Assessment of DNA damage caused by locally produced hydroxyapatite-silica nanocomposite using Comet assay on human lung fibroblast cell line

2012 ◽  
Vol 8 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Marahaini Musa ◽  
Thirumulu Ponnuraj Kannan ◽  
Sam’an Malik Masudi ◽  
Ismail Ab Rahman
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Cell Line ◽  
Human Lung ◽  
Fibroblast Cell ◽  
Lung Fibroblast ◽  
Fibroblast Cell Line ◽  
Human Lung Fibroblast ◽  
Lung Fibroblast Cell Line ◽  
Silica Nanocomposite

Histamine and Serotonin Stimulate Eotaxin Production by a Human Lung Fibroblast Cell Line

2002 ◽  
Vol 128 (Suppl. 1) ◽  
pp. 12-17 ◽  
Author(s):  
Etsuro Sato ◽  
Masayuki Haniuda ◽  
Hiroki Numanami ◽  
Toshiki Ushiyama ◽  
Akihiro Tsukadaira ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Lung ◽  
Fibroblast Cell ◽  
Lung Fibroblast ◽  
Fibroblast Cell Line ◽  
Human Lung Fibroblast ◽  
Lung Fibroblast Cell Line

Bradykinin stimulates eotaxin production by a human lung fibroblast cell line

2000 ◽  
Vol 106 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Etsuro Sato ◽  
Dan K. Nelson ◽  
Sekiya Koyama ◽  
Jeffrey C. Hoyt ◽  
Richard A. Robbins
Keyword(s):  
Cell Line ◽  
Human Lung ◽  
Fibroblast Cell ◽  
Lung Fibroblast ◽  
Fibroblast Cell Line ◽  
Human Lung Fibroblast ◽  
Lung Fibroblast Cell Line

scholarly journals Enhancement human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8.

1994 ◽  
Vol 68 (11) ◽  
pp. 7582-7585 ◽  
Author(s):  
T Murayama ◽  
K Kuno ◽  
F Jisaki ◽  
M Obuchi ◽  
D Sakamuro ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Cytomegalovirus ◽  
Human Lung ◽  
Fibroblast Cell ◽  
Lung Fibroblast ◽  
Interleukin 8 ◽  
Fibroblast Cell Line ◽  
Human Lung Fibroblast ◽  
Lung Fibroblast Cell Line

scholarly journals Essential Oil Content of the Rhizome ofCurcuma purpurascensBl. (Temu Tis) and Its Antiproliferative Effect on Selected Human Carcinoma Cell Lines

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sok-Lai Hong ◽  
Guan-Serm Lee ◽  
Syarifah Nur Syed Abdul Rahman ◽  
Omer Abdalla Ahmed Hamdi ◽  
Khalijah Awang ◽  
...  
Keyword(s):  
Human Lung ◽  
Carcinoma Cell ◽  
Fibroblast Cell ◽  
Lung Fibroblast ◽  
Fibroblast Cell Line ◽  
Human Carcinoma ◽  
Human Lung Fibroblast ◽  
Carcinoma Cell Lines ◽  
Lung Fibroblast Cell Line ◽  
Human Carcinoma Cell

Curcuma purpurascensBl., belonging to the Zingiberaceae family, is known astemu tisin Yogyakarta, Indonesia. In this study, the hydrodistilled dried ground rhizome oil was investigated for its chemical content and antiproliferative activity against selected human carcinoma cell lines (MCF7, Ca Ski, A549, HT29, and HCT116) and a normal human lung fibroblast cell line (MRC5). Results from GC-MS and GC-FID analysis of the rhizome oil oftemu tisshowed turmerone as the major component, followed by germacrone,ar-turmerone, germacrene-B, and curlone. The rhizome oil oftemu tisexhibited strong cytotoxicity against HT29 cells (IC50value of 4.9 ± 0.4 μg/mL), weak cytotoxicity against A549, Ca Ski, and HCT116 cells (with IC50values of 46.3 ± 0.7, 32.5 ± 1.1, and 35.0 ± 0.3 μg/mL, resp.), and no inhibitory effect against MCF7 cells. It exhibited mild cytotoxicity against a noncancerous human lung fibroblast cell line (MRC5), with an IC50value of 25.2 ± 2.7 μg/mL. This is the first report on the chemical composition of this rhizome’s oil and its selective antiproliferative effect on HT29. The obtained data provided a basis for further investigation of the mode of cell death.

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