scholarly journals A 5-Year Follow-up Study to Assess Clinical Outcomes of Patients with Diabetes Undergoing Lower Limb Angiography for Significant Peripheral Artery Disease

2015 ◽  
Vol 6 (4) ◽  
pp. 481-493 ◽  
Author(s):  
Yisu Gu ◽  
Chatchai Kokar ◽  
Catherine Gooday ◽  
Darren Morrow ◽  
Ketan Dhatariya
Keyword(s):  
Clinical Outcomes ◽  
Peripheral Artery Disease ◽  
Lower Limb ◽  
Peripheral Artery ◽  
Follow Up Study ◽  
Patients With Diabetes ◽  
Artery Disease

scholarly journals Lower Limb Amputations in Patients With Diabetes and Peripheral Artery Disease: A Time-Series Analysis of Trends (2005-2016)

2018 ◽  
Vol 68 (3) ◽  
pp. e83-e84
Author(s):  
Mohamad A. Hussain ◽  
Mohammed Al-Omran ◽  
Konrad Salata ◽  
Jack V. Tu ◽  
Atul Sivaswamy ◽  
...  
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Peripheral Artery Disease ◽  
Lower Limb ◽  
Peripheral Artery ◽  
Series Analysis ◽  
Patients With Diabetes ◽  
Artery Disease

scholarly journals 4063Long-term clinical outcomes after lower limb revascularization in dialysis patients with peripheral artery disease

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
R Ito ◽  
S Oshima ◽  
H Ishii ◽  
T Sakakibara ◽  
S Yamabe ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Peripheral Artery Disease ◽  
Lower Limb ◽  
Dialysis Patients ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Statin Therapy Reduces Future Risk of Lower-Limb Amputation in Patients With Diabetes and Peripheral Artery Disease

2017 ◽  
Vol 102 (7) ◽  
pp. 2373-2381 ◽  
Author(s):  
Chien-Yi Hsu ◽  
Yung-Tai Chen ◽  
Yu-Wen Su ◽  
Chun-Chin Chang ◽  
Po-Hsun Huang ◽  
...  
Keyword(s):  
Statin Therapy ◽  
Peripheral Artery Disease ◽  
Lower Limb ◽  
Lower Limb Amputation ◽  
Limb Amputation ◽  
Peripheral Artery ◽  
Patients With Diabetes ◽  
Future Risk ◽  
Artery Disease

scholarly journals MP525PLAQUE SCORE AS A PREDICTOR OF PERIPHERAL ARTERY DISEASE EVENTS IN JAPANESE INCIDENT HEMODIALYSIS PATIENTS: AN OBSERVATIONAL, FOLLOW UP STUDY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i515-i515
Author(s):  
Toshihide Hayashi ◽  
Nobuhiko Joki ◽  
Yuri Tanaka ◽  
Masaki Iwasaki ◽  
Shun Kubo ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Hemodialysis Patients ◽  
Peripheral Artery ◽  
Follow Up Study ◽  
Artery Disease

scholarly journals Peripheral artery disease, lower limb revascularization, and amputation in diabetes patients with and without coronary artery disease: a cohort study from the Western Denmark Heart Registry

2021 ◽  
Vol 9 (1) ◽  
pp. e001803
Author(s):  
Kevin Kris Warnakula Olesen ◽  
Christine Gyldenkerne ◽  
Troels Thim ◽  
Reimar Wernich Thomsen ◽  
Michael Maeng
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Artery Disease ◽  
Lower Limb ◽  
Lower Limb Amputation ◽  
Limb Amputation ◽  
Peripheral Artery ◽  
Patients With Diabetes ◽  
Artery Disease ◽  
Diabetes Patients

IntroductionPatients with diabetes have increased risk of lower limb revascularization and amputation due to higher risk of peripheral artery disease (PAD) and peripheral neuropathy. The additive effect of coronary artery disease (CAD) is less clear. We examined the risk of PAD, lower limb revascularization, and amputation in diabetes and non-diabetes patients with and without CAD in patients examined by coronary angiography (CAG).Research design and methodsWe included all patients undergoing CAG between 2003 and 2016 in Western Denmark. Patients with previous CAD, PAD, lower limb revascularization, or amputation were excluded. Patients were stratified by diabetes and CAD status and followed for a maximum of 10 years. Outcomes were PAD, lower limb revascularization, and amputation. We estimated 10-year cumulative incidences and adjusted HRs (aHRs) using patients neither diabetes nor CAD as reference.ResultsA total of 118 787 patients were included, of whom 41 878 (35%) had neither diabetes nor CAD, 5735 (5%) had diabetes alone, 59 427 (50%) had CAD alone, and 11 747 (10%) had both diabetes and CAD. Median follow-up was 6.9 years. Diabetes patients without CAD had higher risk of PAD (3.5%, aHR 1.73, 95% CI 1.51 to 1.97), lower limb revascularization (1.6%, aHR 1.55, 95% CI 1.16 to 2.05), and lower limb amputation (2.4%, aHR 5.51, 95% CI 4.09 to 7.43) compared with patients with neither diabetes nor CAD. CAD was associated with 2.5-fold and 1.8-fold higher risk of PAD and amputation, respectively, among patients without diabetes, and associated with 3.9-fold and 9.5-fold higher risk of PAD and lower limb amputation among patients with diabetes.ConclusionsDespite absence of obstructive CAD, patients with diabetes remained at higher risk of PAD, lower limb revascularization, and lower limb amputation. Diabetes was more strongly associated with amputation than CAD, but CAD exacerbated the risks of PAD, revascularization, and amputation in patients with diabetes.

scholarly journals Sex differences in the prevalence and clinical outcomes of subclinical peripheral artery disease in the Health, Aging, and Body Composition (Health ABC) study

Vascular ◽  
2013 ◽  
Vol 22 (2) ◽  
pp. 142-148 ◽  
Author(s):  
Jade S Hiramoto ◽  
Ronit Katz ◽  
Joachim H Ix ◽  
Christina Wassel ◽  
Nicolas Rodondi ◽  
...  
Keyword(s):  
Body Composition ◽  
Clinical Outcomes ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Peripheral Artery ◽  
Body Composition Study ◽  
Health Aging ◽  
Artery Disease ◽  
Adjusted Model

The objective of the study was to determine if there are sex-based differences in the prevalence and clinical outcomes of subclinical peripheral artery disease (PAD). We evaluated the sex-specific associations of ankle–brachial index (ABI) with clinical cardiovascular disease outcomes in 2797 participants without prevalent clinical PAD and with a baseline ABI measurement in the Health, Aging, and Body Composition study. The mean age was 74 years, 40% were black, and 52% were women. Median follow-up was 9.37 years. Women had a similar prevalence of ABI < 0.9 (12% women versus 11% men; P = 0.44), but a higher prevalence of ABI 0.9–1.0 (15% versus 10%, respectively; P < 0.001). In a fully adjusted model, ABI < 0.9 was significantly associated with higher coronary heart disease (CHD) mortality, incident clinical PAD and incident myocardial infarction in both women and men. ABI < 0.9 was significantly associated with incident stroke only in women. ABI 0.9–1.0 was significantly associated with CHD death in both women (hazard ratio 4.84, 1.53–15.31) and men (3.49, 1.39–8.72). However, ABI 0.9–1.0 was significantly associated with incident clinical PAD (3.33, 1.44–7.70) and incident stroke (2.45, 1.38–4.35) only in women. Subclinical PAD was strongly associated with adverse CV events in both women and men, but women had a higher prevalence of subclinical PAD.

scholarly journals Peripheral arterial disease: Changes in clinical outcomes and therapeutic strategies in two cohorts, from 2002 to 2008 and from 2008 to 2014. A population-based study

2018 ◽  
Vol 25 (16) ◽  
pp. 1735-1743 ◽  
Author(s):  
Marta Baviera ◽  
Vittorio Bertelè ◽  
Fausto Avanzini ◽  
Tommaso Vannini ◽  
Mauro Tettamanti ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Clinical Outcomes ◽  
Peripheral Artery Disease ◽  
Cardiovascular Prevention ◽  
Lipid Lowering ◽  
Peripheral Artery ◽  
Risk Of Death ◽  
Coronary Syndrome ◽  
Artery Disease

Background The aim of our study was to evaluate whether treatments for peripheral artery disease changed in two different cohorts identified in 2002 and 2008, and whether this had an impact on mortality and major clinical outcomes after six years of follow-up. Methods Using administrative health databases of the largest region in Northern Italy, we identified patients admitted to hospital for peripheral artery disease in 2002 and 2008. Both cohorts were followed for six years. All cause death, acute coronary syndrome, stroke and major amputations, cardiovascular prevention drugs and revascularization procedures were collected. Incidence of events was plotted using adjusted cumulative incidence function estimates. The risk, for each outcome, was compared between 2002–2008 and 2008–2014 using a multivariable Fine and Gray’s semiparametric proportional subdistribution hazards model. Results In 2002 and 2008, 2885 and 2848 patients were identified. Adjusting for age, sex, Charlson comorbidity index and severity of peripheral artery disease we observed a significant reduction (in 2008 vs. 2002) in the risk of acute coronary syndrome (28%), stroke (27%) and major amputation (17%). No change was observed in the risk of death. The percentages of patients with peripheral artery revascularizations, during the hospital stay, increased: 43.8% in 2002 vs. 49.0% in 2008, p < 0.001. From 2002 to 2008 there was a significant absolute increase in the prescription of lipid-lowering drugs (+18%), antiplatelets (+7.2%) and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (+11.8%), p < 0.001. Conclusions In six years of follow-up we observed a reduction in risk of major cardiovascular events in 2008–2014 in comparison with the 2002–2008 cohort. Increasing use of revascularization interventions and cardiovascular prevention drugs could have contributed to the better prognosis.

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