general activity
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Author(s):  
Oleksii Polkovnikov ◽  
◽  
Sergii Pavlov ◽  
Igor Belenichev ◽  
Nataliya Matolinets ◽  
...  

Purpose of the article: to study the effect of acelysine and nimodipine on certain endothelial dysfunction indicators and to evaluate their therapeutic efficacy after subarachnoid hemorrhage in rats. Materials and Methods: an experimental study was carried out using 50 Wistar rats of both sexes. Spontaneous subarachnoid hemorrhage was modeled in animals. Three groups of animals were identified: a control group, a group of animals received a standard therapeutic dose of acelysine, and a group received a standard therapeutic dose of nimotop. Each group included 15 animals. There were also 5 intact animals. The animals were withdrawn from the experiment on days 4 and 7 after the motor and exploratory activity determination. Motor and exploratory activity determination was carried out following SAH with the “Open Field” technique. Determination of biochemical markers of endothelial dysfunction was performed in a rat brain homogenate. Results and discussion. It was found that modeling of subarachnoid hemorrhage (SAH) led to the oxidative stress development development and the product of oxidative modification of proteins (nitrotyrosine (Ntz) on the 4th and especially on the 7th day of the experiment) increase in the brain tissues. Starting from the 4th day, we registered a compensatory increase in the activity of NO-synthase (NOS) - by 56%, followed by a decrease in its activity on the 7th day, by more than 33% against the intact group of animals. It was registered a compensatory increase in VEGF-A in rats with SAH modeling on the 4th day of the experiment and its further decrease on the 7th day. The established pathobiochemical changes in the brain tissue were accompanied by the cognitive deficit development in experimental animals, especially on the 7th day of the SAH. SAH led to a significant decrease in the total activity of animals by 2.63 times, a decrease in the distance traveled by animals by 1.89 times, the number of freezes increased by 1.86 times and the immobility of animals increased when moving from the periphery to the center and immobility in the center of the arena (anxiety, fear, disorientation), as well as a decrease in the distance traveled and the speed of movement in illuminated center of the arena 2 and 2.6 times, respectively. Experimental therapy with acelysine 15 mg/kg led to the normalization of biochemical indicators of endothelial dysfunction: concentration of nitrotyrosine, starting from the 4th day of the experiment, increased eNOS activity and VEGF-A concentration (by 75% and 64% on 7th day). The administration of namidopine led to less pronounced effects, statistically significant changes occurred only in relation to the VEGF-A concentration. Administration of namidopine resulted in only a slight increase in VEGF-A concentration. Acelysine and nimotope significantly increased the total activity of rats on the 7th day after SAH by 76.3% and 48.8%, respectively. In animals treated with acelysine, anxiety and fear decreased. The animals were less aggressive and more empathic - long-term grooming increased 3 times. The administration of nimotop in rats survived SAH had a less pronounced positive effect on behavior. Nimotop did not effect on indicators of general activity and did not increase the total distance traveled. Animals received nimtop were inactive by the 7th day of treatment. Conclusions: Experimental therapy with acelysine led to the normalization of biochemical parameters of endothelial dysfunction, namely nitrotyrosine concentration, starting from the 4th day of the experiment and increased eNOS activity and VEGF-A concentration. It should be noted that, in contrast to the rats of the control group, under prescription of acelysine, there was an increase in the concentration of eNOS and VEGF-A both on the 4th and 7th days of the experiment. The administration of namidopine led to less pronounced effects, statistically significant changes occurred only in relation to the VEGF-A concentration. The administration of acelysin to animals after SAH had a beneficial effect on the emotional status and behavior of animals, and also led to the normalization of their general activity and orientation-exploratory activity. The mechanism of edotheliotropic effect of acelysine, in our opinion, is associated with its antioxidant effects, modulating impact on endothelial NOS, as well as its property, indirectly, to influence on increase VEGF content. Nimotope therapy had no effect on the emotional status and behavior of the animals. The use of calcium channel blockers revealed such side effects as depression, drowsiness, diplopia, and disorientation


2021 ◽  
Vol 13 (47) ◽  
pp. 130-131
Author(s):  
Veronika Wittmann ◽  
Victória Arrifano ◽  
Vanessa Gallego Arias Pecorari ◽  
Ezequiel Paulo Viriato ◽  
Leoni Villano Bonamin ◽  
...  

Introduction: The factors related to obesity are complex, involving biologic, environmental and neuropsychological mechanisms[1-3]. Among the factors which influence the gain of weight, we can consider the stressful factors. Aims: The aim of this experiment was to evaluate the influence of the commercial homeopathic product compound by Fucus vesiculosus 1cH, Thyroidinum 5cH and Calcarea carbonica 5cH (Besomed®) in the gain of weight in animals submitted to hypercaloric diet and stress. Materials and Methods 40 male freshly weaned Wistar rats, ingesting hypercaloric food, were divided into 4 groups, being two groups submitted to stress by standstill, being one group treated and the other one for control (vehicle) and two more groups without stress being one treated and the other one for control. All were given the drink water ad libidum, in blind, for 2 months. The general activity was evaluated by the Open Field method in 2 steps, one after stress and one after 1 month of treatment. The weekly gain of weight was measured during the whole period of treatment. The data were analyzed by the ANOVA method of two ways followed by the Bonferroni test[4], being p≤0,05. Results: The treatment with Besomed® was effective in reducing only the gain of weight in the animals submitted to stress (p≤0,05); the evaluation of general activity in the Open Field showed increase in the time of freezing of these same animals after receiving the stressful stimulus. Discussion: The medicine is used as auxiliary in obesity treatment, and has the same both endogenous highdiluted molecules as the medicine used by similarity, which is the case of Calcarea carbonica, which, among others is indicated for obesity and hyperlipidemia[5], being observed in this study that the homeopathic complex group gained less weight than the other groups. Stress is capable of disturbing the physiological and psychological homeostasia of an individual, and when the stress is caused by standstill, it may induce behavior of the anxious type. There are also studies relating anxiety and feeding behavior in chronically stressed[6] individuals, showing that consuming a hypercaloric diet induces an anxious behavior[7] in male rats. In this study was not observed any change in the motor activity of animals which passed stress, however the time of freezing of the animals which took Besomed® was the lowest (p≤0,05) after stress, if compared to the control groups, demonstrating the absence of an anxious behavior. Conclusion: The medicine evaluated was effective in reducing weight and in inducing an adaptive behavior only in the stressed animals, reducing the evaluated parameters to the same levels observed in the control group.


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jae Hwan Cho ◽  
Chang Ju Hwang ◽  
Dong-Ho Lee ◽  
Choon Sung Lee

Abstract Background Although the original technique involves inserting two cages bilaterally, there could be situations that only allow for insertion of one cage unilaterally. However, only a few studies have compared the outcomes between unilateral and bilateral cage insertion. The purpose of this study was to compare the clinical and radiological outcomes in patients who underwent posterior lumbar interbody fusion (PLIF) between unilaterally and bilaterally inserted cages. Methods Among 206 eligible patients who underwent 1- or 2-level PLIF, 78 patients were 1:3 cohort-matched by age, sex, and operation level (group U, 19 patients with unilateral cages; and group B, 57 patients with bilateral cages). Fusion status was evaluated by computed tomography (CT) scans at postoperative 1 year. Clinical outcomes were measured by visual analog scale (VAS), Oswestry Disability Index (ODI), and EQ-5D. Radiological and clinical parameters were compared between the two groups. Risk factors for pseudarthrosis were also analyzed by multivariate analysis. Results The demographic data were not significantly different between the two groups. However, previous laminectomy, asymmetric disc collapse, and fusion at L5-S1 level were more frequently found in group U (P = 0.003, P = 0.014, and P = 0.014, respectively). Furthermore, pseudarthrosis was more frequently observed in group U (36.8%) than in group B (7.0%) (P = 0.004). Back pain VAS was higher in group U at postoperative 1 year (P = 0.033). Lower general activity function of EQ-5D was observed in group U at postoperative 1 year (P = 0.035). Older age (P = 0.028), unilateral cage (P = 0.007), and higher bone mineral density (P = 0.033) were positively correlated with pseudarthrosis. Conclusions Unilaterally inserted cage might be a possible risk factor for pseudarthrosis when performing PLIF, which could be related with the difficult working conditions such as scars due to previous laminectomy or asymmetric disc collapse. Furthermore, suboptimal clinical outcomes are expected following PLIF with unilateral cage insertion at postoperative 1 year regardless of similar clinical outcomes at postoperative 2 year. Therefore, caution is advised when inserting cages unilaterally, especially under above-mentioned conditions in terms of its possible relationship with symptomatic pseudarthrosis.


Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1375
Author(s):  
Patrícia Roberta dos Santos ◽  
Carolina Rodrigues Mendonça ◽  
Matias Noll ◽  
Cezimar Correia Borges ◽  
Polissandro Mortoza Alves ◽  
...  

Although pain is a frequent complaint of patients with chronic kidney disease who undergo hemodialysis, few studies have assessed the functional interference of pain in activities of daily living (ADLs). Hence, the aim of this study was to evaluate the prevalence, location, intensity, and functional interference of pain in ADLs of chronic kidney disease patients undergoing hemodialysis and to estimate the association of specific pain sites with severe functional interference by pain in ADLs. This cross-sectional study included patients with chronic kidney disease undergoing hemodialysis. The prevalence, intensity, and functional interference of pain in ADLs were assessed using the brief pain inventory. Poisson regression was used to calculate the prevalence ratio. A total of 65 patients participated in the study. The overall prevalence of pain was 89.23%; the prevalence of headache was 18.46% and that of pain in the trunk was 55.38%, upper limbs was 35.38%, and lower limbs was 60.00%. The prevalence of moderate and severe pain at the time of hemodialysis was 13.85% and 21.54%, respectively. A high prevalence of severe functional interference of pain in general activity (61.54%), mobility (56.92%), and disposition (55.38%) was observed. Pain is a frequent complaint in patients undergoing hemodialysis, mainly musculoskeletal and intradialytic, and it interferes with ADLs and incapacitates the patient. Pain was highly prevalent in the upper and lower limbs and the trunk. Furthermore, a higher prevalence of severe pain at the time of hemodialysis and functional interference of pain, mainly in general activity, mobility, and disposition, were observed.


2021 ◽  
Vol 7 (10) ◽  
pp. 420-424

This article considers peculiarities of deixis and anaphora in speech discourse. The author of the article believes that the separation of deictic and anaphora relations as independent objects of research in linguistics is associated with the consideration of the problems of deixis as a category of general activity theory, communicative-functional, pragmatic and cognitive linguistics, and anaphora as a category of text/discourse linguistics, which provides its structural-syntactic and semantic coherence. This explains the transition from the study of the characteristics of syntactic anaphora, mainly pronouns, within the sentence/utterance to the consideration of text / discourse anaphora.


2021 ◽  
Vol 9 (9) ◽  
pp. 1877
Author(s):  
Vladimir Mironov ◽  
Anna Vanteeva ◽  
Diyana Sokolova ◽  
Alexander Merkel ◽  
Yury Nikolaev

Mechanical-biological treatment of municipal solid waste (MSW) facilitates reducing the landfill workload. The current research aimed to study general activity parameters, content, functions, and diversity of fungal and prokaryotic microbiota in mechanically separated organic fraction of MSW (ms-OFMSW) composting, without using bulking agents and process-promoting additives. During 35 days of composting, vigorous emission of CO2 (max. 129.4 mg CO2 kg−1 h−1), NH3 (max. 0.245 mg NH3 kg−1 h−1), and heat release (max. 4.28 kJ kg−1 h−1) occurred, indicating intense microbial activity. Immediately following the preparation of the composting mixture, eight genera of lactic acid bacteria and fungal genera Rhizopus, Aspergillus, Penicillium, Agaricus, and Candida were predominant. When the temperature increased to more than 60 °C, the microbial biodiversity decreased. Due to succession, the main decomposers of ms-OFMSW changed. The Bacillaceae family, the genera Planifilum, Thermobifida, and Streptomyces, and the fungal genera Thermomyces and Microascus were involved in the processes of organic matter mineralization at the high-temperature and later stages. The biodiversity of the microbiota increased at the stages of cooling and maturation under conditions of relatively high nitrogen content. Thus, the microbial community and its succession during ms-OFMSW composting were characterized for the first time in this work.


Author(s):  
Kacper Niburski ◽  
Natalie Buu

Introduction: Applicants to specialty programs lack guidance on knowing what exactly is desired by selection committees and program directors. Anesthesia is especially opaque, given its failure to provide transparency reports nationally. This study was developed to survey Canadian anesthesia program directors about the aspects of the application package desired in an anesthesia applicant. The primary objective is to identify the preferred attributes of anesthesia applications by those mandating the selection committees. Methods: Survey was developed via Google Surveys, and sent online over a period of two months in June and July 2020. All program directors were sent requests for filling in the survey. STATA was used for all statistical analyses. Two analyses, Mann-Whitney and ANOVA tests, were performed for comparison groups. A p < 0.05 was considered significant. Results: Fourteen of seventeen (83%) Canadian anesthesia program directors completed the survey. Having done an anesthesia elective, good performance in it, and excellence of preclinical academic performance were considered among the most important aspects of the application package with the highest ranking important and smallest standard deviation. Any form of red flag was also considered an important criterion, again with little variation among program directors. The reference letters selected by the applicants were also important, with a personal relationship and well written reference being identified as most important (p < 0.05). Conclusions: An applicant who has good academic performance, having anesthesia elective experience, personal, well-written reference letters, and general activity and interests that are not necessarily anesthesia-focused would be favoured by Canadian anesthesia programs.


Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 670
Author(s):  
Mingzheng Hou ◽  
Song Liu ◽  
Jiliu Zhou ◽  
Yi Zhang ◽  
Ziliang Feng

Activity recognition is a fundamental and crucial task in computer vision. Impressive results have been achieved for activity recognition in high-resolution videos, but for extreme low-resolution videos, which capture the action information at a distance and are vital for preserving privacy, the performance of activity recognition algorithms is far from satisfactory. The reason is that extreme low-resolution (e.g., 12 × 16 pixels) images lack adequate scene and appearance information, which is needed for efficient recognition. To address this problem, we propose a super-resolution-driven generative adversarial network for activity recognition. To fully take advantage of the latent information in low-resolution images, a powerful network module is employed to super-resolve the extremely low-resolution images with a large scale factor. Then, a general activity recognition network is applied to analyze the super-resolved video clips. Extensive experiments on two public benchmarks were conducted to evaluate the effectiveness of our proposed method. The results demonstrate that our method outperforms several state-of-the-art low-resolution activity recognition approaches.


Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1689
Author(s):  
Eduardo J. Fernandez ◽  
Bruce Upchurch ◽  
Nancy C. Hawkes

The past two decades have seen increased interest in studies examining the welfare of elephants and animal–visitor interactions. One understudied area for both pursuits is the impact of public feeding interactions. Our study examined the effects of public feedings on the general activity of three zoo-housed elephants. Prior to public feedings, we developed and assessed a 21-behavior ethogram split into six classes of behavior. Comparisons between the elephants demonstrated that only one of the elephants engaged in stereotypies with regularity (>30%), and that the stereotypies occurred in place of most foraging. During public feedings, we compared the general activity of each elephant independently and across both public feeding and nonpublic feeding days, as well as the general activity before, during, and after a public feeding. Public feedings increased social activity and decreased stereotypies when compared with nonpublic feeding days for two of the elephants. In addition, all three elephants showed increased foraging and decreased inactivity in the period after a public feeding session. These results demonstrate that public feedings can be a useful tool for enriching the welfare of zoo-housed elephants and are among the first sets of data to demonstrate positive welfare outcomes associated with public feedings.


2021 ◽  
Vol 5 (43) ◽  
Author(s):  
A. N. Fedorkov

The development of civil society in Ukraine requires an active political position on the part of all subjects of public relations; active creative and positive orientation of actions. The basis of this process is political activity and political participation. The problem of studying the political activity of young people - from 18 to 35 years old - is especially relevant. In this regard, it is important to highlight the socio-psychological factors of active political activity, and especially the individual psychological characteristics and psychological characteristics of the microenvironment. As an object of the article, the realities of the political and socio-cultural life of the West in the 1960s and 1970s, when these factors were manifested against the background of the general activity of the youth of the West, were summarized. It is the political activity and participation of young people in various movements and associations that have determined the configuration of political and social processes. Then came the end of the Cold War, the collapse of the USSR, and this story became a general activity of the world's youth, including the youth of Ukraine. Retrospection and historiography make it possible to assess the place of psychology, political psychology in the study of these processes. Psychological science has been enriched with such achievements that they can be used as an example of solving broader problems - as a study of the phenomenon of political and socio-cultural participation of young people in solving urgent everyday problems, especially in modern crises and challenges. Keywords: psychology, political psychology, political activity and political participation, the West in the 1960s and 1970s.


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