Mammary Analogue Secretory Carcinoma of the Palate: Case Report and Review of the Literature

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. MASC has a variety of histological features and different range of clinical behaviors. The histopathological diagnosis of MASC can be difficult, and the immunohistochemical profile of MASC is still being updated. The gold standard for MASC diagnosis is cytogenetics, with the majority having a translocation t(12;15)(p133;q25). Presently, there is no conclusive evidence that MASC should be treated differently than any other low-grade malignant salivary gland tumors, though high-grade transformation has been described.

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Mammary analogue secretory carcinoma: a rare salivary gland tumor

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20201703 ◽

2020 ◽

Vol 6 (5) ◽

pp. 998

Author(s):

Shashikant Anil Pol ◽

Surinder K. Singhal ◽

Nitin Gupta ◽

Himanshu Bayad

Keyword(s):

Salivary Gland ◽

Salivary Gland Tumor ◽

Needle Aspiration ◽

Good Prognosis ◽

Low Grade ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Grade Malignancy ◽

Enhanced Computed Tomography ◽

Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

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Difficulty in the Cytodiagnosis of Mammary Analogue Secretory Carcinoma: Survey of 109 Cytologists with a Case Originating from a Minor Salivary Gland

Acta Cytologica ◽

10.1159/000477390 ◽

2017 ◽

Vol 61 (6) ◽

pp. 469-476 ◽

Cited By ~ 7

Author(s):

Keita Kai ◽

Akimichi Minesaki ◽

Kumiko Suzuki ◽

Mikio Monji ◽

Mitsuo Nakamura ◽

...

Keyword(s):

Salivary Gland ◽

Malignant Tumors ◽

Benign Lesion ◽

Minor Salivary Gland ◽

Needle Aspiration ◽

Class Iii ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Old Japanese ◽

A Minor

Background: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). Case: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i.e., class II, III, and V). To investigate the potential for discrepant diagnosis of MASC on a larger scale, we distributed a survey with questions about the cytological diagnosis of the present case to cytologists at other institutions. A total of 109 cytologists completed the survey, providing varying assessments of the Papanicolaou classification: class I/II (14%), class III (53%), and class IV/V (33%). Most of the respondents (72%) could not identify a particular tumor or disease. Even the respondents who identified a particular tumor suggested widely differing diagnoses, from a benign lesion to various malignant tumors. Only 2 respondents correctly identified MASC. Conclusion: Our experience and the results of the survey suggest difficulty in the cytodiagnosis of MASC.

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Mammary Analogue Secretory Carcinoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2015-0075-rs ◽

2016 ◽

Vol 140 (9) ◽

pp. 997-1001 ◽

Cited By ~ 28

Author(s):

Todd M. Stevens ◽

Vishwas Parekh

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Salivary Gland Tumor ◽

Acinic Cell Carcinoma ◽

Low Grade ◽

Secretory Carcinoma ◽

Duct Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Acinic Cell ◽

Not Otherwise Specified

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor that shares the same histologic appearance and ETV6 gene (12p13) rearrangement as secretory carcinoma of the breast. Prior to its recognition, MASC cases were commonly labeled acinic cell carcinoma and adenocarcinoma, not otherwise specified. Despite distinctive histologic features, MASC may be difficult to distinguish from other salivary gland tumors, in particular zymogen-poor acinic cell carcinoma and low-grade salivary duct carcinoma. Although characteristic morphologic and immunohistochemical features form the basis of a diagnosis of MASC, the presence of an ETV6-NTRK3 gene fusion is confirmatory. Given its recent recognition the true prognostic import of MASC is not yet clearly defined.

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Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v15i1.27148 ◽

2016 ◽

Vol 15 (1) ◽

pp. 95-98

Author(s):

Afroza Khanam ◽

Gulshan Akhter ◽

Md. Abdur Rahman

Keyword(s):

Salivary Gland ◽

Retrospective Study ◽

Parotid Gland ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Salivary Gland Tumors ◽

Major Salivary Gland ◽

Gland Tumor ◽

Minor Salivary Gland Tumors ◽

Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

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Low grade polymorphous adenocarcinoma of a minor salivary gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215100104748 ◽

1988 ◽

Vol 102 (3) ◽

pp. 284-287 ◽

Cited By ~ 10

Author(s):

C. M. Scally ◽

S. T. Irwin ◽

N. Nirodi

Keyword(s):

Salivary Gland ◽

Minor Salivary Gland ◽

Low Grade ◽

Polymorphous Adenocarcinoma ◽

A Minor

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Warthin tumor of the oropharyngeal minor salivary gland

SAGE Open Medical Case Reports ◽

10.1177/2050313x18818712 ◽

2018 ◽

Vol 6 ◽

pp. 2050313X1881871 ◽

Cited By ~ 1

Author(s):

Nicole Diaz-Segarra ◽

Lauren K Young ◽

Kristin Levin ◽

William Rafferty ◽

Joshua Brody ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Minor Salivary Gland ◽

Previous History ◽

Salivary Gland Tumor ◽

Gland Tumor ◽

Warthin Tumor ◽

Diagnosis And Management ◽

History Of ◽

A Minor

Warthin tumor is the second most common benign salivary gland tumor that classically arises in the parotid gland. It can be synchronous, metachronous, multifocal, bilateral, or unilateral, which complicates diagnosis and management. Rare cases of Warthin tumor of the minor salivary gland are described, but no cases of unilateral, synchronous Warthin tumor involving the parotid and minor salivary gland have been reported. We present a case of Warthin tumor arising from a minor salivary gland in the left oropharynx of a 71-year-old male with a previous history of left parotid Warthin tumor, later determined to be synchronous.

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Histological surprise, mammary analogue secretory carcinoma of parotid gland

International Surgery Journal ◽

10.18203/2349-2902.isj20214776 ◽

2021 ◽

Vol 8 (12) ◽

pp. 3731

Author(s):

Iram T. Pasha ◽

Akhila K. ◽

Ravikumar V. ◽

Sandeep Kumar

Keyword(s):

Salivary Gland ◽

Case Report ◽

Parotid Gland ◽

Low Grade ◽

Secretory Carcinoma ◽

Carcinoma Of The Breast ◽

Mammary Analogue Secretory Carcinoma ◽

Male Preponderance ◽

Slow Growing

A recent described entity, mammary analogue secretary carcinoma (MASC) in 2010 by Skalova et al whose morphological and immunohistochemical features are similar in secretory carcinoma of the breast and salivary gland. This is a low-grade carcinoma which presents as a firm, slow-growing, circumscribed lesion with male preponderance. We present a case report of MASC.

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