The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice

2011 ◽  
Vol 52 (3) ◽  
pp. 355-361 ◽  
Author(s):  
Gordana Brozovic ◽  
Nada Orsolic ◽  
Fabijan Knezevic ◽  
Anica Horvat Knezevic ◽  
Vesna Benkovic ◽  
...  
Keyword(s):  
Comet Assay ◽  
Alkaline Comet Assay ◽  
Swiss Albino Mice ◽  
Albino Mice

DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test

2010 ◽  
Vol 51 (1) ◽  
pp. 79-86 ◽  
Author(s):  
G. Brozovic ◽  
N. Orsolic ◽  
R. Rozgaj ◽  
V. Kasuba ◽  
F. Knezevic ◽  
...  
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Micronucleus Test ◽  
Alkaline Comet Assay ◽  
Dna Damage And Repair ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals In vivo antiplasmodial properties of fractions and flavonoids of Pseudarthria hooheri Wight & Arn. (Fabaceae)

2022 ◽  
Author(s):  
Joseph Tchamgoue ◽  
Amelework N. Eyado ◽  
Boniface P. Kamdem Kamdem ◽  
Yvan Anderson T. Ngandjui Ngandjui ◽  
Jean Claude Tchouankeu ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Malaria Treatment ◽  
Antiplasmodial Activity ◽  
Swiss Albino Mice ◽  
Treatment Situation ◽  
Healthy Female ◽  
Etoac Fraction ◽  
Albino Mice ◽  
Main Components

Malaria is regarded as one of the most lethal diseases. Resistance to artemisinin and its derivatives jeopardises effective malaria treatment. Finding novel antimalarial chemicals is critical given the existing treatment situation. This work aimed to examine the antiplasmodial capabilities of <i>Pseudarthria hookeri</i> fractions and flavonoids in vivo. The fractions and compounds antiplasmodial activity were evaluated on male Swiss albino mice infected with <i>Plasmodium berghei</i>, and on healthy female Swiss albino mice, the crude extract's acute toxicity was assessed. The EtOAc fraction had significant antiplasmodial activity (32.53 percent suppression at 500 mg/kg BW) and considerably prolonged the survival period of infected mice (9.8 days) compared to control mice (7.8 days). Parasitaemia was dramatically reduced (85.01, 59.41, and 70.39 percent), and the mean survival time extended (11.33, 10.00, and 9.33 days) with 15, 20 and 35 mg/kg of quercetin (<b>1</b>), 7-O-benzyl-6-prenylpinocembrin (<b>6</b>) and 6,8-diprenyleriodictyol (<b>11</b>) (isolates of the EtOAc fraction), respectively. BW loss and PCV reduction were also averted. Moreover, at 2500 mg/kg, the crude extract of <i>P. hookeri</i> showed no acute toxicity in mice. LC-MS analysis of the EtOAc fraction enabled the identification of nine flavonoids, with <b>8</b> and <b>11</b> being the main components. The present investigation confirmed <i>P. hookeri</i>'s antiplasmodial action, substantiating its ethnomedicinal application for malaria treatment.

scholarly journals In vivo glucose-6-phosphatase inhibitory, toxicity and antidiabetic potentials of 2-picolylamine thioureas in Swiss albino mice

2020 ◽  
Vol 27 (12) ◽  
pp. 3267-3273
Author(s):  
Sumaira Naz ◽  
Muhammad Zahoor ◽  
Muhammad Naveed Umar ◽  
Fatmah S. AlQahtany ◽  
Yousif M. Elnahas ◽  
...  
Keyword(s):  
Swiss Albino Mice ◽  
Albino Mice

Boric acid enhances in vivo Ehrlich ascites carcinoma cell proliferation in Swiss albino mice

Toxicology ◽  
2001 ◽  
Vol 165 (1) ◽  
pp. 1-11 ◽  
Author(s):  
S Qureshi ◽  
O.A Al-Shabanah ◽  
M.M Al-Harbi ◽  
A.M Al-Bekairi ◽  
M Raza
Keyword(s):  
Cell Proliferation ◽  
Boric Acid ◽  
Carcinoma Cell ◽  
Ehrlich Ascites Carcinoma ◽  
Ehrlich Ascites Carcinoma Cell ◽  
Swiss Albino Mice ◽  
Ehrlich Ascites ◽  
Albino Mice

Statistical analysis of in vivo alkaline comet assay data - Comparison of median and geometric mean as centrality measures

2020 ◽  
Vol 118 ◽  
pp. 104808
Author(s):  
Timur Tug ◽  
Katja Ickstadt ◽  
Michael Kunz ◽  
Andreas Sutter ◽  
Bernd-Wolfgang Igl
Keyword(s):  
Statistical Analysis ◽  
Comet Assay ◽  
Geometric Mean ◽  
Centrality Measures ◽  
Alkaline Comet Assay ◽  
Data Comparison

scholarly journals Dinuclear ruthenium(II) Schiff base complex: a first in vivo study in Swiss albino mice

2019 ◽  
Vol 120 (01) ◽  
pp. 26-34 ◽  
Author(s):  
V. Muzika ◽  
S. Custovic ◽  
S. Alicelebic ◽  
E. Cosovic ◽  
A. Zahirovic ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Complex ◽  
In Vivo Study ◽  
Swiss Albino Mice ◽  
Base Complex ◽  
Dinuclear Ruthenium ◽  
Albino Mice
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