A Comparison Among Microperimetry, Standard Automated Perimetry and Spectral Domain Optical Coherence Tomography in the Evaluation of the Macula in Glaucoma Eyes with Hemifield Defects

Objective. To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals.Methods. The sample comprised 338 individuals divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent a reliable SAP and imaging of the optic nerve head with the Cirrus OCT. Pearson correlations were calculated between threshold sensitivity values of SAP (converted to linear scale) and OCT parameters.Results. Mean age did not differ between the control and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.;P=0.15). Significant differences were found for the threshold sensitivities at each of the 52 points evaluated with SAP (P<0.001) and the peripapillary retinal nerve fiber layer (RNFL) thicknesses, except at 3 and 9 clock-hour positions between both groups. Mild to moderate correlations (ranging between 0.286 and 0.593;P<0.001) were observed between SAP and most OCT parameters in the glaucoma group. The strongest correlations were found between the inferior RNFL thickness and the superior hemifield points. The healthy group showed lower and weaker correlations than the glaucoma group.Conclusions. Peripapillary RNFL thickness measured with Cirrus OCT showed mild to moderate correlations with SAP in glaucoma patients.

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Comparing Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry to Diagnose Glaucomatous Optic Neuropathy

Journal of Glaucoma ◽

10.1097/ijg.0000000000000048 ◽

2015 ◽

Vol 24 (5) ◽

pp. e69-e74 ◽

Cited By ~ 4

Author(s):

Harsha L. Rao ◽

Ravi K. Yadav ◽

Uday K. Addepalli ◽

Viquar U. Begum ◽

Sirisha Senthil ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Neuropathy ◽

Spectral Domain ◽

Glaucomatous Optic Neuropathy ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry

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Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa

PLoS ONE ◽

10.1371/journal.pone.0148022 ◽

2016 ◽

Vol 11 (2) ◽

pp. e0148022 ◽

Cited By ~ 24

Author(s):

Travis B. Smith ◽

Maria Parker ◽

Peter N. Steinkamp ◽

Richard G. Weleber ◽

Ning Smith ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinitis Pigmentosa ◽

Structure Function ◽

Autosomal Dominant ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Autosomal Dominant Retinitis Pigmentosa

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Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1177/1352458509359782 ◽

2010 ◽

Vol 16 (4) ◽

pp. 412-426 ◽

Cited By ~ 32

Author(s):

Michal Laron ◽

Han Cheng ◽

Bin Zhang ◽

Jade S Schiffman ◽

Rosa A Tang ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Mean Deviation ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Fiber Layer ◽

Field Of Vision ◽

Multiple Sclerosis Patients ◽

Visual Evoked

Background: Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision. Objective: To compare the sensitivity of mfVEP, Humphrey visual field (HVF) and optical coherence tomography (OCT) in detecting visual abnormality in multiple sclerosis (MS) patients. Methods: mfVEP, HVF, and OCT (retinal nerve fiber layer [RNFL]) were performed in 47 MS-ON eyes (last optic neuritis [ON] attack ≥6 months prior) and 65 MS-no-ON eyes without ON history. Criteria to define an eye as abnormal were: (1) mfVEP amplitude/latency — either amplitude or latency probability plots meeting cluster criteria with 95% specificity; (2) mfVEP amplitude or latency alone (specificity: 97% and 98%, respectively); and (3) HVF and OCT, mean deviation and RNFL thickness meeting p < 0.05, respectively. Results: MfVEP (amplitude/latency) identified more abnormality in MS-ON eyes (89%) than HVF (72%), OCT (62%), mfVEP amplitude (66%) or latency (67%) alone. Eighteen percent of MS-no-ON eyes were abnormal for both mfVEP (amplitude/latency) and HVF compared with 8% with OCT. Agreement between tests ranged from 60% to 79%. mfVEP (amplitude/latency) categorized an additional 15% of MS-ON eyes as abnormal compared with HVF and OCT combined. Conclusions: mfVEP, which detects both demyelination (increased latency) and neural degeneration (reduced amplitude), revealed more abnormality than HVF or OCT in MS patients.

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