scholarly journals Relationship between Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry in Healthy and Glaucoma Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Beatriz Abadia ◽  
Antonio Ferreras ◽  
Pilar Calvo ◽  
Mirian Ara ◽  
Blanca Ferrandez ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Standard Automated Perimetry ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Cirrus Oct ◽  
The Relationship ◽  
Glaucoma Group

Objective. To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals.Methods. The sample comprised 338 individuals divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent a reliable SAP and imaging of the optic nerve head with the Cirrus OCT. Pearson correlations were calculated between threshold sensitivity values of SAP (converted to linear scale) and OCT parameters.Results. Mean age did not differ between the control and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.;P=0.15). Significant differences were found for the threshold sensitivities at each of the 52 points evaluated with SAP (P<0.001) and the peripapillary retinal nerve fiber layer (RNFL) thicknesses, except at 3 and 9 clock-hour positions between both groups. Mild to moderate correlations (ranging between 0.286 and 0.593;P<0.001) were observed between SAP and most OCT parameters in the glaucoma group. The strongest correlations were found between the inferior RNFL thickness and the superior hemifield points. The healthy group showed lower and weaker correlations than the glaucoma group.Conclusions. Peripapillary RNFL thickness measured with Cirrus OCT showed mild to moderate correlations with SAP in glaucoma patients.

Retinal Nerve Fiber Layer Imaging with Spectral-domain Optical Coherence Tomography (OCT)—A Review of the Cirrus HD-OCT

2011 ◽  
Vol 04 (01) ◽  
pp. 12 ◽  
Author(s):  
Elaine To ◽  
Dennis Lam ◽  
Christopher Kai-shun Leung ◽  
◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Spectral Domain Oct ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

High-speed, high-resolution imaging of the retinal nerve fiber layer (RNFL) with spectral-domain optical coherence tomography (OCT) has become an essential tool for evaluation of glaucoma. The Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) is a spectral-domain OCT that provides visualization of the distribution pattern and measurement of RNFL abnormalities in a 6x6mm2optic disc region. Analysis of the RNFL thickness deviation map—a color-coded map displaying areas of RNFL abnormalities—detects glaucoma with high sensitivity and specificity. Trend analysis of average and sectorial RNFL thicknesses, and event analysis of the RNFL thickness maps and the RNFL thickness profiles can be used to detect and follow diffuse and focal RNFL progression. RNFL measurement with spectral-domain OCT could provide important information for use in formulating treatment plans and evaluating disease prognosis in the management of glaucoma.

A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

2019 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Devendra Sharma ◽  
Arvind Chauhan ◽  
Avisha Mathur
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

scholarly journals Comparison of multifocal visual evoked potential, standard automated perimetry and optical coherence tomography in assessing visual pathway in multiple sclerosis patients

2010 ◽  
Vol 16 (4) ◽  
pp. 412-426 ◽  
Author(s):  
Michal Laron ◽  
Han Cheng ◽  
Bin Zhang ◽  
Jade S Schiffman ◽  
Rosa A Tang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Standard Automated Perimetry ◽  
Fiber Layer ◽  
Field Of Vision ◽  
Multiple Sclerosis Patients ◽  
Visual Evoked

Background: Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision. Objective: To compare the sensitivity of mfVEP, Humphrey visual field (HVF) and optical coherence tomography (OCT) in detecting visual abnormality in multiple sclerosis (MS) patients. Methods: mfVEP, HVF, and OCT (retinal nerve fiber layer [RNFL]) were performed in 47 MS-ON eyes (last optic neuritis [ON] attack ≥6 months prior) and 65 MS-no-ON eyes without ON history. Criteria to define an eye as abnormal were: (1) mfVEP amplitude/latency — either amplitude or latency probability plots meeting cluster criteria with 95% specificity; (2) mfVEP amplitude or latency alone (specificity: 97% and 98%, respectively); and (3) HVF and OCT, mean deviation and RNFL thickness meeting p < 0.05, respectively. Results: MfVEP (amplitude/latency) identified more abnormality in MS-ON eyes (89%) than HVF (72%), OCT (62%), mfVEP amplitude (66%) or latency (67%) alone. Eighteen percent of MS-no-ON eyes were abnormal for both mfVEP (amplitude/latency) and HVF compared with 8% with OCT. Agreement between tests ranged from 60% to 79%. mfVEP (amplitude/latency) categorized an additional 15% of MS-ON eyes as abnormal compared with HVF and OCT combined. Conclusions: mfVEP, which detects both demyelination (increased latency) and neural degeneration (reduced amplitude), revealed more abnormality than HVF or OCT in MS patients.

scholarly journals Applying a New Automated Perimetry Pattern Based on the Stimulus Distribution of the Multifocal ERG to Improve Structure-Function Investigation in Glaucoma

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Lívia M. Brandão ◽  
Matthias Monhart ◽  
Andreas Schötzau ◽  
Anna A. Ledolter ◽  
Anja M. Palmowski-Wolfe
Keyword(s):  
Optical Coherence Tomography ◽  
Structure Function ◽  
Automated Perimetry ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Retinal Structure ◽  
One Year

Purpose. To validate a new automated perimetry pattern (mf103 pattern) for the investigation of retinal structure-function relationships in glaucoma in comparison to the standard G2 pattern and to relate either field’s performance to optical coherence tomography (OCT). Methods. Automated perimetry data from the mfERG103 pattern were compared with the standard G2 pattern in glaucoma patients (18) and controls (15). The results of both (mean defect (MD) and mean sensitivity (MS)) were compared with optical coherence tomography (OCT): retinal nerve fiber layer (RNFL) thickness, macular thickness (mT), and ganglion cell analysis (GCIPL). Nine patients were followed up after one year. Results. G2 pattern and mf103 pattern did not differ significantly in MD or MS. The mf103 pattern associated significantly with more RNFL sectors in both MD and MS (p<0.01 and p<0.05, resp.). GCIPL thickness was not significantly associated with either SAP protocols. Both protocols remained comparable after one-year follow-up. Conclusions. G2 and mf103 pattern can both differentiate patients from controls with no significant difference in performance. RNFL thickness defects correlated better with mf103 than G2 with POAG. The mfERG-103 perimetry pattern can be used to establish structure-function correlations in glaucoma and may enable a more direct comparison with objective electrophysiological data.

scholarly journals Retinal thickness among normal myopic Filipinos using spectral domain optical coherence tomography

2020 ◽  
Vol 17 (2) ◽  
pp. 156-169
Author(s):  
Camille Elaine Zabala ◽  
Jubaida Mangondato-Aquino ◽  
Jose Ma. Martinez ◽  
John Mark De Leon
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Retinal Thickness ◽  
Spectral Domain ◽  
Pathologic Myopia ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Thickness Measurements ◽  
Sd Oct

Purpose: To determine mean macular and retinal nerve fiber layer (RNFL) thickness of myopic Filipinos using spectral domain optical coherence tomography (SD-OCT) and to evaluate influence of age, gender, and degree of myopia. Design: Observational clinic-based cohort. Methods: Participants were divided into two groups: low-moderate myopia [spherical equivalent (SE) -0.50 D to -6.00 D] and high-pathologic myopia (SE < -6.00 D and AL > 26.5 mm). Subgroup analyses between low myopia (refraction < -3.00 D or less) and moderate myopia (> -3.00 D to -6.00 D), and high myopia (> -6.00 D to -8.00 D) and pathologic myopia (more than -8.00 D) were done. Macular and RNFL thickness were measured by a SD-OCT and axial length (AL) with non-contact biometry. Results: Of 156 eyes, 88/156 (56%) had low-moderate myopia, 68/156 (44%) had high-pathologic myopia. There were 67/156 (43%) male and 89/156 (57%) female subjects. Mean central foveal subfield thickness measurements were 264 ± 24 μm for low myopia, 258 ± 17 μm for moderate myopia, 253 ± 25 μm for high myopia, and 218 ± 48 μm for pathologic myopia. Mean RNFL thickness measurements were 105.62 ± 3.89 μmfor low myopia, 97.6 ± 2.45 μm for moderate myopia, 85.9 ± 3.87 μm for high myopia, and 75.14 ± 3.89 μm for pathologic myopia. Average SE (p < 0.0001) decreased while AL (p < 0.0001) increased with more myopia. Myopia and age significantly affected macular and RNFL thickness parameters except for the following where only the degree of myopia was a significant factor: central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses. Conclusion: Retinal SD-OCT thickness measurements decreased with increasing level of myopia and age. Central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses may be more appropriate SD-OCT parameters among myopic Filipino patients to monitor for glaucoma since they may be less influenced by age.

COMPARISON OF RETINAL NERVE FIBER LAYER THICKNESS(RNFL) IN NORMAL AND GLAUCOMA PATIENTS WITH OPTICAL COHERENCE TOMOGRAPHY(OCT)

2021 ◽  
pp. 7-8
Author(s):  
Nirav Mehta ◽  
Nayana Dhorajiya ◽  
Rupam Desai
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Glaucoma Suspect ◽  
Rnfl Thickness ◽  
Glaucoma Group

Optical coherence tomography (OCT) has proved to be valuable in the detection of glaucomatous damage. With its high resolution and proven measurement reproducibility, OCT has the potential to become an important tool for glaucoma detection. This manuscript presents the capabilities of the OCT technology evaluate retinal nerve ber layer thickness in normal and glaucoma patients Method: -A prospective, non-randomized, observational cross-sectional study was done at Rotary eye hospital, Navsari, from September 2019 to March 2020. Groups were divided in Control and glaucoma group and further Glaucoma patients were also subdivided in to Glaucoma Suspect, OHT, NTG and POAG. Patient went under comprehensive examination and selected patient went undergone measuring average retinal nerve ber layer thickness (RNFL) was by using ZEISS CIRRUS HD OCT. Results: - In overall 120 eyes of patients, 60 eyes of control group & 60 eyes of glaucoma groups were analysed. The average RNFL measurement were signicantly thinner in glaucoma group with compared control groups were 80±14 and 89±12, (P<0.01). All four quadrant RNFL thickness were analysed in Glaucoma Suspect, OHT, NTG and POAG which was statistically highly signicant. Superior quadrant RNFL thickness among groups were 105±17, 112±16, 90±17 and 85±18 m respectively (p= < 0.01).Mean RNFL thickness showed a decrease in thickness from Non-Glaucoma to Primary Open angle glaucoma (POAG) shows statistically signicant difference. Conclusions: OCT is important instrument for measuring RNFL thickness. Study shows difference in normal and glaucoma patients and different types of glaucoma patients. OCT measurement will help in early detection of glaucoma as well as in keeping an eye on progression of glaucoma.

Comparison of the Thickness of the Fiber Layer of the Retinal Nerves in Spectral Domain Optical Coherence Tomography in Normal Eyes Older Than 40 Years

2021 ◽  
Author(s):  
Medine Gündogan ◽  
Soner Kiliç
Keyword(s):  
Optical Coherence Tomography ◽  
Random Order ◽  
Normal Subjects ◽  
Retinal Nerve Fibre Layer ◽  
Repeated Measurements ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Nerve Fibre Layer

Abstract Purpose To compare measurements of the thickness of the retinal nerve fibre layer (RNFL) and assess the agreement between three different devices for spectral domain optical coherence tomography. Material and Methods The RNFL thickness of both eyes of 23 normal subjects older than 40 years was measured using Canon HS100, Topcon Maestro, and NIDEK RS-3000 devices. Both eyes of each subject were scanned in random order. All scans were completed on the same day in the morning. The average and four quadrants (superior, inferior, nasal, and temporal) of RNFL thickness were measured. To determine the differences in RNFL thickness, analysis of variance for repeated measurements was performed. A Bland-Altman plot was plotted, and coefficients of determination were calculated. Results A total of 46 eyes of 23 subjects were enrolled in this study. The average RNFL thickness as determined by the three OCT devices was correlated (p < 0.001), but differed significantly between the three devices, as most were quadrant measurements. The mean average RNFL thickness was 98.5 ± 6.6 µm as measured by Canon HS100, 108.5 ± 8.8 µm as measured by Topcon Maestro, and 104.9 ± 9.0 µm as measured by NIDEK RS-3000. Topcon Maestro showed the highest average RNFL thickness value. Bland-Altman plots revealed considerable agreement among the three devices, except for the inferior quadrants between Topcon Maestro and NIDEK RS-3000 measurements. All three devices reveal considerable coefficients of determination values for mean RNFL thickness (0.917 – 0.127). Conclusion Although the peripapillary RNFL thickness measurements taken with Canon HS100, Topcon Maestro, and NIDEK RS-3000 were in good agreement, they were not interchangeable in clinical practice, as the values differed significantly.

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