A resected case of focal autoimmune pancreatitis with pancreatic duct wall thickening representing periductal lymphoplasmacytic infiltrate

Author(s):  
Keita Ishii ◽  
Takeshi Hisa ◽  
Akiharu Kudo ◽  
Shozo Osera ◽  
Tomoaki Shinohara ◽  
...  
Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1005
Author(s):  
Atsushi Kanno ◽  
Eriko Ikeda ◽  
Kozue Ando ◽  
Hiroki Nagai ◽  
Tetsuro Miwata ◽  
...  

Autoimmune pancreatitis (AIP) is characterized by enlargement of the pancreas and irregular narrowing of the main pancreatic duct. It is often associated with IgG4-related sclerosing cholangitis (IgG4-SC), in which the bile duct narrows. Although characteristic irregular narrowing of the pancreatic duct caused by endoscopic retrograde cholangiopancreatography is noted in AIP, it is difficult to differentiate between localized AIP and pancreatic carcinoma based on imaging of the pancreatic duct. While stenosis of the bile duct in IgG4-SC is characterized by longer-length stenosis than in cholangiocarcinoma, differentiation based on bile duct imaging alone is challenging. Endoscopic ultrasound (EUS) can characterize hypoechoic enlargement of the pancreas or bile duct wall thickening in AIP and IgG4-SC, and diagnosis using elastography and contrast-enhanced EUS are being evaluated. The utility of EUS-guided fine needle aspiration for the histological diagnosis of AIP has been reported and is expected to improve diagnostic performance for AIP. Findings in the bile duct wall from endoscopic retrograde cholangiopancreatography followed by intraductal ultrasonography are useful in differentiating IgG4-SC from cholangiocarcinoma. Diagnoses based on endoscopic ultrasonography play a central role in the diagnosis of AIP.


2019 ◽  
Vol 58 (12) ◽  
pp. 1795-1796
Author(s):  
Shunjiro Azuma ◽  
Akira Kurita ◽  
Shujiro Yazumi

2009 ◽  
Vol 42 (5) ◽  
pp. 516-521 ◽  
Author(s):  
Hiroyasu Nishizawa ◽  
Koji Fujimoto ◽  
Kazuhiko Yamagami ◽  
Takatomo Koshiba ◽  
Naoki Koizumi ◽  
...  

2006 ◽  
Vol 27 (05) ◽  
pp. 483-486 ◽  
Author(s):  
I Grgurević ◽  
M Buljevac ◽  
M Kujundžić ◽  
M Vukelić-Marković ◽  
D Kardum ◽  
...  

2012 ◽  
Vol 75 (4) ◽  
pp. 920-922 ◽  
Author(s):  
Shinsuke Koshita ◽  
Kei Ito ◽  
Naotaka Fujita ◽  
Yutaka Noda ◽  
Go Kobayashi ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Shigeyuki Kawa ◽  
Tetsuya Ito ◽  
Takayuki Watanabe ◽  
Masahiro Maruyama ◽  
Hideaki Hamano ◽  
...  

IgG4-related disease is a new disease entity involving IgG4 in its clinical presentation and having 6 characteristic features: (1) systemic involvement; (2) solitary or multiple lesions showing diffuse or localized swelling, masses, nodules, and/or wall thickening on imaging; (3) high serum IgG4 concentration >135 mg/dL; (4) abundant infiltration of lymphoplasmacytes and IgG4-bearing plasma cells; (5) a positive response to corticosteroid therapy; and (6) complications of other IgG4-related diseases. To date, most IgG4-related diseases have been recognized as extrapancreatic lesions of autoimmune pancreatitis. This paper will discuss the utility of IgG4 as a biomarker of IgG4-related diseases, including in the diagnosis of autoimmune pancreatitis and its differentiation from pancreatic cancer, in the prediction of relapse, in the long-term follow-up of patients with autoimmune pancreatitis and normal or elevated IgG4 concentrations, and in patients with autoimmune pancreatitis and extrapancreatic lesions, as well as the role of IgG4 in the pathogenesis of IgG4-related disease.


2012 ◽  
Vol 51 (16) ◽  
pp. 2135-2140 ◽  
Author(s):  
Shuya Shimizu ◽  
Itaru Naitoh ◽  
Takahiro Nakazawa ◽  
Kazuki Hayashi ◽  
Fumihiro Okumura ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document