Neuroprotective strategies of cerebrolysin for the treatment of infants with neonatal hypoxic–ischemic encephalopathy

2021 ◽  
Author(s):  
Brian Fiani ◽  
Daniel Chacon ◽  
Ryan Jarrah ◽  
Michaela Barthelmass ◽  
Claudia Covarrubias
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Neuroprotective Strategies ◽  
Ischemic Encephalopathy

scholarly journals Preconditioning and Postinsult Therapies for Perinatal Hypoxic–Ischemic Injury at Term

2010 ◽  
Vol 113 (1) ◽  
pp. 233-249 ◽  
Author(s):  
Robert D. Sanders ◽  
Helen J. Manning ◽  
Nicola J. Robertson ◽  
Daqing Ma ◽  
A. David Edwards ◽  
...  
Keyword(s):  
Perinatal Period ◽  
Rapid Identification ◽  
Postnatal Period ◽  
Hypoxic Ischemic Encephalopathy ◽  
Current Status ◽  
Neuroprotective Agents ◽  
Period 2 ◽  
Neuroprotective Strategies ◽  
The Brain ◽  
Ischemic Encephalopathy

Perinatal hypoxic-ischemic encephalopathy can be a devastating complication of childbirth. Herein, the authors review the pathophysiology of hypoxic-ischemic encephalopathy and the current status of neuroprotective strategies to ameliorate the injury centering on four themes: (1) monitoring in the perinatal period, (2) rapid identification of affected neonates to allow timely institution of therapy, (3) preconditioning therapy (a therapeutic that reduces the brain vulnerability) before hypoxic-ischemic encephalopathy, and (4) prompt institution of postinsult therapies to ameliorate the evolving injury. Recent clinical trials have demonstrated the significant benefit for hypothermic therapy in the postnatal period; furthermore, there is accumulating preclinical evidence that adjunctive therapies can enhance hypothermic neuroprotection. Advances in the understanding of preconditioning may lead to the administration of neuroprotective agents earlier during childbirth. Although most of these neuroprotective strategies have not yet entered clinical practice, there is a significant hope that further developments will enhance hypothermic neuroprotection.

scholarly journals Perinatal Hypoxic-Ischemic Encephalopathy

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Ming-Chi Lai ◽  
San-Nan Yang
Keyword(s):  
Therapeutic Strategy ◽  
Hypoxic Ischemic Encephalopathy ◽  
Pathophysiological Mechanism ◽  
Perinatal Hypoxia ◽  
Ongoing Research ◽  
Neuroprotective Strategies ◽  
Future Potential ◽  
Clinical Potential ◽  
Ischemic Encephalopathy

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research into pathophysiological mechanism of neuronal injury and therapeutic strategy after perinatal hypoxia is still limited. With the advent of promising therapy of hypothermia in HIE, this paper reviews the pathophysiology of HIE and the future potential neuroprotective strategies for clinical potential for hypoxia sufferers.

scholarly journals Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy

2015 ◽  
Vol 16 (9) ◽  
pp. 22368-22401 ◽  
Author(s):  
Brandon Dixon ◽  
Cesar Reis ◽  
Wing Ho ◽  
Jiping Tang ◽  
John Zhang
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Neuroprotective Strategies ◽  
Ischemic Encephalopathy

OUTCOME AT 4 YEARS OF AGE IN CHILDREN WITH NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY TREATED WITH HYPOTHERMIA

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
B Scelsa ◽  
T Pizzatti ◽  
S Parmiggiani ◽  
L Pogliani ◽  
B Valli ◽  
...  
Keyword(s):  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy
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