MK2206 overcomes the resistance of human liver cancer stem cells to sorafenib by inhibition of pAkt and upregulation of pERK

Tumor Biology ◽  
2015 ◽  
Vol 37 (6) ◽  
pp. 8047-8055 ◽  
Author(s):  
Beibei Zhai ◽  
Xiaofeng Zhang ◽  
Bin Sun ◽  
Lu Cao ◽  
Linlin Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals miR24-2 Promotes Malignant Progression of Human Liver Cancer Stem Cells by Enhancing Tyrosine Kinase Src Epigenetically

2020 ◽  
Vol 28 (2) ◽  
pp. 572-586 ◽  
Author(s):  
Liyan Wang ◽  
Xiaonan Li ◽  
Wei Zhang ◽  
Yuxin Yang ◽  
Qiuyu Meng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Tyrosine Kinase ◽  
Human Liver ◽  
Malignant Progression ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Chen Wang ◽  
Xiaoxue Jiang ◽  
Xiaonan Li ◽  
Shuting Song ◽  
Qiuyu Meng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Noncoding Rna ◽  
Liver Cancer Stem Cells ◽  
Huh7 Cells ◽  
Human Liver Cancer

Abstract Background The functions of HULC have been demonstrated in several cancers. However, its mechanism has not been elucidated in human liver cancer stem cells. Methods Liver cancer stem cells were isolated from Huh7 cells; gene infection and tumorigenesis test in vitro and in vivo were performed. Results We demonstrate that HULC promotes growth of liver cancer stem cells in vitro and in vivo. Mechanistically, HULC enhances the expression of Sirt1 dependent on miR675 and then induces the cellular autophagy through Sirt1. HULC enhances CyclinD1 and thereby increases pRB and inhibited P21 WAF1/CIP 1 via autophagy-miR675-PKM2 pathway in human liver cancer stem cells. Ultimately, our results demonstrate that CyclinD1 is required for the oncogenic functions of HULC in liver cancer stem cells. Conclusions It reveals the key molecular signaling pathways for HULC and provides important basic information for finding effective tumor therapeutic targets based on HULC.

scholarly journals Mutant MEG3 Enhances the Activity of Telomerase by Increasing DNA Damage Repair in Human Liver Cancer Stem Cells

2021 ◽  
Author(s):  
Shuting Song ◽  
Sijie Xie ◽  
Rushi Qin ◽  
Yanan Lu ◽  
Liyan Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Dna Damage Repair ◽  
Liver Cancer Stem Cells ◽  
Damage Repair ◽  
Human Liver Cancer

Abstract Background: Long noncoding RNAs have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Although wild MEG3 acts as a suppressor in several cancers, the function of mutant MEG3 is also unclear during tumorigenesis.Methods: Lentivalus infection,RT-PCR,Western blotting and tumorigenesis test in vitro and in vivo were performed.Results: our results suggest that mutant MEG3 promotes the growth of human liver cancer stem cells in vivo and in vitro.Mechanistically, our results show that mutant MEG3 enhances acetylation modification of HistoneH4 on K16.Then, mutant MEG3 enhances the expression of SETD2 dependent on H4K16Ac.Moreover, mutant MEG3 increases the DNA damage repair through SETD2.Ultimately, mutant MEG3 increases the telomeras activity dependent on DNA damage repair.Strikingly,TERT determines the cancerous function of mutant MEG3 in liver cancer stem cells. Therefore, we shed light on the fact that targeting mutant MEG3 could be a viable approach for cancer treatment.Conclusions: these observations will play an important role in finding effective tumor treatment targets.

scholarly journals CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

2021 ◽  
Vol 23 ◽  
pp. 310-323
Author(s):  
Xiaoxue Jiang ◽  
Libo Xing ◽  
Yingjie Chen ◽  
Rushi Qin ◽  
Shuting Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Telomerase Activity ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals COL14A1 promotes self-renewal of human liver cancer stem cells through activation of ERK signaling

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ruijiao Kong ◽  
Haidong Liu ◽  
Yi Shi ◽  
Qiuhong Man ◽  
Shanrong Liu
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Erk Signaling ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals CD13 is a therapeutic target in human liver cancer stem cells

2010 ◽  
Vol 120 (9) ◽  
pp. 3326-3339 ◽  
Author(s):  
Naotsugu Haraguchi ◽  
Hideshi Ishii ◽  
Koshi Mimori ◽  
Fumiaki Tanaka ◽  
Masahisa Ohkuma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Therapeutic Target ◽  
Human Liver ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer

scholarly journals ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells

2015 ◽  
Vol 125 (10) ◽  
pp. 3795-3808 ◽  
Author(s):  
Pingping Zhu ◽  
Yanying Wang ◽  
Lei He ◽  
Guanling Huang ◽  
Ying Du ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer
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