialysis group. Results Neuropsychological analysis showed the HD group exhibited better cognitive function than the predialysis group, but both were worse than HCs. Whole-brain graph analyses revealed that increased global efficiency and normalized shortest path length remained in the predialysis group and HD group than the HCs. Besides, a lower normalized clustering coefficient was found in the predialysis group relative to the HCs and HD group. For the GLM analysis, only the Cystatin C level was significantly associated with the average fiber length of rich club connections in the predialysis group. Conclusions Our study revealed that dialysis had a limited effect on cognitive improvement.

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