Dosimetric characteristics of a thin bolus made of variable shape tungsten rubber for photon radiotherapy

Author(s):  
Katsuya Okuhata ◽  
Mikoto Tamura ◽  
Hajime Monzen ◽  
Yasumasa Nishimura
2021 ◽  
Author(s):  
Katsuya Okuhata ◽  
Hajime Monzen ◽  
Mikoto Tamura ◽  
Yasumasa Nishimura

Abstract In this study, we aim to clarify the dosimetric characteristics of a real time variable shape rubber containing tungsten (STR) as a thin bolus in 6-MV photon radiotherapy. The percentage depth doses (PDDs) and lateral dose profiles (irradiation field = 10 × 10 cm2) in the water-equivalent phantom were measured and compared between no bolus, a conventional 5-mm gel bolus, and 1-, 2-, and 3-mm STR boluses. The characteristics of the PDDs were evaluated according to relative doses at 1 mm depth (D1mm) and depth of maximum dose (dmax). The water-equivalent thicknesses of the STR boluses were determined by shifting the distance of the PDD’s build-up curve until it overlaid that with no bolus. The penumbra size and width of the 50% dose were evaluated using lateral dose profiles. The D1mm with no bolus, 5-mm gel bolus, and 1-, 2-, and 3-mm STR boluses were 47.6%, 91.5%, 86.6%, 89.3%, and 89.4%, respectively, and the respective dmax values were 15, 10, 12, 11, and 10 mm. The water-equivalent thicknesses of the 1-, 2-, and 3-mm STR boluses were 4.4, 4.9, and 5.1 mm, respectively. There were no differences for those in lateral dose profiles. The 1-mm-thick STR thin bolus shifted the depth dose profile by 4.4 mm and could be used as a customized bolus for photon radiotherapy.


2021 ◽  
pp. 1-8
Author(s):  
Maryam Moteabbed ◽  
Mukesh Harisinghani ◽  
Harald Paganetti ◽  
Alexei Trofimov ◽  
Hsiao-Ming Lu ◽  
...  

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii431-iii431
Author(s):  
Lisa Kahalley ◽  
Rachel Peterson ◽  
M Douglas Ris ◽  
Laura Janzen ◽  
M Fatih Okcu ◽  
...  

Abstract PURPOSE By reducing dose to normal brain tissue, proton radiotherapy (PRT) may lessen neurocognitive risk traditionally associated with photon radiotherapy (XRT). We examined change in neurocognitive scores over time in pediatric medulloblastoma patients treated with PRT versus XRT. METHODS Neurocognitive scores from 79 patients (37 PRT, 42 XRT) were examined. Patients were treated between 2007–2018 on the same treatment protocols that differed only by craniospinal modality (PRT versus XRT). Change in scores over time since diagnosis were compared between groups. RESULTS Groups were similar on most demographic/clinical variables: sex (67.1% male), age at diagnosis (mean 8.6 years), CSI dose (median 23.4 Gy), length of follow-up (mean 4.3 years), and parental education (mean 14.3 years). Boost dose (p<0.001) and margin (p=0.001) differed between groups. Adjusting for covariates, the PRT group exhibited superior outcomes in global IQ, perceptual reasoning, and working memory versus the XRT group (all p<0.05). The XRT group exhibited significant decline in global IQ, working memory, and processing speed (all p<0.05). The PRT group exhibited stable scores in all domains except processing speed (p=0.003). Posterior fossa syndrome imparted risk independent of modality. CONCLUSION This is the first study comparing neurocognitive trajectories between pediatric patients treated for medulloblastoma with PRT versus XRT on comparable, contemporary protocols. PRT was associated with more favorable neurocognitive outcomes in most domains compared to XRT, although processing speed emerged as vulnerable in both groups. This is the strongest evidence to date of an intellectual sparing advantage with PRT in the treatment of pediatric medulloblastoma.


Author(s):  
Nicolas Loizeau ◽  
Silvia Fabiano ◽  
Dávid Papp ◽  
Kristin Stützer ◽  
Annika Jakobi ◽  
...  

1999 ◽  
Vol 175 (S2) ◽  
pp. 99-101 ◽  
Author(s):  
Gerda Hohenberg ◽  
Felix Sedlmayer
Keyword(s):  

1998 ◽  
Vol 81 (21) ◽  
pp. 4632-4635 ◽  
Author(s):  
Nail Akhmediev ◽  
Wiesław Królikowski ◽  
A. W. Snyder

Author(s):  
Benjamin C. Mac Murray ◽  
Bryan N. Peele ◽  
Patricia Xu ◽  
Josef Spjut ◽  
Omer Shapira ◽  
...  

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