Severe 5-Fluorouracil-Associated Gastrointestinal Toxicity Unexplained by Dihydropyrimidine Dehydrogenase Deficiency and Renal Impairment: Should We Be Investigating Other Elimination Pathways to Assess the Risk of 5-Fluorouracil Toxicity?

Gastrointestinal Toxicity ◽

Fluorouracil Toxicity ◽

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

Cancer ◽

10.1002/1097-0142(19910801)68:3<499::aid-cncr2820680309>3.0.co;2-f ◽

1991 ◽

Vol 68 (3) ◽

pp. 499-501 ◽

Cited By ~ 125

Author(s):

Barry E. Harris ◽

John T. Carpenter ◽

Robert B. Diasio

Keyword(s):

Fluorouracil Toxicity ◽

A bilateral cicatricial ectropion and bilateral upper lid shortening caused by 5-fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency

Cutaneous and Ocular Toxicology ◽

10.3109/15569527.2010.532846 ◽

2010 ◽

Vol 30 (2) ◽

pp. 157-159 ◽

Cited By ~ 2

Author(s):

Ebube E. Obi ◽

Alec McDonald ◽

Ewan Kemp

Keyword(s):

Upper Lid ◽

Fluorouracil Toxicity ◽

Cicatricial Ectropion ◽

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

Journal of Clinical Investigation ◽

10.1172/jci118830 ◽

1996 ◽

Vol 98 (3) ◽

pp. 610-615 ◽

Cited By ~ 237

Author(s):

X Wei ◽

H L McLeod ◽

J McMurrough ◽

F J Gonzalez ◽

P Fernandez-Salguero

Keyword(s):

Molecular Basis ◽

Fluorouracil Toxicity ◽

Severe 5-fluorouracil toxicity possibly secondary to dihydropyrimidine dehydrogenase deficiency in a breast cancer patient with osteogenesis imperfecta

European Journal of Cancer ◽

10.1016/0959-8049(95)00573-0 ◽

1996 ◽

Vol 32 (2) ◽

pp. 369-370 ◽

Cited By ~ 6

Author(s):

P. Beuzeboc ◽

J.-Y. Pierga ◽

D. Stoppa-Lyonnet ◽

M.C. Etienne ◽

G. Milano ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patient ◽

Osteogenesis Imperfecta ◽

Breast Cancer Patient ◽

Fluorouracil Toxicity ◽

Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity

Autopsy and Case Reports ◽

10.4322/acr.2018.049 ◽

2018 ◽

Vol 8 (4) ◽

Cited By ~ 3

Author(s):

Shiraz S. Fidai ◽

Aarti E. Sharma ◽

Daniel N. Johnson ◽

Jeremy P. Segal ◽

Ricardo R. Lastra

Keyword(s):

Fluorouracil Toxicity ◽

Severe Fluorouracil Toxicity in a Patient With Dihydropyrimidine Dehydrogenase Deficiency

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/85.19.1602 ◽

1993 ◽

Vol 85 (19) ◽

pp. 1602-1603 ◽

Cited By ~ 36

Author(s):

P. HOUYAU ◽

C. GAY ◽

E. CHATELUT ◽

P. CANAL ◽

H. ROCHE ◽

...

Keyword(s):

Fluorouracil Toxicity ◽

Dihydropyrimidine Dehydrogenase Deficiency and 5-Fluorouracil Toxicity

Handbook of Therapeutic Biomarkers in Cancer ◽

10.1201/b15029-12 ◽

2013 ◽

pp. 337-351

Author(s):

Eva Gross ◽

André van Kuilenburg

Keyword(s):

Fluorouracil Toxicity ◽

High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity

Frontiers in Genetics ◽

10.3389/fgene.2012.00312 ◽

2013 ◽

Vol 3 ◽

Cited By ~ 2

Author(s):

Emma Borràs ◽

Emma Dotor ◽

Àngels Arcusa ◽

Maria J. Gamundi ◽

Imma Hernan ◽

...

Keyword(s):

High Resolution ◽

High Resolution Melting ◽

High Resolution Melting Analysis ◽

Melting Analysis ◽

The Common ◽

Fluorouracil Toxicity ◽

P-297 Upfront dihydropyrimidine dehydrogenase deficiency detection to secure 5-FU or capecitabine administration: Application to colorectal cancer patients

Annals of Oncology ◽

10.1016/j.annonc.2021.05.351 ◽

2021 ◽

Vol 32 ◽

pp. S198

Author(s):

N. Mkedder ◽

S. Ghomari-Bezzar

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Colorectal Cancer Patients ◽

Reversible Leukoencephalopathy With Stroke-Like Presentation in a Patient With 5-Dihydropyrimidine Dehydrogenase Deficiency Treated With Continuous 5-Fluorouracil Infusion

Clinical Colorectal Cancer ◽

10.1016/j.clcc.2012.01.004 ◽

2012 ◽

Vol 11 (3) ◽

pp. 215-217 ◽

Cited By ~ 5

Author(s):

Jia Li ◽

James J. Lee ◽

Edward Chu ◽

Joachim M. Baehring

Keyword(s):