Synergistic Effect of Whitlockite Scaffolds Combined with Alendronate to Promote Bone Regeneration

2021 ◽  
Author(s):  
Jiwoon Jeong ◽  
Jung Hee Shim ◽  
Bum Mo Koo ◽  
Young Bin Choy ◽  
Chan Yeong Heo
Keyword(s):  
Synergistic Effect ◽  
Bone Regeneration

Controlled dual delivery of low doses of BMP-2 and VEGF in a silk fibroin–nanohydroxyapatite scaffold for vascularized bone regeneration

2017 ◽  
Vol 5 (33) ◽  
pp. 6963-6972 ◽  
Author(s):  
Qiang Wang ◽  
Yanxia Zhang ◽  
Bin Li ◽  
Liang Chen
Keyword(s):  
Synergistic Effect ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Low Doses ◽  
Dual Release ◽  
Vascularized Bone

Controlled dual release of low doses of BMP-2 and VEGF resulted in a synergistic effect on vascularized bone regeneration.

CAN COMBINATION of SIMVASTATIN and MELATONIN CREATE A SYNERGISTIC EFFECT ON BONE REGENERATION?

2021 ◽  
Author(s):  
Onur KOÇ ◽  
Hıfzı Hakan TÜZ ◽  
Mert OCAK ◽  
Burak BİLECENOĞLU ◽  
Ayşegül FIRAT ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Bone Regeneration

3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration

Biomaterials ◽  
2017 ◽  
Vol 135 ◽  
pp. 85-95 ◽  
Author(s):  
Wenjie Zhang ◽  
Chun Feng ◽  
Guangzheng Yang ◽  
Guanglong Li ◽  
Xun Ding ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Bone Regeneration ◽  
3D Printed ◽  
Vascularized Bone

Synergistic effect of strontium, bioactive glass and nano‐hydroxyapatite promotes bone regeneration of critical‐sized radial bone defects

2018 ◽  
Vol 107 (1) ◽  
pp. 50-64 ◽  
Author(s):  
Ahmad Oryan ◽  
Mohamadreza Baghaban Eslaminejad ◽  
Amir Kamali ◽  
Samaneh Hosseini ◽  
Forough Azam Sayahpour ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Radial Bone

scholarly journals Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Dongtak Lee ◽  
Maierdanjiang Wufuer ◽  
Insu Kim ◽  
Tae Hyun Choi ◽  
Byung Jun Kim ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Bone Regeneration ◽  
Bioactive Molecules ◽  
Collagen Scaffolds ◽  
Composite Scaffolds ◽  
Sequential Release ◽  
Hydroxyapatite Composite ◽  
Initial Release ◽  
Post Implantation ◽  
Dual Drug

AbstractThe clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses. In this study, we demonstrated the synergistic effect of two bioactive molecules, bone morphogenic protein-2 (BMP-2) and alendronate (ALN), by releasing them in a sequential manner. Collagen-hydroxyapatite composite scaffolds functionalized using BMP-2 are loaded with biodegradable microspheres where ALN is encapsulated. The results indicate an initial release of BMP-2 for a few days, followed by the sequential release of ALN after two weeks. The composite scaffolds significantly increase osteogenic activity owing to the synergistic effect of BMP-2 and ALN. Enhanced bone regeneration was identified at eight weeks post-implantation in the rat 8-mm critical-sized defect. Our findings suggest that the sequential delivery of BMP-2 and ALN from the scaffolds results in a synergistic effect on bone regeneration, which is unprecedented. Therefore, such a system exhibits potential for the application of cell-free tissue engineering.

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