Prediction of Aromatic Hydroxylation Sites for Human CYP1A2 Substrates Using Condensed Graph of Reactions

2018 ◽  
Vol 8 (1) ◽  
pp. 384-389 ◽  
Author(s):  
T. I. Madzhidov ◽  
A. A. Khakimova ◽  
R. I. Nugmanov ◽  
C. Muller ◽  
G. Marcou ◽  
...  
Keyword(s):  
Aromatic Hydroxylation ◽  
Human Cyp1a2

Unmasking Steps in Intramolecular Aromatic Hydroxylation by a Synthetic Nonheme Oxoiron(IV) Complex

2021 ◽  
Author(s):  
Lawrence Que ◽  
Yuan Sheng ◽  
Chase S. Abelson ◽  
Jai Prakash ◽  
Apparao Draksharapu ◽  
...  
Keyword(s):  
Aromatic Hydroxylation

scholarly journals Aromatic Hydroxylation of Indan by o-Xylene-Degrading Rhodococcus sp. Strain DK17

2009 ◽  
Vol 76 (1) ◽  
pp. 375-377 ◽  
Author(s):  
Dockyu Kim ◽  
Choong Hwan Lee ◽  
Jung Nam Choi ◽  
Ki Young Choi ◽  
Gerben J. Zylstra ◽  
...  
Keyword(s):  
Reverse Transcription ◽  
Ring Cleavage ◽  
Growth Substrate ◽  
Aromatic Moiety ◽  
Reverse Transcription Pcr ◽  
Aromatic Hydroxylation ◽  
Rhodococcus Sp

ABSTRACT The metabolically versatile Rhodococcus sp. strain DK17 utilizes indan as a growth substrate via the o-xylene pathway. Metabolite and reverse transcription-PCR analyses indicate that o-xylene dioxygenase hydroxylates indan at the 4,5 position of the aromatic moiety to form cis-indan-4,5-dihydrodiol, which is dehydrogenated to 4,5-indandiol by a dehydrogenase. 4,5-Indandiol undergoes ring cleavage by a meta-cleavage dioxygenase.

scholarly journals Inhibitory effects of antiarrhythmic drugs on phenacetin O‐deethylation catalysed by human CYP1A2

1998 ◽  
Vol 45 (4) ◽  
pp. 361-368 ◽  
Author(s):  
K. Kobayashi ◽  
M. Nakajima ◽  
K. Chiba ◽  
T. Yamamoto ◽  
M. Tani ◽  
...  
Keyword(s):  
Antiarrhythmic Drugs ◽  
Inhibitory Effects ◽  
Human Cyp1a2

scholarly journals Identification of a pro-inhibitory region on the surface of human CYP1A2

1995 ◽  
Vol 78 ◽  
pp. 16
Author(s):  
D.A. Adams ◽  
R.J. Edwards ◽  
A.R. Boobis
Keyword(s):  
Inhibitory Region ◽  
Human Cyp1a2

Mechanistic Insight into the Aromatic Hydroxylation by High-Valent Iron(IV)-oxo Porphyrin π-Cation Radical Complexes

2007 ◽  
Vol 72 (16) ◽  
pp. 6301-6304 ◽  
Author(s):  
Min-Jung Kang ◽  
Woon Ju Song ◽  
Ah-Rim Han ◽  
Young S. Choi ◽  
Ho G. Jang ◽  
...  
Keyword(s):  
Cation Radical ◽  
Mechanistic Insight ◽  
Aromatic Hydroxylation ◽  
High Valent ◽  
Insight Into

Different Geometric Requirements for Cytochrome P450-Catalyzed Aliphatic Versus Aromatic Hydroxylation Results in Chemoselective Oxidation

ACS Catalysis ◽  
2022 ◽  
pp. 1258-1267
Author(s):  
Tom Coleman ◽  
Alicia M. Kirk ◽  
Joel H. Z. Lee ◽  
Daniel Z. Doherty ◽  
John B. Bruning ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Aromatic Hydroxylation

Synthesis of (NHC)Pd(salicylaldimine)Cl complexes through template-directed ortho-aromatic metaloxylation of NHC–palladacycles derived from arylimines

2017 ◽  
Vol 46 (15) ◽  
pp. 5003-5007 ◽  
Author(s):  
Jin Yang
Keyword(s):  
Butyl Hydroperoxide ◽  
Catalytic Activities ◽  
Aromatic Hydroxylation

NHC–palladacycles were ortho-aromatic metaloxylated in the presence of tert-butyl hydroperoxide, affording (NHC)Pd(salicylaldimine)Cl complexes. Furthermore, they also showed efficient catalytic activities toward the ortho-aromatic hydroxylation of arylimines.

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