Structure-Function Modeling of Optical Coherence Tomography and Standard Automated Perimetry in the Retina of Patients with Autosomal Dominant Retinitis Pigmentosa

Background: Multifocal visual evoked potentials (mfVEP) measure local response amplitude and latency in the field of vision. Objective: To compare the sensitivity of mfVEP, Humphrey visual field (HVF) and optical coherence tomography (OCT) in detecting visual abnormality in multiple sclerosis (MS) patients. Methods: mfVEP, HVF, and OCT (retinal nerve fiber layer [RNFL]) were performed in 47 MS-ON eyes (last optic neuritis [ON] attack ≥6 months prior) and 65 MS-no-ON eyes without ON history. Criteria to define an eye as abnormal were: (1) mfVEP amplitude/latency — either amplitude or latency probability plots meeting cluster criteria with 95% specificity; (2) mfVEP amplitude or latency alone (specificity: 97% and 98%, respectively); and (3) HVF and OCT, mean deviation and RNFL thickness meeting p < 0.05, respectively. Results: MfVEP (amplitude/latency) identified more abnormality in MS-ON eyes (89%) than HVF (72%), OCT (62%), mfVEP amplitude (66%) or latency (67%) alone. Eighteen percent of MS-no-ON eyes were abnormal for both mfVEP (amplitude/latency) and HVF compared with 8% with OCT. Agreement between tests ranged from 60% to 79%. mfVEP (amplitude/latency) categorized an additional 15% of MS-ON eyes as abnormal compared with HVF and OCT combined. Conclusions: mfVEP, which detects both demyelination (increased latency) and neural degeneration (reduced amplitude), revealed more abnormality than HVF or OCT in MS patients.

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Relationship Between Standard Automated Perimetry and Retinal Nerve Fiber Layer Parameters Obtained With Optical Coherence Tomography

Journal of Glaucoma ◽

10.1097/ijg.0b013e3181f7b121 ◽

2011 ◽

Vol 20 (7) ◽

pp. 422-432 ◽

Cited By ~ 12

Author(s):

Maria J. Lopez-Peña ◽

Antonio Ferreras ◽

Jose M. Larrosa ◽

Vicente Polo ◽

Luis E. Pablo

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Retinal Nerve Fiber

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The Structure-Function Relationship between Macular Morphology and Visual Function Analyzed by Optical Coherence Tomography in Retinitis Pigmentosa

Journal of Ophthalmology ◽

10.1155/2013/821460 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

Chang Ki Yoon ◽

Hyeong Gon Yu

Keyword(s):

Optical Coherence Tomography ◽

Retinitis Pigmentosa ◽

Structure Function ◽

Visual Function ◽

Optical Coherence ◽

Structure Function Relationship ◽

Function Relationship

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Agreement Among Spectral-Domain Optical Coherence Tomography, Standard Automated Perimetry, and Stereophotography in the Detection of Glaucoma Progression

Investigative Ophthalmology & Visual Science ◽

10.1167/iovs.14-14994 ◽

2015 ◽

Vol 56 (2) ◽

pp. 1253-1260 ◽

Cited By ~ 11

Author(s):

S. A. Banegas ◽

A. Anton ◽

A. Morilla-Grasa ◽

M. Bogado ◽

E. M. Ayala ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Spectral Domain ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Glaucoma Progression

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Applying a New Automated Perimetry Pattern Based on the Stimulus Distribution of the Multifocal ERG to Improve Structure-Function Investigation in Glaucoma

Journal of Ophthalmology ◽

10.1155/2017/8780934 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Lívia M. Brandão ◽

Matthias Monhart ◽

Andreas Schötzau ◽

Anna A. Ledolter ◽

Anja M. Palmowski-Wolfe

Keyword(s):

Optical Coherence Tomography ◽

Structure Function ◽

Automated Perimetry ◽

Optical Coherence ◽

Fiber Layer ◽

Rnfl Thickness ◽

Significant Difference ◽

Retinal Structure ◽

One Year

Purpose. To validate a new automated perimetry pattern (mf103 pattern) for the investigation of retinal structure-function relationships in glaucoma in comparison to the standard G2 pattern and to relate either field’s performance to optical coherence tomography (OCT). Methods. Automated perimetry data from the mfERG103 pattern were compared with the standard G2 pattern in glaucoma patients (18) and controls (15). The results of both (mean defect (MD) and mean sensitivity (MS)) were compared with optical coherence tomography (OCT): retinal nerve fiber layer (RNFL) thickness, macular thickness (mT), and ganglion cell analysis (GCIPL). Nine patients were followed up after one year. Results. G2 pattern and mf103 pattern did not differ significantly in MD or MS. The mf103 pattern associated significantly with more RNFL sectors in both MD and MS (p<0.01 and p<0.05, resp.). GCIPL thickness was not significantly associated with either SAP protocols. Both protocols remained comparable after one-year follow-up. Conclusions. G2 and mf103 pattern can both differentiate patients from controls with no significant difference in performance. RNFL thickness defects correlated better with mf103 than G2 with POAG. The mfERG-103 perimetry pattern can be used to establish structure-function correlations in glaucoma and may enable a more direct comparison with objective electrophysiological data.

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High Definition Optical Coherence Tomography and Standard Automated Perimetry dataset generator for glaucoma diagnosis

2009 First Annual ORNL Biomedical Science & Engineering Conference ◽

10.1109/bsec.2009.5090481 ◽

2009 ◽

Cited By ~ 1

Author(s):

Marcelo Dias ◽

Vanessa Vidotti ◽

Vital Paulino Costa ◽

Edson Satoshi Gomi

Keyword(s):

Optical Coherence Tomography ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

High Definition ◽

Glaucoma Diagnosis

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Relationship between Spectral-Domain Optical Coherence Tomography and Standard Automated Perimetry in Healthy and Glaucoma Patients

BioMed Research International ◽

10.1155/2014/514948 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Beatriz Abadia ◽

Antonio Ferreras ◽

Pilar Calvo ◽

Mirian Ara ◽

Blanca Ferrandez ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Spectral Domain ◽

Automated Perimetry ◽

Optical Coherence ◽

Standard Automated Perimetry ◽

Fiber Layer ◽

Rnfl Thickness ◽

Cirrus Oct ◽

The Relationship ◽

Glaucoma Group

Objective. To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals.Methods. The sample comprised 338 individuals divided into 2 groups according to intraocular pressure and visual field outcomes. All participants underwent a reliable SAP and imaging of the optic nerve head with the Cirrus OCT. Pearson correlations were calculated between threshold sensitivity values of SAP (converted to linear scale) and OCT parameters.Results. Mean age did not differ between the control and glaucoma groups (59.55 ± 9.7 years and 61.05 ± 9.4 years, resp.;P=0.15). Significant differences were found for the threshold sensitivities at each of the 52 points evaluated with SAP (P<0.001) and the peripapillary retinal nerve fiber layer (RNFL) thicknesses, except at 3 and 9 clock-hour positions between both groups. Mild to moderate correlations (ranging between 0.286 and 0.593;P<0.001) were observed between SAP and most OCT parameters in the glaucoma group. The strongest correlations were found between the inferior RNFL thickness and the superior hemifield points. The healthy group showed lower and weaker correlations than the glaucoma group.Conclusions. Peripapillary RNFL thickness measured with Cirrus OCT showed mild to moderate correlations with SAP in glaucoma patients.

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