Mindful Non-judging and Experiential Avoidance Before Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) are Associated to Post-traumatic Stress Disorder (PTSD) Symptomatology 5 Months Later

Mindfulness ◽  
2021 ◽  
Author(s):  
Maya Corman ◽  
Marie-Thérèse Rubio ◽  
Aurélie Cabrespine ◽  
Isabelle Brindel ◽  
Jacques-Olivier Bay ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Experiential Avoidance ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Hematopoietic Stem ◽  
Post Traumatic ◽  
Ptsd Symptomatology

Quality of life and depression during hospitalization for hematopoietic stem cell transplantation to predict quality of life and post-traumatic stress disorder symptoms at 6 months post-transplant.

2015 ◽  
Vol 33 (29_suppl) ◽  
pp. 215-215
Author(s):  
Areej El-Jawahri ◽  
Harry VanDusen ◽  
Lara Traeger ◽  
Joel Fishbein ◽  
Tanya Keenan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Stem Cell ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Ptsd Symptoms ◽  
Post Traumatic Stress ◽  
Post Traumatic

215 Background: Patients undergoinghematopoietic stem cell transplantation (HCT) experience a steep deterioration in quality of life (QOL) and mood during hospitalization for HCT. The impact of this deterioration on patients’ long-term QOL and post-traumatic stress disorder (PTSD) symptoms is unknown. Methods: We conducted a prospective longitudinal study of patients hospitalized for HCT. At baseline (day-6), day+1, day+8, and 6 months post-HCT, we assessed QOL (Functional Assessment of Cancer Therapy-Bone Marrow Transplantation [FACT-BMT]) and mood (Hospital Anxiety and Depression Scale [HADS]). We used the PTSD Checklist to assess for PTSD symptoms at 6 months. We used multivariable linear regression models to identify predictors of QOL and PTSD symptoms at 6 months post-HCT. Results: We enrolled 97% (90/93) of consecutively eligible patients undergoing autologous (n = 30), myeloablative allogeneic (n = 30), or reduced intensity allogeneic (n = 30) HCT. Overall, patients’ QOL at 6 months (mean FACT-BMT: 110, 95%CI [104-116]) recovered to baseline pre-transplant values (mean FACT-BMT: 110, 95% CI [107-115]). At 6 months, 28.4% of participants met provisional diagnostic criteria for PTSD, and 43.3% had clinically significant depression. In multivariable regression analyses adjusting for baseline QOL, mood, other covariates, change in QOL and depression scores during hospitalization for HCT predicted impaired QOL (DQOL β = 1.13, P < 0.0001, D HADS-depression β = 2.51, P = 0.001) and PTSD symptoms (DQOL β = 0.50, P < 0.0001, DHADS-depression β = 1.22, P < 0.0001) at 6 months post-HCT. Conclusions: While patients’ overall QOL at 6 months post-HCT returned to baseline values, a significant proportion met provisional diagnostic criteria for PTSD and depression. The decline in QOL and increase in depressive symptoms during hospitalization for HCT were the most important predictors of long-term QOL impairment and PTSD symptoms. Future studies should evaluate whether interventions to improve QOL and reduce psychological distress during HCT may improve long-term QOL and reduce the risk of PTSD symptoms.

scholarly journals Stem Cell Therapy for Post-Traumatic Stress Disorder: A Novel Therapeutic Approach

Diseases ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 77
Author(s):  
Dhir Gala ◽  
Vikram Gurusamy ◽  
Krishna Patel ◽  
Sreedevi Damodar ◽  
Girish Swaminath ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Glutamate Excitotoxicity ◽  
Post Traumatic Stress ◽  
Post Traumatic

Stem cell therapy is a rapidly evolving field of regenerative medicine being employed for the management of various central nervous system disorders. The ability to self-renew, differentiate into specialized cells, and integrate into neuronal networks has positioned stem cells as an ideal mechanism for the treatment of epilepsy. Epilepsy is characterized by repetitive seizures caused by imbalance in the GABA and glutamate neurotransmission following neuronal damage. Stem cells provide benefit by reducing the glutamate excitotoxicity and strengthening the GABAergic inter-neuron connections. Similar to the abnormal neuroanatomic location in epilepsy, post-traumatic stress disorder (PTSD) is caused by hyperarousal in the amygdala and decreased activity of the hippocampus and medial prefrontal cortex. Thus, stem cells could be used to modulate neuronal interconnectivity. In this review, we provide a rationale for the use of stem cell therapy in the treatment of PTSD.

Post-traumatic stress disorder in women who were victims of childhood sexual abuse

1991 ◽  
Vol 8 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Kevin O'Neill ◽  
Kamal Gupta
Keyword(s):  
Sexual Abuse ◽  
Psychiatric Disorder ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Sexually Abused ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Structured Interviews ◽  
Post Traumatic ◽  
Ptsd Symptomatology

AbstractTwenty-six women who had been sexually abused in childhood were assessed by means of structured interviews as to the nature of the abusive experience and subsequent psychiatric disorder. Nineteen (73.1%) fulfilled the criteria of Post Traumatic Stress Disorder and a comparison was made between PTSD and non-PTSD groups with regard to quantitative abuse variables. The phenomenon of latency or delay in onset in PTSD symptomatology was investigated. The possible implications of those findings were discussed.

Post-Traumatic Stress Disorder Symptomatology in People affected by Home Eviction in Spain

2017 ◽  
Vol 20 ◽  
Author(s):  
Humbelina Robles-Ortega ◽  
Pedro Guerra ◽  
Isis González-Usera ◽  
José Luis Mata-Martín ◽  
M. Carmen Fernández-Santaella ◽  
...  
Keyword(s):  
Mental Health ◽  
Perceived Stress ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Mental Health Problems ◽  
Structured Interview ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Ptsd Symptomatology

AbstractDespite the higher proportion of foreclosures and home evictions executed in Spain, compared to other countries, and the known link between social exclusion and mental health problems, studies exploring this association in Spain remain scarce. This study investigated the link between the process of home eviction and the appearance of symptomatology of post-traumatic stress disorder (PTSD), anxiety, depression, and perceived stress. Two hundred and five people affected by the process of home eviction were assessed using a structured interview that included three validated assessment instruments for PTSD, perceived stress, anxiety and depression. Analysis involved comparison with the normative groups that formed the validation studies together with regression analysis to determine the major psychological and socio-demographic predictors of perceived stress. Of the participants, 95.1% reported that they were experiencing the process of home eviction with fear, helplessness, or horror. In PTSD symptomatology, they scored higher than the normative PTSD group in symptoms of avoidance (t = 5.01; p < .05), activation (t = 5.48; p < .01), and total score (t = 4.15; p < .05). Of this subgroup, 72.5% fulfilled the DSM-IV symptom criteria for PTSD. The major predictor of perceived stress was PTSD symptomatology (B = .09; p < .001). The process of home eviction in Spain is having an alarming impact on mental health of affected people calling for effective measures to provide psychological and social support.

Experiential Avoidance and Post-Traumatic Stress Disorder

2001 ◽  
Vol 4 (2) ◽  
pp. 211-245 ◽  
Author(s):  
Laura E. Boeschen ◽  
Mary P. Koss ◽  
Aurelio Jose Figueredo ◽  
James A. Coan
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Experiential Avoidance ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic
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