Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

The Us ◽

Physiologically Based ◽

Drugs Analysis ◽

P450 Inhibitors

Usage of In Vitro Metabolism Data for Drug‐Drug Interaction in Physiologically Based Pharmacokinetic Analysis Submissions to the US Food and Drug Administration

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1819 ◽

2021 ◽

Author(s):

Jieon Lee ◽

Yuching Yang ◽

Xinyuan Zhang ◽

Jianghong Fan ◽

Manuela Grimstein ◽

...

Keyword(s):

Drug Interaction ◽

Drug Administration ◽

Food And Drug Administration ◽

In Vitro Metabolism ◽

Pharmacokinetic Analysis ◽

The Us ◽

Physiologically Based ◽

Drug Drug Interaction

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2016.1147102 ◽

2016 ◽

Vol 46 (12) ◽

pp. 1049-1055 ◽

Cited By ~ 26

Author(s):

Masahiro Utoh ◽

Hiroshi Suemizu ◽

Marina Mitsui ◽

Mirai Kawano ◽

Akiko Toda ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Human Hepatocytes ◽

Common Marmosets ◽

Evaluation of Cytochrome P450 3A4-Mediated Drug–Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacokinetics ◽

10.1007/s40262-016-0412-5 ◽

2016 ◽

Vol 55 (11) ◽

pp. 1435-1445 ◽

Cited By ~ 16

Author(s):

Nageshwar R. Budha ◽

Tao Ji ◽

Luna Musib ◽

Steve Eppler ◽

Mark Dresser ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Modeling And Simulation ◽

Interaction Potential ◽

Cytochrome P450 3A4 ◽

Physiologically Based ◽

Drug Drug Interaction

Physiologically-Based Pharmacokinetic Modeling and Simulation to Assess Potential Cytochrome P450 3A4 and Transporter-Mediated Drug−drug Interactions with Prucalopride as Victim

10.26226/morressier.57d6b2b9d462b8028d88ea6f ◽

2016 ◽

Author(s):

Aiqun Li

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Modeling And Simulation ◽

Cytochrome P450 3A4 ◽

Pharmacokinetic Modeling And Simulation

Physiologically Based ◽

Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling

Pediatric Research ◽

10.1038/s41390-019-0609-z ◽

2019 ◽

Vol 87 (3) ◽

pp. 441-449 ◽

Cited By ~ 1

Author(s):

Gaëlle Magliocco ◽

Frédérique Rodieux ◽

Jules Desmeules ◽

Caroline Flora Samer ◽

Youssef Daali

Keyword(s):

Cytochrome P450 ◽

Precision Medicine ◽

Pediatric Population ◽

Human plasma concentrations of five cytochrome P450 probes extrapolated from pharmacokinetics in dogs and minipigs using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1118650 ◽

2015 ◽

Vol 46 (9) ◽

pp. 759-764 ◽

Cited By ~ 11

Author(s):

Satomi Shida ◽

Hiroshi Yamazaki

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.585 ◽

2015 ◽

Vol 56 (3) ◽

pp. 266-283 ◽

Cited By ~ 44

Author(s):

Vijay V. Upreti ◽

Jan L. Wahlstrom

Keyword(s):

Cytochrome P450 ◽

Meta Analysis ◽

Physiologically Based ◽

Hepatic Cytochrome

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling

Xenobiotica ◽

10.3109/00498254.2015.1028511 ◽

2015 ◽

Vol 45 (10) ◽

pp. 881-886 ◽

Cited By ~ 15

Author(s):

Satomi Shida ◽

Masahiro Utoh ◽

Norie Murayama ◽

Makiko Shimizu ◽

Yasuhiro Uno ◽

...

Keyword(s):

Cytochrome P450 ◽

Human Plasma ◽

Plasma Concentrations ◽

Cynomolgus Monkeys ◽

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein–cytochrome P450 3A4 dual substrates

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12717 ◽

2021 ◽

Author(s):

Xian Pan ◽

Shinji Yamazaki ◽

Sibylle Neuhoff ◽

Mian Zhang ◽

Venkatesh Pilla Reddy

Keyword(s):

Cytochrome P450 ◽

Pleiotropic Effects ◽

Cytochrome P450 3A4 ◽

P Glycoprotein ◽

Assessment of cytochrome P450-mediated drug-drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based pharmacokinetic modeling and simulation

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1919 ◽

2014 ◽

Vol 35 (9) ◽

pp. 543-552 ◽

Cited By ~ 19

Author(s):

Chuang Lu ◽

Ajit Suri ◽

Wen Chyi Shyu ◽

Shimoga Prakash

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Renal Impairment ◽

Modeling And Simulation ◽

Interaction Potential ◽

Physiologically Based ◽

Drug Drug Interaction