scholarly journals Burden of Disease of Dietary Exposure to Four Chemical Contaminants in Denmark, 2019

2022 ◽  
Author(s):  
Sofie Theresa Thomsen ◽  
Lea S. Jakobsen ◽  
Hernan G. Redondo ◽  
Malene Outzen ◽  
Sisse Fagt ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Dietary Exposure ◽  
Chemical Contaminants

scholarly journals Burden of Disease of Dietary Exposure to Four Chemical Contaminants in Denmark in 2019

2021 ◽  
Author(s):  
Sofie T. Thomsen ◽  
Lea S. Jakobsen ◽  
Hernan G. Redondo ◽  
Malene Outzen ◽  
Sisse Fagt ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Burden Of Disease ◽  
Disease Burden ◽  
Disease Incidence ◽  
Inorganic Arsenic ◽  
Dietary Exposure ◽  
Dietary Guidelines ◽  
Chemical Contaminants ◽  
Adverse Health Effects ◽  
Life Years

Abstract Exposure to chemical contaminants found in foods has been associated with diverse adverse health effects. The aim of this study was to estimate the burden of disease associated with dietary exposure to four chemicals in Denmark in 2019: lead (Pb), cadmium (Cd), methylmercury (MeHg) and inorganic arsenic (i-As). We collected national food consumption and chemical food monitoring data from Danish data bases, dose-response and severity data from the scientific literature, and disease incidence and population numbers from national statistics. We adopted a risk assessment approach to estimate disease burden, quantifying the incidence, mortality and Disability-Adjusted Life Years (DALYs) attributable to dietary exposure to the chemicals. In all models, we propagated uncertainty around the input parameters through the calculations using Monte Carlo simulation. We estimated that, among these chemicals, Pb and MeHg were responsible for the highest disease burden. MeHg led to the loss of nearly 600 healthy life years, or approximately 10 DALYs per 100,000 inhabitants. Dietary exposure to Pb was estimated to cause 383 to 1,261 DALYs, corresponding to 6.6 (lower bound) to 22 (upper bound) DALYs/100,000 per year. The foods contributing most to disease burden were fish (MeHg) and sweets, fruit, and bread and cereals (Pb). The burden attributed to dietary exposure to i-As (5 DALYs) and Cd (0.04 DALY) was substantially lower. These estimates are useful supplements to traditional risk assessment to guide food safety interventions and inform dietary guidelines for different population groups.

Burden of disease associated with dietary exposure to carcinogenic aflatoxins in Portugal using human biomonitoring approach

2020 ◽  
Vol 134 ◽  
pp. 109210 ◽  
Author(s):  
C. Martins ◽  
A. Vidal ◽  
M. De Boevre ◽  
S. De Saeger ◽  
C. Nunes ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Dietary Exposure ◽  
Human Biomonitoring

scholarly journals A framework to determine the effectiveness of dietary exposure mitigation to chemical contaminants

2014 ◽  
Vol 74 ◽  
pp. 360-371 ◽  
Author(s):  
H.J. (Ine) van der Fels-Klerx ◽  
Simon G. Edwards ◽  
Marc C. Kennedy ◽  
Sue O'Hagan ◽  
Cian O'Mahony ◽  
...  
Keyword(s):  
Dietary Exposure ◽  
Chemical Contaminants ◽  
Exposure Mitigation

Burden of disease of dietary exposure to acrylamide in Denmark

2016 ◽  
Vol 90 ◽  
pp. 151-159 ◽  
Author(s):  
Lea Sletting Jakobsen ◽  
Kit Granby ◽  
Vibeke Kildegaard Knudsen ◽  
Maarten Nauta ◽  
Sara Monteiro Pires ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Dietary Exposure

scholarly journals Dietary exposure to selected chemical contaminants in fish for the Danish population

2020 ◽  
Vol 37 (6) ◽  
pp. 1027-1039 ◽  
Author(s):  
Lene Duedahl-Olesen ◽  
Tommy L. Cederberg ◽  
Tue Christensen ◽  
Sisse Fagt ◽  
Arvid Fromberg ◽  
...  
Keyword(s):  
Dietary Exposure ◽  
Danish Population ◽  
Chemical Contaminants

Burden of disease estimates of cancer caused by dietary exposure to acrylamide: How methodological choices affect the outcome

2015 ◽  
Vol 238 (2) ◽  
pp. S115 ◽  
Author(s):  
L. Sletting Jakobsen ◽  
M. Nauta ◽  
V. Kildegaard Knudsen ◽  
S. Monteiro Pires ◽  
M. Poulsen
Keyword(s):  
Burden Of Disease ◽  
Dietary Exposure ◽  
Methodological Choices

scholarly journals Estimating the burden of disease of exposure to chemical contaminants in food in Denmark

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
L S Jakobsen ◽  
S T Thomsen ◽  
S M Pires
Keyword(s):  
Public Health ◽  
Burden Of Disease ◽  
Disease Burden ◽  
National Level ◽  
Inorganic Arsenic ◽  
Health Impact ◽  
Mitigation Strategies ◽  
Chemical Contaminants ◽  
Relative Contribution ◽  
Life Years

Abstract Background Recent global estimates have shown that dietary exposure to chemical contaminants cause over 56,000 deaths and 9 million healthy life years lost each year. However, the contribution of causative agents varies greatly between world regions and countries due to local food consumption and contamination. To prioritize public health interventions to reduce disease burden, national-level risk ranking evidence is needed. The overall aims of this project are to estimate the burden of disease (BoD) of selected chemical hazards in foods consumed in Denmark, and to identify the relative contribution of foods. Methods We identified chemicals on the basis of their presumed public health impact. The final list of chemicals was defined in agreement with the Danish Veterinary and Food Administration, and included: methylmercury, inorganic arsenic, cadmium, acrylamide, dioxin/dioxin-like PCBs and lead. We estimated BoD in terms of disability adjusted life years (DALY) in a model combining exposure assessment with dose response models to derive probabilities of health effects, taking an incidence-based approach. Data were collected from the Danish National Survey of Diet and Physical Activity, food monitoring, literature, and national statistics. Results We estimated that methylmercury, inorganic arsenic, cadmium and acrylamide lead to a BoD of 514 DALY (95% uncertainty interval: 185, 990) in 2016 (preliminary results). Estimates for lead and dioxin/dioxin-like PCBs are pending. Methylmercury exposure from fish was the greatest contributor to overall burden (478 DALY), and acrylamide from potato products the second (30 DALY). The health outcomes leading to highest burden were intellectual disability and cancer. Conclusions Our estimates will assist public health managers identifying the chemical contaminants in foods with the highest impact on public health in Denmark. Future research should focus on estimating the effect of mitigation strategies on the disease burden. Key messages We provide national quantitative evidence of the health impact of chemical exposures from foods. Information on the relative contribution of foods and population groups affected may focus mitigation.

scholarly journals Perceptions and Attitudes of Gynecologic and Pediatric Professionals Regarding Dietary Exposure to Chemical Pollutants

2020 ◽  
Vol 17 (11) ◽  
pp. 3946 ◽  
Author(s):  
Juan Pedro Arrebola ◽  
Araceli Muñoz ◽  
Silvia Ferrero ◽  
Cristina Larrea-Killinger
Keyword(s):  
Health Professionals ◽  
Social Research ◽  
Dietary Exposure ◽  
Nutritional Composition ◽  
Chemical Contaminants ◽  
Chemical Pollutants ◽  
Lack Of Information ◽  
Perceptions And Attitudes ◽  
Pregnancy And Lactation ◽  
Public Health Strategies

There is increasing concern regarding the potential implications of continuous dietary exposure to low doses of artificial chemical pollutants, particularly in critical life stages such as pregnancy and lactation. Within a wider social research, we analyzed the risk perception, discourses, and attitudes of health professionals regarding dietary exposure to artificial chemical contaminants. Data was collected by personal interviews on 35 health professionals from two Spanish regions. Although the participants’ discourses were strongly dominated by the nutritional composition and microbiological contamination, 34 expressed some concern regarding metals, and 23 regarding pesticides. Although only one participant mentioned a plasticizer (i.e., bisphenol A), we noted an underlying concern, since six professionals admitted to recommending pregnant women to somewhat avoid plastic food containers, and were aware of mother-to-child transmission and accumulation of artificial chemicals. The ubiquity of the exposure, the inability to locate the threat, and contradictory messages can all create a sense of helplessness and subsequent cognitive adjustments. Our participants also reported a lack of information, particularly on emerging pollutants. In conclusion, we found a range of valuable discourses that can aid in orienting public health strategies aimed at health professionals who have a substantial influence on their patients.

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