Biological and electrochemical studies of Co2+, Ni2+, Cu2+, Zn2+ and Cd2+ metal complexes of Schiff base ligand derived from 4-amino benzoic acid and isonicotinic hydrazide

A new Schiff base, 3-ethoxy salicylidene amino benzoic acid (ETSAN), has been synthesized from 3-ethoxy salicylaldehyde and 2-amino benzoic acid. Metal complexes of the Schiff base were prepared from nitrate/chloride salts of Ni(II), Co(II) Cu(II) and Zn(II) in an alcoholic medium. The complexes were non-electrolytes in dimethyl sulfoxide solvent (DMSO). The chemical structures of the Schiff-base ligand and its metal complexes were confirmed by various spectroscopic studies like IR, UV-VIS, 1H NMR, 13C NMR, ESI-mass spectra, elemental analysis, molar conductance, thermogravimetric studies and magnetic susceptibility measurements. On the basis of elemental and spectral studies, six-coordinated geometry was assigned to these complexes. In the light of these results, it is suggested that this ligand acts as neutral and tridentate and coordinates to each metal atom by azomethine nitrogen and oxygen atoms of hydroxyl group of the 3-ethoxy salicylaldehyde, besides the hydroxyl group of the carboxyl group of 2-amino benzoic acid. The mass spectral data confirms the monomeric structure of the metal complexes while the TGA studies confirm the presence of water molecules in the complex. The free Schiff base and its complexes have been tested for their antibacterial as well as antifungal activity by using disc diffusion method and the results discussed. Keywords: Schiff base; 3-ethoxy salicylaldehyde; 2-amino benzoic acid; Metal complexes; Antibacterial activity; Antifungal activity. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i3.4899 J. Sci. Res. 2 (3), 513-524 (2010)

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Synthesis and Characterization of New Bidentate Schiff Base Ligand Type (NO) Donor Atoms Derived from Isatin and 3-Amino Benzoic Acid and Its Complexes with Co(II), Cu(II), Cd(II) and Hg(II) Ions

Ibn AL- Haitham Journal For Pure and Applied Science ◽

10.30526/30.3.1610 ◽

2017 ◽

Vol 30 (3) ◽

pp. 158

Author(s):

Heam Hadi Alkam

Keyword(s):

Schiff Base ◽

Benzoic Acid ◽

1H Nmr ◽

Schiff Base Ligand ◽

Chloride Content ◽

No Donor ◽

Imine Group ◽

Bidentate Schiff Base Ligand ◽

Ft Ir ◽

Amino Benzoic Acid

New bidentate Schiff base ligand (L) namely [(Z)-3-(2-oxoindolin-3ylildeneamino)benzoic acid] type (NO) was prepared via condensation of isatin and 3-amino benzoic acid in ethanol as a solvent in existence of drops of (glac. CH3COOH). The new ligand (L) was characterized base on elemental microanalysis, FT-IR, UV-Vis, 1H-NMR spectra along with melting point. Ligand complexes in general formula [M(L)2Cl2]. H2O, where: MII = Co, Cu, Cd, and Hg; L= C15H10 N2O3 were synthesized and identified by FT-IR, UV-Vis, 1H-NMR (for Cd complex only) spectra, atomic absorption, chloride content along with molar conductivity and magnetic susceptibility. It was found that the ligand behaves as bidentate on complexation via (N) atom of imine group and (O) atom of carbonyl group of five member ring. The electronic spectral data and µeff values (Co, Cu) of the complexes exhibited octahedral geometry around CoII, CuII, CdII, HgII metal ions. The results of antibacterial activity showed that only Hg(II) complex has high activity (35 mm) for staphylococcus aureas.

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(E)-4-[(4-Diethylamino-2-hydroxybenzylidene)amino]benzoic acid

Acta Crystallographica Section E Structure Reports Online ◽

10.1107/s160053681200997x ◽

2012 ◽

Vol 68 (4) ◽

pp. o1036-o1036 ◽

Cited By ~ 1

Author(s):

Hadi Kargar ◽

Zahra Sharafi ◽

Reza Kia ◽

Muhammad Nawaz Tahir

Keyword(s):

Hydrogen Bond ◽

Schiff Base ◽

Hydrogen Bonds ◽

Benzoic Acid ◽

Schiff Base Ligand ◽

Site Occupancy ◽

Compound C ◽

Benzene Rings ◽

Ring Motif ◽

Amino Benzoic Acid

In the title compound, C18H20N2O3, a potential bidentateN,O-donor Schiff base ligand, the benzene rings are inclined at an angle of 12.25 (19)°. The molecule has anEconformation about the C=N bond. One of the ethyl groups is disordered over two positions, with a refined site-occupancy ratio of 0.55 (1):0.45 (1). An intramolecular O—H...N hydrogen bond makes anS(6) ring motif. In the crystal, pairs of O—H...O hydrogen bonds link molecules, forming inversion dimers withR22(8) ring motifs.

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(E)-3-[(3-Ethoxy-2-hydroxybenzylidene)amino]benzoic acid

Acta Crystallographica Section E Structure Reports Online ◽

10.1107/s1600536812009968 ◽

2012 ◽

Vol 68 (4) ◽

pp. o1035-o1035

Author(s):

Hadi Kargar ◽

Zahra Sharafi ◽

Reza Kia ◽

Muhammad Nawaz Tahir

Keyword(s):

Hydrogen Bond ◽

Schiff Base ◽

Hydrogen Bonds ◽

Benzoic Acid ◽

Schiff Base Ligand ◽

Title Compound ◽

Compound C ◽

Benzene Rings ◽

Ring Motif ◽

Amino Benzoic Acid

In the title compound, C16H15NO4, a potential bidentateN,O-donor Schiff base ligand, the benzene rings are inclined to one another by 4.24 (12)°. The molecule has anEconformation about the C=N bond. An intramolecular O—H...N hydrogen bond makes anS(6) ring motif. In the crystal, pairs of O—H...O hydrogen bonds link the molecules, forming inversion dimers withR22(8) ring motifs. These dimers are further connected by C—H...O interactions, forming a sheet in (104). There is also a C—H...π interaction present involving neighbouring molecules.

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