Semi-Automatic Reconstruction of Patient-Specific Stented Coronaries based on Data Assimilation and Computer Aided Design

2022 ◽  
Author(s):  
Adrien Lefieux ◽  
Sara Bridio ◽  
David Molony ◽  
Marina Piccinelli ◽  
Claudio Chiastra ◽  
...  
Keyword(s):  
Data Assimilation ◽  
Computer Aided Design ◽  
Patient Specific ◽  
Computer Aided ◽  
Aided Design

scholarly journals Patient-Specific Coronary Artery 3D Printing Based on Intravascular Optical Coherence Tomography and Coronary Angiography

Complexity ◽  
2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Chenxi Huang ◽  
Yisha Lan ◽  
Sirui Chen ◽  
Qing Liu ◽  
Xin Luo ◽  
...  
Keyword(s):  
Coronary Artery ◽  
3D Printing ◽  
Coronary Angiography ◽  
Coronary Arteries ◽  
Computer Aided Design ◽  
Patient Specific ◽  
3D Printing Technology ◽  
Vessel Lumen ◽  
Computer Aided ◽  
Aided Design

Despite the new ideas were inspired in medical treatment by the rapid advancement of three-dimensional (3D) printing technology, there is still rare research work reported on 3D printing of coronary arteries being documented in the literature. In this work, the application value of 3D printing technology in the treatment of cardiovascular diseases has been explored via comparison study between the 3D printed vascular solid model and the computer aided design (CAD) model. In this paper, a new framework is proposed to achieve a 3D printing vascular model with high simulation. The patient-specific 3D reconstruction of the coronary arteries is performed by the detailed morphological information abstracted from the contour of the vessel lumen. In the process of reconstruction which has 5 steps, the morphological details of the contour view of the vessel lumen are merged along with the curvature and length information provided by the coronary angiography. After comparing with the diameter of the narrow section and the diameter of the normal section in CAD models and 3D printing model, it can be concluded that there is a high correlation between the diameter of vascular stenosis measured in 3D printing models and computer aided design models. The 3D printing model has high-modeling ability and high precision, which can represent the original coronary artery appearance accurately. It can be adapted for prevascularization planning to support doctors in determining the surgical procedures.

Optimal Sensor Design Using Patient-Specific Images

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
Sukhi Basati ◽  
Timothy J. Harris ◽  
Andreas A. Linninger
Keyword(s):  
Computer Aided Design ◽  
Rational Design ◽  
Treatment Options ◽  
Patient Specific ◽  
Data Sets ◽  
Disease States ◽  
Magnetic Resonance Data ◽  
Computer Aided ◽  
Aided Design ◽  
Pathological Disease

In diseases such as hydrocephalus, the cerebral ventricles enlarge. The treatment options for these patients are presently based on pressure, which has limited capabilities. We present the design of a volume sensor as an alternative monitoring option. Through the use of computer aided design and simulation, we optimized a sensor in silico with fewer resources. Specifically, we designed a sensor for animal experimentation with a scalable procedure for human sensors. In this paper, we present a rational design approach for a sensor that integrates advances in medical imaging. Magnetic resonance data sets of both normal and diseased subjects were used as a virtual laboratory. Finite element simulations were performed under pathological disease states of the brain as a contribution toward an accelerated device design. An optimized sensor was then fabricated for these subjects based on the outcome of the simulations. In this paper, we explain how a computer aided subject-specific design was used to help fabricate and test our sensor.

scholarly journals Computer-Assisted Mandibular Reconstruction using a Patient-Specific Reconstruction Plate Fabricated with Computer-Aided Design and Manufacturing Techniques

2014 ◽  
Vol 7 (2) ◽  
pp. 158-166 ◽  
Author(s):  
Frank Wilde ◽  
Carl-Peter Cornelius ◽  
Alexander Schramm
Keyword(s):  
Computer Aided Design ◽  
Mandibular Reconstruction ◽  
Patient Specific ◽  
Computer Assisted ◽  
Reconstruction Plate ◽  
Fibula Flap ◽  
Computer Aided ◽  
Cad Cam ◽  
Aided Design ◽  
Five Axis

We investigated the workflow of computer-assisted mandibular reconstruction that was performed with a patient-specific mandibular reconstruction plate fabricated with computer-aided design and computer-aided manufacturing (CAD/CAM) techniques and a fibula flap. We assessed the feasibility of this technique from virtual planning to the completion of surgery. Computed tomography (CT) scans of a cadaveric skull and fibula were obtained for the virtual simulation of mandibular resection and reconstruction using ProPlan CMF software (Materialise®/DePuy Synthes®). The virtual model of the reconstructed mandible provided the basis for the computer-aided design of a patient-specific reconstruction plate that was milled from titanium using a five-axis milling machine and CAM techniques. CAD/CAM techniques were used for producing resection guides for mandibular resection and cutting guides for harvesting a fibula flap. Mandibular reconstruction was simulated in a cadaveric wet laboratory. No problems were encountered during the procedure. The plate was fixed accurately to the residual bone without difficulty. The fibula segments were attached to the plate rapidly and reliably. The fusion of preoperative and postoperative CT datasets demonstrated high reconstruction precision. Computer-assisted mandibular reconstruction with CAD/CAM-fabricated patient-specific reconstruction plates appears to be a promising approach for mandibular reconstruction. Clinical trials are required to determine whether these promising results can be translated into successful practice and what further developments are needed.

scholarly journals Evolution of design considerations in complex craniofacial reconstruction using patient-specific implants

2016 ◽  
Vol 231 (6) ◽  
pp. 509-524 ◽  
Author(s):  
Sean Peel ◽  
Satyajeet Bhatia ◽  
Dominic Eggbeer ◽  
Daniel S Morris ◽  
Caroline Hayhurst
Keyword(s):  
Additive Manufacturing ◽  
Case Studies ◽  
Computer Aided Design ◽  
Titanium Implants ◽  
Patient Specific ◽  
Patient Case ◽  
Computer Aided Manufacturing ◽  
Design Considerations ◽  
Computer Aided ◽  
Aided Design

Previously published evidence has established major clinical benefits from using computer-aided design, computer-aided manufacturing, and additive manufacturing to produce patient-specific devices. These include cutting guides, drilling guides, positioning guides, and implants. However, custom devices produced using these methods are still not in routine use, particularly by the UK National Health Service. Oft-cited reasons for this slow uptake include the following: a higher up-front cost than conventionally fabricated devices, material-choice uncertainty, and a lack of long-term follow-up due to their relatively recent introduction. This article identifies a further gap in current knowledge – that of design rules, or key specification considerations for complex computer-aided design/computer-aided manufacturing/additive manufacturing devices. This research begins to address the gap by combining a detailed review of the literature with first-hand experience of interdisciplinary collaboration on five craniofacial patient case studies. In each patient case, bony lesions in the orbito-temporal region were segmented, excised, and reconstructed in the virtual environment. Three cases translated these digital plans into theatre via polymer surgical guides. Four cases utilised additive manufacturing to fabricate titanium implants. One implant was machined from polyether ether ketone. From the literature, articles with relevant abstracts were analysed to extract design considerations. In all, 19 frequently recurring design considerations were extracted from previous publications. Nine new design considerations were extracted from the case studies – on the basis of subjective clinical evaluation. These were synthesised to produce a design considerations framework to assist clinicians with prescribing and design engineers with modelling. Promising avenues for further research are proposed.

scholarly journals Additively manufactured versus conventionally pressed cranioplasty implants: An accuracy comparison

2018 ◽  
Vol 232 (9) ◽  
pp. 949-961 ◽  
Author(s):  
Sean Peel ◽  
Dominic Eggbeer ◽  
Hanna Burton ◽  
Hayley Hanson ◽  
Peter L Evans
Keyword(s):  
Additive Manufacturing ◽  
Computer Aided Design ◽  
Best Practice ◽  
Patient Specific ◽  
Computer Aided ◽  
Design Software ◽  
Uk National Health Service ◽  
Similar Accuracy ◽  
The Uk ◽  
Aided Design

This article compared the accuracy of producing patient-specific cranioplasty implants using four different approaches. Benchmark geometry was designed to represent a cranium and a defect added simulating a craniectomy. An ‘ideal’ contour reconstruction was calculated and compared against reconstructions resulting from the four approaches –‘conventional’, ‘semi-digital’, ‘digital – non-automated’ and ‘digital – semi-automated’. The ‘conventional’ approach relied on hand carving a reconstruction, turning this into a press tool, and pressing titanium sheet. This approach is common in the UK National Health Service. The ‘semi-digital’ approach removed the hand-carving element. Both of the ‘digital’ approaches utilised additive manufacturing to produce the end-use implant. The geometries were designed using a non-specialised computer-aided design software and a semi-automated cranioplasty implant-specific computer-aided design software. It was found that all plates were clinically acceptable and that the digitally designed and additive manufacturing plates were as accurate as the conventional implants. There were no significant differences between the additive manufacturing plates designed using non-specialised computer-aided design software and those designed using the semi-automated tool. The semi-automated software and additive manufacturing production process were capable of producing cranioplasty implants of similar accuracy to multi-purpose software and additive manufacturing, and both were more accurate than handmade implants. The difference was not of clinical significance, demonstrating that the accuracy of additive manufacturing cranioplasty implants meets current best practice.

scholarly journals Three-dimensional printing of a patient-specific engineered nasal cartilage for augmentative rhinoplasty

2019 ◽  
Vol 10 ◽  
pp. 204173141882479 ◽  
Author(s):  
Hee-Gyeong Yi ◽  
Yeong-Jin Choi ◽  
Jin Woo Jung ◽  
Jinah Jang ◽  
Tae-Ha Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Computer Aided Design ◽  
Three Dimensional ◽  
Patient Specific ◽  
Adipose Derived Stem Cells ◽  
Three Dimensional Printing ◽  
Nasal Cartilage ◽  
Computer Aided ◽  
Aided Design ◽  
Dimensional Printing

Autologous cartilages or synthetic nasal implants have been utilized in augmentative rhinoplasty to reconstruct the nasal shape for therapeutic and cosmetic purposes. Autologous cartilage is considered to be an ideal graft, but has drawbacks, such as limited cartilage source, requirements of additional surgery for obtaining autologous cartilage, and donor site morbidity. In contrast, synthetic nasal implants are abundantly available but have low biocompatibility than the autologous cartilages. Moreover, the currently used nasal cartilage grafts involve additional reshaping processes, by meticulous manual carving during surgery to fit the diverse nose shape of each patient. The final shapes of the manually tailored implants are highly dependent on the surgeons’ proficiency and often result in patient dissatisfaction and even undesired separation of the implant. This study describes a new process of rhinoplasty, which integrates three-dimensional printing and tissue engineering approaches. We established a serial procedure based on computer-aided design to generate a three-dimensional model of customized nasal implant, and the model was fabricated through three-dimensional printing. An engineered nasal cartilage implant was generated by injecting cartilage-derived hydrogel containing human adipose-derived stem cells into the implant containing the octahedral interior architecture. We observed remarkable expression levels of chondrogenic markers from the human adipose-derived stem cells grown in the engineered nasal cartilage with the cartilage-derived hydrogel. In addition, the engineered nasal cartilage, which was implanted into mouse subcutaneous region, exhibited maintenance of the exquisite shape and structure, and striking formation of the cartilaginous tissues for 12 weeks. We expect that the developed process, which combines computer-aided design, three-dimensional printing, and tissue-derived hydrogel, would be beneficial in generating implants of other types of tissue.

scholarly journals Design and manufacturing of patient-specific orthodontic appliances by computer-aided engineering techniques

2017 ◽  
Vol 232 (1) ◽  
pp. 54-66 ◽  
Author(s):  
Sandro Barone ◽  
Paolo Neri ◽  
Alessandro Paoli ◽  
Armando Viviano Razionale
Keyword(s):  
Computer Aided Design ◽  
Low Cost ◽  
Element Model ◽  
Patient Specific ◽  
Orthodontic Appliances ◽  
Digital Reconstruction ◽  
Computer Aided ◽  
Design And Manufacturing ◽  
Aided Design ◽  
Low Cost Manufacturing

Orthodontic treatments are usually performed using fixed brackets or removable oral appliances, which are traditionally made from alginate impressions and wax registrations. Among removable devices, eruption guidance appliances are used for early orthodontic treatments in order to intercept and prevent malocclusion problems. Commercially available eruption guidance appliances, however, are symmetric devices produced using a few standard sizes. For this reason, they are not able to meet all the specific patient’s needs since the actual dental anatomies present various geometries and asymmetric conditions. In this article, a computer-aided design-based methodology for the design and manufacturing of a patient-specific eruption guidance appliances is presented. The proposed approach is based on the digitalization of several steps of the overall process: from the digital reconstruction of patients’ anatomies to the manufacturing of customized appliances. A finite element model has been developed to evaluate the temporomandibular joint disks stress level caused by using symmetric eruption guidance appliances with different teeth misalignment conditions. The developed model can then be used to guide the design of a patient-specific appliance with the aim at reducing the patient discomfort. At this purpose, two different customization levels are proposed in order to face both arches and single tooth misalignment issues. A low-cost manufacturing process, based on an additive manufacturing technique, is finally presented and discussed.

Computer Aided Design of Implant Based Dental Restorations

2008 ◽  
Author(s):  
Ming C. Leu ◽  
Amit Gawate
Keyword(s):  
Computer Aided Design ◽  
Patient Specific ◽  
Facial Features ◽  
Cad Model ◽  
Dental Restorations ◽  
Computer Aided ◽  
Cad Cam ◽  
Scan Data ◽  
Aided Design ◽  
Cam Systems

Implant based dental restorations have many advantages over standard removable dentures because using implants can prevent the loss of jawbones, help restore facial features, and enable the patients to get firm bites. A critical step in this kind of restorations is the fabrication of the dental bar on which the denture sits. A dental bar is patient-specific because each patient’s jawbone is unique and the device needs to be conforming to the patient’s gingival surface. The design of a dental bar is crucial to the success of dental restorations. Traditionally, designing a dental bar is a lengthy and laborious process and requires high levels of craftsmanship. There have been attempts to develop CAD/CAM systems towards automating design and fabrication of dental restorations. However, currently available commercial CAD/CAM systems are only capable of making crowns, bridges, copings, onlays and veneers, and they are not capable of making dental restorations involving multiple teeth. The present paper describes a method for computer aided design of a dental bar used in implant based dental restorations. The method starts with a set of digital scan data representing the patient’s gingival surface and generates a CAD model of a dental bar that is ready for fabrication of a physical dental bar.

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