Difficulty in the Cytodiagnosis of Mammary Analogue Secretory Carcinoma: Survey of 109 Cytologists with a Case Originating from a Minor Salivary Gland

Background: Mammary analogue secretory carcinoma (MASC) of the salivary gland shows morphologic similarities and shares an immunophenotype and characteristic ETV6-NTRK3 translocation with secretory carcinoma of the breast. We present a buccal case of MASC along with a survey-based debate about its cytologic diagnosis by fine-needle aspiration (FNA). Case: FNA of the buccal nodule of a 58-year-old Japanese man was initially performed by 3 cytologists who gave different assessments of the Papanicolaou classification (i.e., class II, III, and V). To investigate the potential for discrepant diagnosis of MASC on a larger scale, we distributed a survey with questions about the cytological diagnosis of the present case to cytologists at other institutions. A total of 109 cytologists completed the survey, providing varying assessments of the Papanicolaou classification: class I/II (14%), class III (53%), and class IV/V (33%). Most of the respondents (72%) could not identify a particular tumor or disease. Even the respondents who identified a particular tumor suggested widely differing diagnoses, from a benign lesion to various malignant tumors. Only 2 respondents correctly identified MASC. Conclusion: Our experience and the results of the survey suggest difficulty in the cytodiagnosis of MASC.

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Mammary Analogue Secretory Carcinoma of the Palate: Case Report and Review of the Literature

Case Reports in Dentistry ◽

10.1155/2019/7416302 ◽

2019 ◽

Vol 2019 ◽

pp. 1-6

Author(s):

Christian Boliere ◽

James Murphy ◽

Mohammed Qaisi ◽

Frances Manosca ◽

Henry Fung

Keyword(s):

Salivary Gland ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Conclusive Evidence ◽

Histopathological Diagnosis ◽

Low Grade ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

A Minor ◽

Malignant Salivary Gland Tumors

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. MASC has a variety of histological features and different range of clinical behaviors. The histopathological diagnosis of MASC can be difficult, and the immunohistochemical profile of MASC is still being updated. The gold standard for MASC diagnosis is cytogenetics, with the majority having a translocation t(12;15)(p133;q25). Presently, there is no conclusive evidence that MASC should be treated differently than any other low-grade malignant salivary gland tumors, though high-grade transformation has been described.

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Mammary analogue secretory carcinoma: a rare salivary gland tumor

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20201703 ◽

2020 ◽

Vol 6 (5) ◽

pp. 998

Author(s):

Shashikant Anil Pol ◽

Surinder K. Singhal ◽

Nitin Gupta ◽

Himanshu Bayad

Keyword(s):

Salivary Gland ◽

Salivary Gland Tumor ◽

Needle Aspiration ◽

Good Prognosis ◽

Low Grade ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma ◽

Grade Malignancy ◽

Enhanced Computed Tomography ◽

Slow Growing

Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.

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The Milan System for Reporting Salivary Gland Cytopathology: Assessment of Cytohistological Concordance and Risk of Malignancy

Acta Cytologica ◽

10.1159/000510720 ◽

2020 ◽

pp. 1-13

Author(s):

Shilpy Jha ◽

Suvradeep Mitra ◽

Suvendu Purkait ◽

Amit Kumar Adhya

Keyword(s):

Salivary Gland ◽

Predictive Value ◽

Malignant Tumors ◽

Minor Salivary Gland ◽

Treatment Protocol ◽

Needle Aspiration ◽

Histopathological Diagnosis ◽

Wide Range ◽

Risk Of Malignancy

Introduction: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was proposed by the American Society of Cytopathology and the International Academy of Cytology to bring uniformity in the reporting system and the treatment protocol. A wide range of risk of malignancy for each category has been reported by various authors by applying the system. Aim: We intend to study the cytohistological concordance and the ROM for each of the diagnostic categories of the Milan system. Materials and Methods: The study included 292 cases of fine-needle aspiration cytology (FNAC) of salivary gland lesions over a period of 3 years. The diagnosis of these cases was reclassified into the 6 categories of the Milan system. The cytohistological concordance and ROM for each category of the Milan system were calculated based on the clinical and histopathological follow-up. Results: The patients’ age ranged from 3 to 81 years with the mean of 42.65 ± 16.3 years. The cases included 189 (64.7%) parotid, 82 (28.1%) submandibular, and 21 (7.2%) cases of minor salivary gland swellings. Follow-up histopathological diagnosis for 102 cases was available. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated to be 64.28, 97.01, 90, 86.67, and 87.37%, respectively. After reclassification, the number of cases in each category was as follows: category I: 31 (10.62%), category II: 80 (27.4%), category III: 2 (0.68%), category IVA: 143 (48.97%), category IVB: 1 (0.34%), category V: 13 (4.45%), and category VI: 22 (7.53%). The calculated ROM was as follows: category I: 42.86%, category II: 26.67%, category III: 100% category IVA: 10.17%, category IVB: 0%, category V: 71.42%, category VI: 100%. Conclusion: FNAC is an excellent procedure to differentiate benign from malignant tumors, and MSRSGC is a useful system for risk assessment and deciding the further treatment protocol. Our findings also suggest that in addition to the surgical follow-up, inclusion of the clinical and radiological follow-up may be a better strategy for calculation of ROM, especially for categories I and II.

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Small mammary analogue secretory carcinoma arising from minor salivary gland of buccal mucosa

International Cancer Conference Journal ◽

10.1007/s13691-014-0172-8 ◽

2014 ◽

Vol 4 (1) ◽

pp. 61-64 ◽

Cited By ~ 1

Author(s):

Naoto Kuroda ◽

Katsushi Miyazaki ◽

Michal Michal

Keyword(s):

Salivary Gland ◽

Buccal Mucosa ◽

Minor Salivary Gland ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma

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Cytological features of mammary analogue secretory carcinoma of salivary gland: Fine-needle aspiration of seven cases

Diagnostic Cytopathology ◽

10.1002/dc.23139 ◽

2014 ◽

Vol 42 (10) ◽

pp. 846-855 ◽

Cited By ~ 34

Author(s):

Kayoko Higuchi ◽

Makoto Urano ◽

Reisuke H. Takahashi ◽

Hisashi Oshiro ◽

Jun Matsubayashi ◽

...

Keyword(s):

Salivary Gland ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Secretory Carcinoma ◽

Fine Needle ◽

Mammary Analogue Secretory Carcinoma ◽

Cytological Features

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Diagnosis and Treatment of Secretory Carcinoma of the Oral Cavity: Report of Two Cases and Pooled Analysis of the Recent Literature

10.21203/rs.3.rs-285629/v1 ◽

2021 ◽

Author(s):

Masaru Ogawa ◽

Satoshi Yokoo ◽

Takahiro Yamaguchi ◽

Keisuke Suzuki ◽

Mai Seki ◽

...

Keyword(s):

Salivary Gland ◽

Oral Cavity ◽

Fusion Gene ◽

Minor Salivary Gland ◽

Salivary Gland Tumor ◽

Cervical Lymph Node Metastasis ◽

Japanese Woman ◽

Secretory Carcinoma ◽

Tissue Samples ◽

Old Japanese

Abstract Background: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast in terms of its association with neurotrophic tyrosine receptor kinase (NTRK) fusion-positive gene. SC is a recently described salivary gland tumor, and there are few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature.Case presentation: The patients included a 65-year-old Japanese woman presented with a mass of the upper lip and an 84-year-old Japanese man presented with a mass on the buccal mucosa, respectively. Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 (ETV6-NTRK3) gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. Conclusion: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is the same as that for AciCC, but SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Making an accurate diagnosis in cooperation with pathologists and confirming the presence of the ETV6-NTRK3 fusion gene using genetic analysis is important.

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Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature

Case Reports in Pathology ◽

10.1155/2019/2074504 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Durga Paudel ◽

Michiko Nishimura ◽

Bhoj Raj Adhikari ◽

Daichi Hiraki ◽

Aya Onishi ◽

...

Keyword(s):

Salivary Gland ◽

Salivary Glands ◽

Buccal Mucosa ◽

Benign Lesion ◽

Minor Salivary Gland ◽

World Health ◽

Positive Staining ◽

Minor Salivary Glands ◽

Secretory Carcinoma ◽

Eosinophilic Cytoplasm

Secretory carcinoma (SC) of the salivary gland was recently added to the fourth edition of the World Health Organization classification of head and neck tumors. Some salivary tumors, including acinic cell carcinoma, have been reclassified as SC. Most of these tumors are located on the parotid gland with very few cases reported in the minor salivary glands of the buccal mucosa. Herein, we present a case of SC of buccal mucosa, which appeared clinically as a benign lesion in a 54-year-old Japanese female patient. Histopathologically, the tumor cells presented with an eosinophilic cytoplasm with microcytic structure along with eosinophilic secretory material and hemosiderin deposit. Immunohistochemical staining revealed strongly positive staining for S100, vimentin, and mammaglobin and negative staining for DOG-1. The tumor was finally diagnosed as secretory carcinoma of the buccal mucosa. We present a review of the medical literature of SC arising from minor salivary glands. We found only 15 cases of SC of buccal mucosa out of 63 cases of SC in the minor salivary glands. They showed good prognoses and only one case of SC in the buccal mucosa exhibited local recurrence and lymph node metastases.

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