Overexpression of chromosome 14 open reading frame 166 correlates with disease progression and poorer prognosis in human NPC

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 7977-7986 ◽  
Author(s):  
Lin Yang ◽  
Fengyan Li ◽  
Fangyong Lei ◽  
Yan Wang ◽  
Shu Wu ◽  
...  
Keyword(s):  
Disease Progression ◽  
Open Reading Frame ◽  
Chromosome 14 ◽  
Reading Frame

scholarly journals Differential expression of C14orf132 in cancer of the vulva.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Disease Progression ◽  
Differential Expression ◽  
Microarray Data ◽  
Transcriptome Analysis ◽  
Vulvar Cancer ◽  
Open Reading Frame ◽  
Vulvar Carcinoma ◽  
Chromosome 14 ◽  
Reading Frame ◽  
Tissue Of Origin

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of chromosome 14 open reading frame 132, encoded by C14orf132, in cancer of the vulva. C14orf132 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

scholarly journals Longitudinal and multi-tissue molecular diagnostics track somatic BRCA2 reversion mutations that correct the open reading frame of germline alteration upon clinical relapse

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Shelly Sorrells ◽  
Kelly E. McKinnon ◽  
Ashleigh McBratney ◽  
Christopher Sumey
Keyword(s):  
Disease Progression ◽  
Parp Inhibitor ◽  
Acquired Resistance ◽  
Open Reading Frame ◽  
Genomic Testing ◽  
Clinical Relapse ◽  
Resistance Mutations ◽  
Reading Frame ◽  
Germline Alteration ◽  
Over Time

AbstractBRCA-mutant cancers often develop therapeutic resistance through several mechanisms. Here, we report a case of pathogenic germline BRCA2-driven breast cancer monitored for disease progression and acquired resistance using longitudinal multi-tissue genomic testing. Briefly, genomic testing was performed throughout the course of disease on tumor tissue from multiple sites, circulating tumor DNA from blood plasma, and matched normal tissue. Genomic analyses identified actionable variants for targeted therapies, as well as emerging resistance mutations over time. Two unique BRCA2 somatic alterations (p.N255fs and p.D252fs) were identified upon resistance to PARP inhibitor and platinum treatment, respectively. Both alterations restored the open reading frame of the original germline alteration, likely accounting for acquired resistance. This case exemplifies the evolution of multiple subclonal BRCA reversion alterations over time and demonstrates the value of longitudinal multi-tissue genomic testing for monitoring disease progression, predicting measures of response, and evaluating treatment outcomes in oncology patients.

Mapping of the bovine homologue of the human chromosome 14 open reading frame 4 (C14orf4) gene to BTA10q36

2004 ◽  
Vol 35 (6) ◽  
pp. 498-499 ◽  
Author(s):  
C. Drögemüller ◽  
H. Kuiper ◽  
A. Spötter ◽  
J. L. Williams ◽  
O. Distl
Keyword(s):  
Human Chromosome ◽  
Open Reading Frame ◽  
Chromosome 14 ◽  
Reading Frame

scholarly journals Differential expression of C1orf115 in cancer of the vulva.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Disease Progression ◽  
Differential Expression ◽  
Microarray Data ◽  
Transcriptome Analysis ◽  
Vulvar Cancer ◽  
Open Reading Frame ◽  
Chromosome 1 ◽  
Vulvar Carcinoma ◽  
Reading Frame ◽  
Tissue Of Origin

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of chromosome 1 open reading frame 115, encoded by C1orf115, in cancer of the vulva. C1orf115 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

scholarly journals Differential expression of chromosome 14 open reading frame 180 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Open Reading Frame ◽  
Differentially Expressed ◽  
Chromosome 14 ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Reading Frame

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding chromosome 14 open reading frame 180, C14orf180, when comparing primary tumors of the breast to the tissue of origin, the normal breast. C14orf180 was also differentially expressed in the brain metastases of patients with metastatic breast cancer. C14orf180 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of C14orf180 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. C14orf180 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

pDP4, a novel glycoprotein secreted by mature granulocytes, is regulated by transcription factor PU.1

Blood ◽  
2004 ◽  
Vol 103 (11) ◽  
pp. 4294-4301 ◽  
Author(s):  
Frank Rosenbauer ◽  
Katharina Wagner ◽  
Pu Zhang ◽  
Klaus-Peter Knobeloch ◽  
Atsushi Iwama ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Open Reading Frame ◽  
The Novel ◽  
Chromosome 14 ◽  
Reading Frame ◽  
Lymphoid Development ◽  
C Terminus ◽  
Extracellular Glycoprotein ◽  
Deficient Mice

Abstract The transcription factor PU.1 (Spi-1) is a well-characterized regulator of myeloid and lymphoid development. However, its role in mature functional cells is poorly studied. Here we report the characterization of the novel murine gene pDP4 (PU.1 difference product 4), which is absent from fetal livers of PU.1-deficient mice. pDP4 is transcribed as a single 3.2-kb mRNA with a 1518-base pair open reading frame encoded by 5 exons on chromosome 14. pDP4 expression is strongest in small intestine and bone marrow, in which it is expressed predominately in mature neutrophils. Interestingly, however, pDP4 expression is markedly down-regulated in neutrophils of the peripheral blood and peritoneum. The pDP4 gene encodes a secreted 57-kDa glycoprotein with an olfactomedin-like C-terminus. PU.1 binds to a functional site within the pDP4 promoter, and pDP4 expression in myeloid cells is strictly dependent on PU.1 and the presence of this site. In conclusion, we have identified a novel PU.1-regulated extracellular glycoprotein of the olfactomedin-like family with a possible role in neutrophilic trafficking. (Blood. 2004;103:4294-4301)

scholarly journals Differential expression of C6orf106 in cancer of the vulva.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Disease Progression ◽  
Differential Expression ◽  
Microarray Data ◽  
Transcriptome Analysis ◽  
Vulvar Cancer ◽  
Open Reading Frame ◽  
Chromosome 6 ◽  
Vulvar Carcinoma ◽  
Reading Frame ◽  
Tissue Of Origin

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of chromosome 6 open reading frame 106, encoded by C6orf106, in cancer of the vulva. C6orf106 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

scholarly journals Differential expression of C2orf49 in cancer of the vulva.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Disease Progression ◽  
Differential Expression ◽  
Microarray Data ◽  
Transcriptome Analysis ◽  
Vulvar Cancer ◽  
Open Reading Frame ◽  
Vulvar Carcinoma ◽  
Chromosome 2 ◽  
Reading Frame ◽  
Tissue Of Origin

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of chromosome 2 open reading frame 49, encoded by C2orf49, in cancer of the vulva. C2orf49 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).

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