Small mammary analogue secretory carcinoma arising from minor salivary gland of buccal mucosa

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. MASC has a variety of histological features and different range of clinical behaviors. The histopathological diagnosis of MASC can be difficult, and the immunohistochemical profile of MASC is still being updated. The gold standard for MASC diagnosis is cytogenetics, with the majority having a translocation t(12;15)(p133;q25). Presently, there is no conclusive evidence that MASC should be treated differently than any other low-grade malignant salivary gland tumors, though high-grade transformation has been described.

Download Full-text

Difficulty in the Cytodiagnosis of Mammary Analogue Secretory Carcinoma: Survey of 109 Cytologists with a Case Originating from a Minor Salivary Gland

Acta Cytologica ◽

10.1159/000477390 ◽

2017 ◽

Vol 61 (6) ◽

pp. 469-476 ◽

Cited By ~ 7

Author(s):

Keita Kai ◽

Akimichi Minesaki ◽

Kumiko Suzuki ◽

Mikio Monji ◽

Mitsuo Nakamura ◽

...

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Benign Lesion ◽

Minor Salivary Gland ◽

Needle Aspiration ◽

Class Iii ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Old Japanese ◽

A Minor

Background: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). Case: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i.e., class II, III, and V). To investigate the potential for discrepant diagnosis of MASC on a larger scale, we distributed a survey with questions about the cytological diagnosis of the present case to cytologists at other institutions. A total of 109 cytologists completed the survey, providing varying assessments of the Papanicolaou classification: class I/II (14%), class III (53%), and class IV/V (33%). Most of the respondents (72%) could not identify a particular tumor or disease. Even the respondents who identified a particular tumor suggested widely differing diagnoses, from a benign lesion to various malignant tumors. Only 2 respondents correctly identified MASC. Conclusion: Our experience and the results of the survey suggest difficulty in the cytodiagnosis of MASC.

Download Full-text

Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

Case Reports in Pathology ◽

10.1155/2019/2074504 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Durga Paudel ◽

Michiko Nishimura ◽

Bhoj Raj Adhikari ◽

Daichi Hiraki ◽

Aya Onishi ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Buccal Mucosa ◽

Benign Lesion ◽

Minor Salivary Gland ◽

World Health ◽

Positive Staining ◽

Minor Salivary Glands ◽

Secretory Carcinoma ◽

Eosinophilic Cytoplasm

Secretory carcinoma (SC) of the salivary gland was recently added to the fourth edition of the World Health Organization classification of head and neck tumors. Some salivary tumors, including acinic cell carcinoma, have been reclassified as SC. Most of these tumors are located on the parotid gland with very few cases reported in the minor salivary glands of the buccal mucosa. Herein, we present a case of SC of buccal mucosa, which appeared clinically as a benign lesion in a 54-year-old Japanese female patient. Histopathologically, the tumor cells presented with an eosinophilic cytoplasm with microcytic structure along with eosinophilic secretory material and hemosiderin deposit. Immunohistochemical staining revealed strongly positive staining for S100, vimentin, and mammaglobin and negative staining for DOG-1. The tumor was finally diagnosed as secretory carcinoma of the buccal mucosa. We present a review of the medical literature of SC arising from minor salivary glands. We found only 15 cases of SC of buccal mucosa out of 63 cases of SC in the minor salivary glands. They showed good prognoses and only one case of SC in the buccal mucosa exhibited local recurrence and lymph node metastases.

Download Full-text

Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers

Human Pathology ◽

10.1016/j.humpath.2014.09.012 ◽

2015 ◽

Vol 46 (1) ◽

pp. 94-103 ◽

Cited By ~ 61

Author(s):

Makoto Urano ◽

Toshitaka Nagao ◽

Satoru Miyabe ◽

Kenichiro Ishibashi ◽

Kayoko Higuchi ◽

...

Keyword(s):

Salivary Gland ◽

Surrogate Markers ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma

Download Full-text

Mammary analogue secretory carcinoma: a rare salivary gland tumor

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20201703 ◽

2020 ◽

Vol 6 (5) ◽

pp. 998

Author(s):

Shashikant Anil Pol ◽

Surinder K. Singhal ◽

Nitin Gupta ◽

Himanshu Bayad

Keyword(s):

Salivary Gland ◽

Salivary Gland Tumor ◽

Needle Aspiration ◽

Good Prognosis ◽

Low Grade ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Grade Malignancy ◽

Enhanced Computed Tomography ◽

Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

Download Full-text

Minor Salivary Gland Tumors of the Lip and Buccal Mucosa

The Laryngoscope ◽

10.1288/00005537-198901000-00002 ◽

1989 ◽

Vol 99 (1) ◽

pp. 6???9 ◽

Cited By ~ 21

Author(s):

Randal S. Weber ◽

J. Mark Palmer ◽

Adel El-Naggar ◽

Marsha D. McNeese ◽

Oscar M. Guillamondegui ◽

...

Keyword(s):

Salivary Gland ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Minor Salivary Gland Tumors

Download Full-text

Polymorphous Low-Grade Adenocarcinoma of the Upper Lip With Metachronous Myoepithelioma of the Buccal Mucosa Case Report and Literature Review of Synchronous and Metachronous Minor Salivary Gland Tumors

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2013.09.063 ◽

2013 ◽

Vol 116 (6) ◽

pp. e505-e506

Author(s):

I. Koutlas ◽

P. Argyris ◽

S. Pumbuccian ◽

K. Tosios ◽

R. Gopalakrishnan

Keyword(s):

Salivary Gland ◽

Case Report ◽

Literature Review ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Low Grade ◽

Upper Lip ◽

Minor Salivary Gland Tumors

Download Full-text

Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland

The Korean Journal of Pathology ◽

10.4132/koreanjpathol.2013.47.1.36 ◽

2013 ◽

Vol 47 (1) ◽

pp. 36 ◽

Cited By ~ 53

Author(s):

Min Jung Jung ◽

Joon Seon Song ◽

Sang Yoon Kim ◽

Soon Yuhl Nam ◽

Jong-Lyel Roh ◽

...

Keyword(s):

Salivary Gland ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma

Download Full-text

Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672013 ◽

2015 ◽

Vol 03 (01) ◽

pp. 047-050

Author(s):

Gourav Ahuja ◽

Jaideep Marya ◽

Poonam Sood

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Minor Salivary Glands ◽

Diverse Range ◽

Neck Tumors

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.

Download Full-text