Natalizumab may reduce cognitive changes and brain atrophy rate in relapsing-remitting multiple sclerosis: a prospective, 
non-randomized pilot study

2012 ◽  
Vol 20 (6) ◽  
pp. 986-990 ◽  
Author(s):  
E. Portaccio ◽  
M. L. Stromillo ◽  
B. Goretti ◽  
B. Hakiki ◽  
A. Giorgio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Brain Atrophy ◽  
Cognitive Changes ◽  
Atrophy Rate ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

scholarly journals Oligoclonal bands in the cerebrospinal fluid and increased brain atrophy in early stages of relapsing-remitting multiple sclerosis

2012 ◽  
Vol 70 (8) ◽  
pp. 574-577 ◽  
Author(s):  
Juan Ignacio Rojas ◽  
Liliana Patrucco ◽  
Santiago Tizio ◽  
Edgardo Cristiano
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Brain Atrophy ◽  
Disease Onset ◽  
Oligoclonal Bands ◽  
Matter Volume ◽  
Early Stages ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

OBJECTIVE: To determine if the presence of oligoclonal bands (OB) at early stages of multiple sclerosis was associated with higher brain atrophy, when compared with patients without OB. METHODS: Relapsing-remitting multiple sclerosis (RRMS) patients with less than two years of disease onset and OB detection in cerebrospinal fluid (CSF) were included. SIENAX was used for total brain volume (TBV), gray matter volume (GMV), and white matter volume (WMV). RESULTS: Forty patients were included, 29 had positive IgG-OB. No differences were found between positive and negative patients in gender, expanded disability status scale (EDSS), treatment received, and T2/T1 lesion load. TBV in positive IgG-OB patients was 1.5 mm³ x 10(6) compared with 1.64 mm³ x 10(6) in the negative ones (p=0.02). GMV was 0.51 mm³ x 10(6) in positive IgG-OB compared with 0.62 mm³ x 10(6) in negative ones (p=0.002). No differences in WMV (p=0.09) were seen. CONCLUSIONS: IgG-OB in the CSF was related to neurodegeneration magnetic resonance (MR) markers in early RRMS.

scholarly journals The effect of daclizumab on brain atrophy in relapsing-remitting multiple sclerosis

2013 ◽  
Vol 2 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Isabela T. Borges ◽  
Colin D. Shea ◽  
Joan Ohayon ◽  
Blake C. Jones ◽  
Roger D. Stone ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Improvement of Driving Skills in Persons With Relapsing-Remitting Multiple Sclerosis: A Pilot Study

2014 ◽  
Vol 95 (3) ◽  
pp. 531-537 ◽  
Author(s):  
Abiodun Emmanuel Akinwuntan ◽  
Hannes Devos ◽  
Kelly Baker ◽  
Kendra Phillips ◽  
Vibha Kumar ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Driving Skills ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis
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