scholarly journals Factors Affecting Canagliflozin-Induced Transient Urine Volume Increase in Patients with Type 2 Diabetes Mellitus

2016 ◽  
Vol 34 (2) ◽  
pp. 436-451 ◽  
Author(s):  
Hiroyuki Tanaka ◽  
Kazuhiko Takano ◽  
Hiroaki Iijima ◽  
Hajime Kubo ◽  
Nobuko Maruyama ◽  
...  
2020 ◽  
Vol 40 ◽  
pp. 101228
Author(s):  
Nursyuhadah Othman ◽  
Yuet Yen Wong ◽  
Qi Ying Lean ◽  
Nurain Mohd Noor ◽  
Chin Fen Neoh

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223431 ◽  
Author(s):  
Takeshi Horii ◽  
Kenji Momo ◽  
Takeo Yasu ◽  
Yusuke Kabeya ◽  
Koichiro Atsuda

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Yoshiichi Takagi ◽  
Taichi Sugimoto ◽  
Masaya Kobayashi ◽  
Mitsuyuki Shirai ◽  
Fumitoshi Asai

High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks. Systolic blood pressure and urine volume were increased in WBKDF-HS and Wistar-HS. Body weight gain and food consumption were comparable between NS and HS in both strains. Plasma and urine glucose levels were significantly increased in WBKDF-NS but not in WBKDF-HS. HOMA-IR in WBKDF-HS was significantly lower compared with that in WBKDF-NS. The high plasma adiponectin level in WBKDF-NS compared with that in Wistar-NS was further enhanced in WBKDF-HS. Glycogen deposits and fat droplets in the livers of WBKDF-HS were reduced compared with those of WBKDF-NS. The present study demonstrated that HS intake ameliorated hyperglycemia and insulin resistance in WBKDF rats, which may be due to increased plasma levels of adiponectin.


2005 ◽  
Vol 96 (1) ◽  
pp. 129-132 ◽  
Author(s):  
Mikayo Ando ◽  
Shinichiro Ando ◽  
Toshiaki Takeuchi

We studied 50 Japanese patients who were first diagnosed with type 2 diabetes mellitus. Psychological functioning was assessed by using the Rorschach test and the Yatabe-Guilford Personality test. Analysis indicated that patients who discontinued clinic attendance during the 2-yr. study period had more depression, lower general activity and less extraversion, more negative self-attitudes, and more concern about being helpless than those who continued having regular followups. This study also found that patients who had worse glycemic control 2 yr. after being first diagnosed reported more inferiority feelings, lower general activity, more need for closeness to others, and more emotional demands than those who had better glycemic control. In conclusion, understanding the psychological functioning would be helpful in the management of Japanese patients with type 2 diabetes mellitus.


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