scholarly journals VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau

2013 ◽  
Vol 63 (3) ◽  
pp. 183-193 ◽  
Author(s):  
Norman E. Buroker ◽  
Xue-Han Ning ◽  
Zhao-Nian Zhou ◽  
Kui Li ◽  
Wei-Jun Cen ◽  
...  
Keyword(s):  
Tibetan Plateau ◽  
High Altitude ◽  
Binding Sites ◽  
Transcriptional Factor ◽  
Altitude Sickness ◽  
Factor Binding

scholarly journals Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Wen-Teng Chang ◽  
Ming-Yuan Hong ◽  
Chien-Liang Chen ◽  
Chi-Yuan Hwang ◽  
Cheng-Chieh Tsai ◽  
...  
Keyword(s):  
Binding Sites ◽  
Inflammatory Diseases ◽  
Inducible Promoter ◽  
Transcriptional Factor ◽  
Factor Binding ◽  
Inflammatory Processes ◽  
Nuclear Receptor Family ◽  
Specificity Protein ◽  
Receptor Family ◽  
Pro Inflammatory Cytokines

Abstract Background Glucocorticoids (GCs) have been extensively used as essential modulators in clinical infectious and inflammatory diseases. The GC receptor (GR) is a transcription factor belonging to the nuclear receptor family that regulates anti-inflammatory processes and releases pro-inflammatory cytokines, such as interleukin (IL)-6. Results Five putative GR binding sites and other transcriptional factor binding sites were identified on theIL-6 promoter, and dexamethasone (DEX) was noted to reduce the lipopolysaccharide (LPS)-induced IL-6 production. Among mutant transcriptional factor binding sites, nuclear factor-kappa B (NF-κB), activator protein (AP)-1, and specificity protein (Sp)1–2 sites reduced basal and LPS-induced IL-6 promoter activities through various responses. The second GR binding site (GR2) was noted to play a crucial role in both basal and inducible promoter activities in LPS-induced inflammation. Conclusions We concluded that selective GR2 modulator might exert agonistic and antagonistic effects and could activate crucial signaling pathways during the LPS-stimulated inflammatory process.

EPAS1 and EGLN1 associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai–Tibetan Plateau

2012 ◽  
Vol 49 (2) ◽  
pp. 67-73 ◽  
Author(s):  
Norman E. Buroker ◽  
Xue-Han Ning ◽  
Zhao-Nian Zhou ◽  
Kui Li ◽  
Wei-Jun Cen ◽  
...  
Keyword(s):  
Tibetan Plateau ◽  
High Altitude ◽  
Altitude Sickness

Sequence Characterization of S100A8 Gene Reveals Structural Differences of Protein and Transcriptional Factor Binding Sites in Water Buffalo and Yak

2011 ◽  
Vol 22 (3) ◽  
pp. 124-132
Author(s):  
P. Kathiravan ◽  
S. Goyal ◽  
R. S. Kataria ◽  
B. P. Mishra ◽  
S. Jayakumar ◽  
...  
Keyword(s):  
Binding Sites ◽  
Water Buffalo ◽  
Transcriptional Factor ◽  
Sequence Characterization ◽  
Factor Binding ◽  
Structural Differences

scholarly journals VEGFA rSNPs, transcriptional factor binding sites and human disease

2013 ◽  
Vol 64 (1) ◽  
pp. 73-76 ◽  
Author(s):  
Norman E. Buroker
Keyword(s):  
Binding Sites ◽  
Human Disease ◽  
Transcriptional Factor ◽  
Factor Binding

scholarly journals SNPs, transcriptional factor binding sites and disease

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Norman E. Buroker
Keyword(s):  
Binding Sites ◽  
Transcriptional Factor ◽  
Factor Binding
Sign in / Sign up

Export Citation Format

Share Document